ENSG00000118985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237853 ENSG00000118985 HEK293_OSMI2_2hA HEK293_TMG_2hB ELL2 protein_coding protein_coding 4.726353 1.626577 8.448921 0.1295616 0.1703413 2.369792 2.8003493 1.4266903 4.7027198 0.2245394 0.24678497 1.7138108 0.69896667 0.8726333 0.55603333 -0.31660000 1.339273e-01 1.292148e-08 FALSE TRUE
ENST00000508757 ENSG00000118985 HEK293_OSMI2_2hA HEK293_TMG_2hB ELL2 protein_coding protein_coding 4.726353 1.626577 8.448921 0.1295616 0.1703413 2.369792 0.5919905 0.0000000 1.6634943 0.0000000 0.18495906 7.3867198 0.08099167 0.0000000 0.19630000 0.19630000 1.292148e-08 1.292148e-08 FALSE TRUE
MSTRG.26647.2 ENSG00000118985 HEK293_OSMI2_2hA HEK293_TMG_2hB ELL2 protein_coding   4.726353 1.626577 8.448921 0.1295616 0.1703413 2.369792 0.3105464 0.1654776 0.1528025 0.1654776 0.09909922 -0.1081643 0.07295000 0.1030333 0.01853333 -0.08450000 1.000000e+00 1.292148e-08 FALSE TRUE
MSTRG.26647.4 ENSG00000118985 HEK293_OSMI2_2hA HEK293_TMG_2hB ELL2 protein_coding   4.726353 1.626577 8.448921 0.1295616 0.1703413 2.369792 0.3459156 0.0000000 0.7381974 0.0000000 0.43272597 6.2253470 0.04845833 0.0000000 0.08810000 0.08810000 6.553977e-02 1.292148e-08 FALSE TRUE
MSTRG.26647.5 ENSG00000118985 HEK293_OSMI2_2hA HEK293_TMG_2hB ELL2 protein_coding   4.726353 1.626577 8.448921 0.1295616 0.1703413 2.369792 0.2846727 0.0000000 0.6454010 0.0000000 0.22911759 6.0343060 0.03722083 0.0000000 0.07616667 0.07616667 3.333792e-02 1.292148e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118985 E001 272.4427987 0.0407873326 0.0081568548 0.024179941 5 95885098 95888664 3567 - 2.271 2.554 0.943
ENSG00000118985 E002 12.2616022 0.0013880064 0.1227135211 0.223829871 5 95888665 95888670 6 - 1.057 0.974 -0.306
ENSG00000118985 E003 23.3304021 0.0008800942 0.2743260452 0.413461589 5 95888671 95888807 137 - 1.253 1.442 0.658
ENSG00000118985 E004 33.9849083 0.0006797286 0.4174184675 0.560770110 5 95888808 95888987 180 - 1.416 1.574 0.543
ENSG00000118985 E005 22.6476064 0.0008485866 0.8049714740 0.875899916 5 95889086 95889130 45 - 1.260 1.383 0.429
ENSG00000118985 E006 0.4502799 0.0294113253 0.5597318630 0.687804595 5 95890949 95891102 154 - 0.162 0.000 -10.126
ENSG00000118985 E007 46.6623325 0.0005145745 0.8838713849 0.929748540 5 95891103 95891274 172 - 1.562 1.675 0.386
ENSG00000118985 E008 30.3251306 0.0008220221 0.4285062939 0.571254279 5 95895628 95895691 64 - 1.398 1.442 0.153
ENSG00000118985 E009 89.3009588 0.0003899907 0.0132731246 0.036555121 5 95898240 95898763 524 - 1.864 1.861 -0.010
ENSG00000118985 E010 15.7578344 0.0513637727 0.4570458408 0.597412381 5 95898764 95898810 47 - 1.135 1.120 -0.054
ENSG00000118985 E011 0.1515154 0.0432805536 1.0000000000   5 95900228 95900692 465 - 0.061 0.000 -8.542
ENSG00000118985 E012 19.8675976 0.0547159024 0.1695026104 0.287549125 5 95900693 95900780 88 - 1.246 1.145 -0.358
ENSG00000118985 E013 26.3537161 0.0047047701 0.0111324783 0.031483939 5 95900956 95901080 125 - 1.368 1.235 -0.464
ENSG00000118985 E014 0.1451727 0.0436284278 1.0000000000   5 95901081 95901132 52 - 0.061 0.000 -8.541
ENSG00000118985 E015 13.6990319 0.0013165662 0.0513880729 0.111620494 5 95906523 95906523 1 - 1.101 0.974 -0.463
ENSG00000118985 E016 43.0053653 0.0193302939 0.0485429056 0.106584279 5 95906524 95906782 259 - 1.567 1.479 -0.301
ENSG00000118985 E017 0.4418608 0.0252823857 0.5604544513 0.688455846 5 95913326 95913770 445 - 0.162 0.000 -10.125
ENSG00000118985 E018 22.2375375 0.0039371621 0.0569070794 0.121302438 5 95913771 95913819 49 - 1.295 1.216 -0.276
ENSG00000118985 E019 25.1781811 0.0008112742 0.0028955570 0.009957787 5 95913820 95913934 115 - 1.359 1.197 -0.570
ENSG00000118985 E020 25.4097115 0.0007849337 0.0010765463 0.004223060 5 95919424 95919545 122 - 1.368 1.177 -0.670
ENSG00000118985 E021 1.2231704 0.0117402428 0.5171901301 0.651630931 5 95932632 95932663 32 - 0.313 0.231 -0.589
ENSG00000118985 E022 2.4118855 0.0489564480 0.1156836795 0.213797463 5 95932664 95932713 50 - 0.514 0.231 -1.690
ENSG00000118985 E023 0.0000000       5 95942918 95943001 84 -      
ENSG00000118985 E024 19.7882483 0.0026398267 0.0005442957 0.002325609 5 95943002 95943049 48 - 1.274 1.005 -0.965
ENSG00000118985 E025 23.8130617 0.0008293552 0.0007963869 0.003246468 5 95961575 95961851 277 - 1.345 1.135 -0.742