ENSG00000118900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262376 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding protein_coding 28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 5.4398696 2.5785681 8.9226975 0.76602275 0.1599074 1.78694165 0.19811667 0.07656667 0.340566667 0.26400000 1.285131e-04 4.862131e-06 FALSE TRUE
ENST00000589191 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding nonsense_mediated_decay 28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 5.3363243 14.2495866 0.2093167 1.48448713 0.1530967 -6.02277252 0.16587500 0.42706667 0.008166667 -0.41890000 4.862131e-06 4.862131e-06 FALSE FALSE
ENST00000590769 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding protein_coding 28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 7.8197205 8.7030590 8.7775051 0.71694399 0.5357989 0.01227431 0.27831250 0.26096667 0.334933333 0.07396667 2.635697e-01 4.862131e-06 FALSE TRUE
MSTRG.11993.10 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding   28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 0.5394361 0.1093851 1.5175412 0.05580214 0.3742092 3.67751631 0.02039167 0.00330000 0.057466667 0.05416667 7.770580e-06 4.862131e-06 FALSE TRUE
MSTRG.11993.13 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding   28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 1.7828516 3.2967383 0.1147518 0.37955869 0.1147518 -4.72827652 0.05613333 0.09846667 0.004433333 -0.09403333 6.049867e-03 4.862131e-06 FALSE TRUE
MSTRG.11993.6 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding   28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 2.2052468 1.9223015 2.5171487 0.40796724 0.8600734 0.38719037 0.08262500 0.05723333 0.095633333 0.03840000 7.117419e-01 4.862131e-06 FALSE TRUE
MSTRG.11993.7 ENSG00000118900 HEK293_OSMI2_2hA HEK293_TMG_2hB UBN1 protein_coding   28.3142 33.41536 26.20196 0.4883525 0.4749101 -0.350718 2.6022998 0.9634641 1.4896830 0.87626853 1.0146755 0.62345780 0.10207083 0.02876667 0.057333333 0.02856667 8.267866e-01 4.862131e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118900 E001 4.088164 0.0049692556 2.349469e-04 1.112471e-03 16 4846665 4847480 816 + 0.884 0.381 -2.244
ENSG00000118900 E002 97.262774 0.0534768975 1.818761e-05 1.139188e-04 16 4847481 4848170 690 + 2.153 1.740 -1.389
ENSG00000118900 E003 32.901400 0.0028877582 2.698680e-14 8.322593e-13 16 4848171 4848210 40 + 1.701 1.251 -1.550
ENSG00000118900 E004 2.848460 0.0064114576 9.272986e-03 2.696743e-02 16 4848211 4848287 77 + 0.743 0.380 -1.695
ENSG00000118900 E005 2.770008 0.0056684795 1.468656e-01 2.574172e-01 16 4848288 4848294 7 + 0.665 0.491 -0.788
ENSG00000118900 E006 3.572055 0.0105033253 2.878713e-01 4.284149e-01 16 4848295 4848312 18 + 0.719 0.618 -0.427
ENSG00000118900 E007 2.842039 0.0905203519 9.320806e-01 9.612195e-01 16 4848313 4848317 5 + 0.571 0.614 0.193
ENSG00000118900 E008 4.781610 0.0721748806 6.056434e-02 1.275795e-01 16 4848318 4848379 62 + 0.883 0.616 -1.084
ENSG00000118900 E009 3.680798 0.0365612422 2.388836e-02 5.957608e-02 16 4848380 4848393 14 + 0.809 0.491 -1.375
ENSG00000118900 E010 1.616755 0.0082762097 5.108499e-01 6.460029e-01 16 4852215 4852878 664 + 0.449 0.381 -0.371
ENSG00000118900 E011 148.147686 0.0002353087 9.023213e-21 6.335881e-19 16 4852879 4853139 261 + 2.265 2.062 -0.681
ENSG00000118900 E012 78.422397 0.0003642925 1.320108e-07 1.310473e-06 16 4853140 4853166 27 + 1.967 1.827 -0.468
ENSG00000118900 E013 1.254401 0.0107746084 5.212895e-02 1.129489e-01 16 4854957 4855083 127 + 0.115 0.492 2.799
ENSG00000118900 E014 123.760018 0.0048754336 2.420424e-07 2.283380e-06 16 4857990 4858076 87 + 2.173 2.008 -0.554
ENSG00000118900 E015 77.259688 0.0065075364 1.864340e-08 2.186280e-07 16 4858568 4858573 6 + 2.002 1.757 -0.825
ENSG00000118900 E016 139.051345 0.0021793996 1.330727e-09 1.927681e-08 16 4858574 4858663 90 + 2.217 2.064 -0.513
ENSG00000118900 E017 1.187581 0.0520107425 4.723011e-01 6.113378e-01 16 4858878 4859024 147 + 0.400 0.310 -0.537
ENSG00000118900 E018 178.452241 0.0021123768 1.108308e-08 1.354967e-07 16 4859025 4859159 135 + 2.309 2.186 -0.410
ENSG00000118900 E019 182.336740 0.0094813533 1.000774e-03 3.961007e-03 16 4859865 4859968 104 + 2.309 2.208 -0.336
ENSG00000118900 E020 145.846665 0.0078924952 5.462742e-03 1.718960e-02 16 4860664 4860744 81 + 2.197 2.128 -0.228
ENSG00000118900 E021 203.136234 0.0025423143 4.469892e-04 1.955450e-03 16 4860745 4860953 209 + 2.329 2.283 -0.153
ENSG00000118900 E022 146.181657 0.0070231325 6.059475e-03 1.876623e-02 16 4860954 4861058 105 + 2.196 2.137 -0.195
ENSG00000118900 E023 113.129601 0.0032543402 5.732528e-04 2.433746e-03 16 4861059 4861102 44 + 2.091 2.018 -0.244
ENSG00000118900 E024 103.194107 0.0060965353 3.074544e-03 1.048576e-02 16 4868833 4868903 71 + 2.054 1.978 -0.255
ENSG00000118900 E025 141.794246 0.0011691646 1.423367e-05 9.124679e-05 16 4870212 4870341 130 + 2.187 2.115 -0.243
ENSG00000118900 E026 180.722182 0.0002406050 1.738060e-09 2.463860e-08 16 4870516 4870634 119 + 2.299 2.210 -0.296
ENSG00000118900 E027 153.817935 0.0005829354 4.520289e-05 2.574567e-04 16 4870844 4870887 44 + 2.211 2.161 -0.169
ENSG00000118900 E028 192.515611 0.0026383829 1.406096e-02 3.836292e-02 16 4870888 4870972 85 + 2.292 2.280 -0.039
ENSG00000118900 E029 193.814194 0.0122630319 4.664170e-01 6.059449e-01 16 4871155 4871301 147 + 2.270 2.309 0.130
ENSG00000118900 E030 4.659489 0.1932300111 4.887956e-01 6.263121e-01 16 4872188 4872327 140 + 0.788 0.731 -0.228
ENSG00000118900 E031 115.582707 0.0011596108 3.461665e-01 4.903282e-01 16 4872884 4872934 51 + 2.048 2.087 0.131
ENSG00000118900 E032 111.479983 0.0002865786 7.032654e-01 8.019667e-01 16 4873031 4873073 43 + 2.020 2.080 0.200
ENSG00000118900 E033 709.592384 0.0001403086 1.875992e-01 3.107269e-01 16 4874211 4875271 1061 + 2.821 2.876 0.185
ENSG00000118900 E034 221.884964 0.0002000473 1.697282e-01 2.878493e-01 16 4875272 4875434 163 + 2.288 2.394 0.354
ENSG00000118900 E035 143.450776 0.0008106129 1.181188e-01 2.172443e-01 16 4876871 4876947 77 + 2.093 2.216 0.412
ENSG00000118900 E036 154.624185 0.0002646484 5.519044e-03 1.733682e-02 16 4876948 4877022 75 + 2.107 2.260 0.513
ENSG00000118900 E037 156.290031 0.0010883576 1.852608e-03 6.766488e-03 16 4877023 4877111 89 + 2.097 2.270 0.581
ENSG00000118900 E038 106.515736 0.0071032832 2.321189e-02 5.818391e-02 16 4877385 4877474 90 + 1.919 2.113 0.652
ENSG00000118900 E039 4.154129 0.0302180208 1.471194e-01 2.577743e-01 16 4877475 4877813 339 + 0.788 0.618 -0.706
ENSG00000118900 E040 1904.084760 0.0065528470 2.957744e-16 1.200633e-14 16 4880083 4882401 2319 + 3.088 3.407 1.060