ENSG00000118816

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237654 ENSG00000118816 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNI protein_coding protein_coding 114.0851 138.1289 107.4746 3.439819 2.398147 -0.36199 95.057209 129.69289689 82.450121 3.31729325 2.119346 -0.6534422 0.82416250 0.9389333333 0.76703333 -0.1719000 2.423152e-84 2.423152e-84 FALSE TRUE
ENST00000505609 ENSG00000118816 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNI protein_coding protein_coding 114.0851 138.1289 107.4746 3.439819 2.398147 -0.36199 2.707979 0.07079219 5.598098 0.07079219 1.364746 6.1171520 0.02402917 0.0005333333 0.05163333 0.0511000 3.667298e-05 2.423152e-84 FALSE FALSE
ENST00000515468 ENSG00000118816 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNI protein_coding protein_coding 114.0851 138.1289 107.4746 3.439819 2.398147 -0.36199 15.621830 8.14456785 18.825749 0.27707968 1.194283 1.2077931 0.14492083 0.0589333333 0.17576667 0.1168333 3.477133e-14 2.423152e-84 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118816 E001 4215.0173266 4.850276e-03 1.243027e-22 1.064592e-20 4 77047155 77048114 960 - 3.379 3.715 1.115
ENSG00000118816 E002 2883.8984227 3.044709e-04 1.505079e-01 2.623729e-01 4 77048115 77048662 548 - 3.401 3.477 0.252
ENSG00000118816 E003 946.0763974 4.692993e-04 6.863332e-03 2.087059e-02 4 77055150 77055233 84 - 2.952 2.972 0.067
ENSG00000118816 E004 1025.8184481 1.233096e-04 3.735556e-06 2.738208e-05 4 77055234 77055322 89 - 2.997 3.003 0.022
ENSG00000118816 E005 842.8700210 9.661728e-05 3.977885e-09 5.278409e-08 4 77055323 77055380 58 - 2.924 2.911 -0.044
ENSG00000118816 E006 868.6221127 1.066186e-04 1.499431e-11 3.034210e-10 4 77055962 77056043 82 - 2.943 2.919 -0.079
ENSG00000118816 E007 538.3512670 1.637475e-04 2.408012e-09 3.326430e-08 4 77056044 77056064 21 - 2.742 2.707 -0.117
ENSG00000118816 E008 579.4645637 5.510070e-04 1.467507e-08 1.754479e-07 4 77056065 77056100 36 - 2.779 2.737 -0.141
ENSG00000118816 E009 444.3398065 1.337874e-03 5.252305e-08 5.637264e-07 4 77056101 77056102 2 - 2.680 2.609 -0.239
ENSG00000118816 E010 741.0789613 1.188828e-03 3.222661e-07 2.962268e-06 4 77056249 77056323 75 - 2.886 2.840 -0.153
ENSG00000118816 E011 2.4564669 9.192424e-03 3.039244e-01 4.458987e-01 4 77056324 77056485 162 - 0.600 0.476 -0.581
ENSG00000118816 E012 377.0153080 5.028604e-03 1.521919e-03 5.707896e-03 4 77058507 77058509 3 - 2.603 2.540 -0.210
ENSG00000118816 E013 620.2664440 5.035150e-03 1.501376e-03 5.640119e-03 4 77058510 77058558 49 - 2.815 2.759 -0.186
ENSG00000118816 E014 763.9174897 2.833455e-03 1.082037e-06 8.916426e-06 4 77058559 77058617 59 - 2.918 2.840 -0.259
ENSG00000118816 E015 553.6082177 9.906133e-04 7.391022e-10 1.123762e-08 4 77058618 77058635 18 - 2.774 2.704 -0.232
ENSG00000118816 E016 0.7384472 4.681419e-02 3.751778e-01 5.195865e-01 4 77064713 77065080 368 - 0.326 0.195 -0.982
ENSG00000118816 E017 0.1472490 4.376588e-02 3.317257e-01   4 77066165 77066248 84 - 0.137 0.000 -9.445
ENSG00000118816 E018 947.4615817 2.888139e-03 1.489721e-08 1.778456e-07 4 77066249 77066405 157 - 3.022 2.926 -0.320
ENSG00000118816 E019 0.8200183 1.651920e-02 3.690931e-01 5.135328e-01 4 77074790 77074910 121 - 0.326 0.196 -0.974
ENSG00000118816 E020 2.1379838 2.095919e-01 1.455357e-01 2.556023e-01 4 77075099 77075471 373 - 0.638 0.336 -1.518
ENSG00000118816 E021 771.4174954 6.369598e-03 6.840309e-04 2.840525e-03 4 77075472 77076368 897 - 2.920 2.846 -0.247