ENSG00000118762

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237596 ENSG00000118762 HEK293_OSMI2_2hA HEK293_TMG_2hB PKD2 protein_coding protein_coding 7.645816 3.520287 11.22281 0.09521144 0.3419095 1.669861 2.2924484 0.5889370 4.959352 0.08007443 0.2458335 3.05258166 0.2605583 0.16650000 0.4429667 0.27646667 1.475640e-06 1.47564e-06 FALSE TRUE
ENST00000502363 ENSG00000118762 HEK293_OSMI2_2hA HEK293_TMG_2hB PKD2 protein_coding protein_coding 7.645816 3.520287 11.22281 0.09521144 0.3419095 1.669861 2.0472859 2.1414025 2.124084 0.37382529 0.2466657 -0.01166066 0.3258208 0.60550000 0.1884667 -0.41703333 2.687696e-04 1.47564e-06 FALSE TRUE
MSTRG.25148.2 ENSG00000118762 HEK293_OSMI2_2hA HEK293_TMG_2hB PKD2 protein_coding   7.645816 3.520287 11.22281 0.09521144 0.3419095 1.669861 1.2777296 0.3817936 2.080499 0.19166425 0.1596150 2.41568177 0.1562083 0.11146667 0.1850333 0.07356667 6.424048e-01 1.47564e-06 FALSE TRUE
MSTRG.25148.4 ENSG00000118762 HEK293_OSMI2_2hA HEK293_TMG_2hB PKD2 protein_coding   7.645816 3.520287 11.22281 0.09521144 0.3419095 1.669861 0.9120624 0.1310304 1.358221 0.13103039 0.3649019 3.27822288 0.1041500 0.03823333 0.1219667 0.08373333 2.626856e-01 1.47564e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118762 E001 14.6589017 0.0012537920 8.728337e-03 2.560637e-02 4 88007635 88008073 439 + 1.141 0.909 -0.851
ENSG00000118762 E002 11.2804519 0.0123542795 4.163299e-02 9.406263e-02 4 88008074 88008198 125 + 1.035 0.826 -0.788
ENSG00000118762 E003 5.5178045 0.0351640437 3.799936e-01 5.242554e-01 4 88008199 88008209 11 + 0.749 0.659 -0.373
ENSG00000118762 E004 7.2358282 0.0534362518 2.564960e-01 3.934608e-01 4 88008210 88008231 22 + 0.860 0.721 -0.551
ENSG00000118762 E005 12.2696305 0.0023857473 5.774453e-02 1.227636e-01 4 88008232 88008328 97 + 1.064 0.909 -0.575
ENSG00000118762 E006 26.5085185 0.0008782211 6.298748e-03 1.939743e-02 4 88019458 88019571 114 + 1.377 1.221 -0.546
ENSG00000118762 E007 2.3345662 0.0073761710 4.762937e-01 6.149345e-01 4 88031085 88031140 56 + 0.468 0.384 -0.447
ENSG00000118762 E008 0.0000000       4 88036064 88036135 72 +      
ENSG00000118762 E009 0.5975289 0.0234499015 3.999865e-01 5.437095e-01 4 88036136 88036219 84 + 0.203 0.001 -8.460
ENSG00000118762 E010 39.1616873 0.0006109334 3.026887e-04 1.390448e-03 4 88036220 88036353 134 + 1.544 1.362 -0.627
ENSG00000118762 E011 49.1021268 0.0004807299 1.239766e-06 1.009368e-05 4 88038251 88038445 195 + 1.647 1.401 -0.845
ENSG00000118762 E012 30.6574804 0.0013993228 1.579484e-04 7.826239e-04 4 88038446 88038501 56 + 1.447 1.202 -0.854
ENSG00000118762 E013 22.4636233 0.0012994541 1.143172e-05 7.495866e-05 4 88043233 88043260 28 + 1.334 0.945 -1.396
ENSG00000118762 E014 48.1362417 0.0004617190 2.903284e-06 2.179413e-05 4 88043261 88043457 197 + 1.637 1.401 -0.810
ENSG00000118762 E015 41.3838810 0.0004997256 1.384040e-02 3.786369e-02 4 88046642 88046793 152 + 1.551 1.469 -0.284
ENSG00000118762 E016 29.2876746 0.0006848285 2.480824e-01 3.836673e-01 4 88046794 88046870 77 + 1.393 1.388 -0.016
ENSG00000118762 E017 37.5977360 0.0005778800 3.869042e-01 5.310706e-01 4 88051991 88052069 79 + 1.491 1.518 0.093
ENSG00000118762 E018 28.8835049 0.0021834024 3.766081e-01 5.209313e-01 4 88052070 88052109 40 + 1.385 1.400 0.052
ENSG00000118762 E019 29.5775224 0.0006728915 9.533550e-01 9.748331e-01 4 88052110 88052158 49 + 1.377 1.458 0.280
ENSG00000118762 E020 0.0000000       4 88056066 88056085 20 +      
ENSG00000118762 E021 64.2605784 0.0004302097 2.755924e-01 4.149238e-01 4 88056086 88056267 182 + 1.716 1.746 0.101
ENSG00000118762 E022 58.8271791 0.0004423971 1.003676e-01 1.910337e-01 4 88057983 88058103 121 + 1.685 1.680 -0.016
ENSG00000118762 E023 51.7304161 0.0004412120 3.491383e-01 4.933630e-01 4 88061906 88062004 99 + 1.622 1.654 0.109
ENSG00000118762 E024 72.0670292 0.0029281694 1.876315e-01 3.107568e-01 4 88065374 88065495 122 + 1.768 1.783 0.048
ENSG00000118762 E025 4.1671463 0.0995660866 6.157538e-01 7.339465e-01 4 88065496 88065761 266 + 0.648 0.586 -0.272
ENSG00000118762 E026 76.9055487 0.0003306203 1.204274e-01 2.205781e-01 4 88065762 88065879 118 + 1.795 1.808 0.042
ENSG00000118762 E027 79.7331940 0.0004565562 2.277237e-02 5.727390e-02 4 88067898 88068061 164 + 1.817 1.793 -0.079
ENSG00000118762 E028 74.9227222 0.0003925789 4.590271e-01 5.992579e-01 4 88074812 88074959 148 + 1.756 1.879 0.413
ENSG00000118762 E029 388.8749846 0.0086432711 2.798246e-13 7.470678e-12 4 88075458 88077777 2320 + 2.402 2.743 1.134