ENSG00000118600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261234 ENSG00000118600 HEK293_OSMI2_2hA HEK293_TMG_2hB RXYLT1 protein_coding protein_coding 12.88323 6.751082 20.41081 0.1045023 0.7292173 1.594714 4.8148684 2.837522 7.5893582 0.19928677 0.5675879 1.416171 0.37732083 0.4208333 0.371800000 -0.04903333 6.604642e-01 1.206425e-15 FALSE TRUE
ENST00000537373 ENSG00000118600 HEK293_OSMI2_2hA HEK293_TMG_2hB RXYLT1 protein_coding nonsense_mediated_decay 12.88323 6.751082 20.41081 0.1045023 0.7292173 1.594714 2.2005768 1.129421 2.8176145 0.09854915 0.7294857 1.311285 0.16652500 0.1669667 0.140666667 -0.02630000 7.968236e-01 1.206425e-15 FALSE TRUE
ENST00000537982 ENSG00000118600 HEK293_OSMI2_2hA HEK293_TMG_2hB RXYLT1 protein_coding nonsense_mediated_decay 12.88323 6.751082 20.41081 0.1045023 0.7292173 1.594714 1.1656813 0.000000 3.1121760 0.00000000 0.4502420 8.286408 0.07929583 0.0000000 0.151266667 0.15126667 1.206425e-15 1.206425e-15 FALSE FALSE
ENST00000543342 ENSG00000118600 HEK293_OSMI2_2hA HEK293_TMG_2hB RXYLT1 protein_coding nonsense_mediated_decay 12.88323 6.751082 20.41081 0.1045023 0.7292173 1.594714 0.9806715 1.079896 0.1416589 0.07333643 0.1416589 -2.845289 0.08731250 0.1601000 0.006566667 -0.15353333 4.762136e-03 1.206425e-15 FALSE TRUE
ENST00000690060 ENSG00000118600 HEK293_OSMI2_2hA HEK293_TMG_2hB RXYLT1 protein_coding nonsense_mediated_decay 12.88323 6.751082 20.41081 0.1045023 0.7292173 1.594714 2.5604545 1.307769 4.8948946 0.05166685 0.3048910 1.896125 0.20227083 0.1935667 0.239966667 0.04640000 3.492531e-01 1.206425e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118600 E001 1.8529515 0.0440302687 0.3591699672 0.503501327 12 63779833 63779841 9 + 0.478 0.313 -0.928
ENSG00000118600 E002 2.4701740 0.0062308436 0.3519384544 0.496154102 12 63779842 63779848 7 + 0.557 0.412 -0.722
ENSG00000118600 E003 6.5417023 0.0025453556 0.3990932011 0.542830135 12 63779849 63779865 17 + 0.882 0.797 -0.330
ENSG00000118600 E004 7.9603954 0.0021111343 0.2019811255 0.328683866 12 63779866 63779869 4 + 0.965 0.833 -0.505
ENSG00000118600 E005 33.1615752 0.0008767353 0.2401796426 0.374341919 12 63779870 63779908 39 + 1.518 1.470 -0.165
ENSG00000118600 E006 79.3688962 0.0061194598 0.1971769269 0.322698215 12 63779909 63780111 203 + 1.886 1.841 -0.153
ENSG00000118600 E007 30.0633955 0.0064272826 0.0953753457 0.183457778 12 63780112 63780113 2 + 1.490 1.385 -0.363
ENSG00000118600 E008 30.5323012 0.0041756669 0.0174354169 0.045901715 12 63780114 63780116 3 + 1.509 1.355 -0.532
ENSG00000118600 E009 35.7205239 0.0011144731 0.0052918009 0.016725880 12 63780117 63780125 9 + 1.577 1.420 -0.537
ENSG00000118600 E010 32.4365596 0.0008695915 0.0137364012 0.037622091 12 63780126 63780129 4 + 1.533 1.393 -0.481
ENSG00000118600 E011 4.5653360 0.0036869552 0.4887356111 0.626260579 12 63780130 63780160 31 + 0.750 0.671 -0.323
ENSG00000118600 E012 30.9805389 0.0019772350 0.0003881148 0.001728912 12 63780161 63780462 302 + 1.536 1.301 -0.812
ENSG00000118600 E013 5.0648294 0.0035902482 0.1683117943 0.286002785 12 63780463 63781018 556 + 0.683 0.895 0.845
ENSG00000118600 E014 128.4603629 0.0064992646 0.0500561012 0.109268525 12 63781019 63781174 156 + 2.100 2.033 -0.224
ENSG00000118600 E015 14.3454511 0.0128482234 0.7190111449 0.813969791 12 63782541 63782704 164 + 1.135 1.198 0.227
ENSG00000118600 E016 120.5658795 0.0003265701 0.0584674907 0.124007688 12 63784970 63785072 103 + 2.064 2.029 -0.115
ENSG00000118600 E017 9.3825756 0.0018482217 0.0053659887 0.016924788 12 63785073 63786802 1730 + 0.859 1.183 1.194
ENSG00000118600 E018 1.7360052 0.0080575600 0.9001005823 0.940258027 12 63786803 63787059 257 + 0.416 0.412 -0.021
ENSG00000118600 E019 0.5922303 0.0179867719 0.8753553477 0.923955854 12 63789814 63789887 74 + 0.205 0.184 -0.193
ENSG00000118600 E020 9.1434291 0.0018764396 0.8151941951 0.882956152 12 63789888 63789931 44 + 0.975 0.975 0.002
ENSG00000118600 E021 3.1144544 0.0882090139 0.0167475772 0.044381970 12 63790319 63790553 235 + 0.699 0.184 -2.922
ENSG00000118600 E022 216.8654652 0.0034973135 0.7505098871 0.837176357 12 63802091 63802405 315 + 2.294 2.335 0.136
ENSG00000118600 E023 1.6105155 0.1644518710 0.1945480652 0.319438956 12 63803705 63804950 1246 + 0.477 0.183 -1.936
ENSG00000118600 E024 0.1472490 0.0426342973 1.0000000000   12 63804951 63805233 283 + 0.079 0.000 -7.498
ENSG00000118600 E025 163.1373591 0.0035684015 0.0259613208 0.063868976 12 63805234 63805404 171 + 2.145 2.260 0.381
ENSG00000118600 E026 3.9545555 0.0040962084 0.9139324374 0.949497170 12 63805405 63808674 3270 + 0.664 0.671 0.031
ENSG00000118600 E027 247.4607065 0.0079620448 0.0002176242 0.001039307 12 63808675 63809792 1118 + 2.298 2.481 0.612