ENSG00000118564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412094 ENSG00000118564 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL5 protein_coding protein_coding 34.97581 53.78952 28.8487 0.4485902 0.511547 -0.8985871 3.9933838 1.147249565 6.091510 0.480375439 1.3315068 2.398466 0.13840000 0.0211666667 0.21253333 0.19136667 1.346820e-04 1.113784e-23 FALSE TRUE
ENST00000507700 ENSG00000118564 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL5 protein_coding retained_intron 34.97581 53.78952 28.8487 0.4485902 0.511547 -0.8985871 1.5423823 0.008007908 2.695951 0.008007908 0.4219936 7.231361 0.05546250 0.0001333333 0.09376667 0.09363333 1.113784e-23 1.113784e-23 FALSE TRUE
ENST00000511441 ENSG00000118564 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL5 protein_coding nonsense_mediated_decay 34.97581 53.78952 28.8487 0.4485902 0.511547 -0.8985871 0.7712759 0.017990560 2.077044 0.017990560 0.4347542 6.220377 0.02752917 0.0003333333 0.07186667 0.07153333 2.776843e-15 1.113784e-23 FALSE TRUE
MSTRG.24650.14 ENSG00000118564 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL5 protein_coding   34.97581 53.78952 28.8487 0.4485902 0.511547 -0.8985871 17.5624999 34.690075371 8.814475 2.249877464 0.8824578 -1.975356 0.46740417 0.6444666667 0.30666667 -0.33780000 7.746297e-06 1.113784e-23   FALSE
MSTRG.24650.16 ENSG00000118564 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL5 protein_coding   34.97581 53.78952 28.8487 0.4485902 0.511547 -0.8985871 7.7486086 15.268197517 3.334924 1.307154373 0.7371320 -2.191429 0.20516250 0.2842666667 0.11510000 -0.16916667 5.984182e-03 1.113784e-23   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118564 E001 11.3792620 0.0375616773 5.989172e-01 7.204233e-01 4 15604381 15605005 625 - 1.158 1.043 -0.415
ENSG00000118564 E002 202.4580857 0.0355299031 3.985332e-06 2.900646e-05 4 15605006 15605799 794 - 2.526 2.061 -1.554
ENSG00000118564 E003 5.7340569 0.0420273437 2.321621e-09 3.217440e-08 4 15612013 15612265 253 - 1.190 0.106 -5.713
ENSG00000118564 E004 63.7136609 0.0004094579 2.775440e-28 4.029110e-26 4 15612266 15612414 149 - 2.065 1.501 -1.905
ENSG00000118564 E005 195.9252259 0.0071310996 9.995566e-43 4.054882e-40 4 15625252 15625977 726 - 2.590 1.867 -2.417
ENSG00000118564 E006 29.0440785 0.0008760002 1.604667e-23 1.506439e-21 4 15626873 15626955 83 - 1.783 1.029 -2.622
ENSG00000118564 E007 48.7457773 0.0010019251 6.744464e-43 2.777649e-40 4 15627885 15628033 149 - 2.020 1.179 -2.875
ENSG00000118564 E008 62.5023527 0.0004177230 2.956515e-62 3.237589e-59 4 15630666 15630791 126 - 2.135 1.239 -3.050
ENSG00000118564 E009 0.2966881 0.0290785164 1.620879e-01   4 15636373 15636493 121 - 0.247 0.000 -12.387
ENSG00000118564 E010 58.6461799 0.0045811312 1.203953e-38 3.826935e-36 4 15636494 15636589 96 - 2.102 1.244 -2.922
ENSG00000118564 E011 51.4899788 0.0027483303 4.076881e-35 1.003056e-32 4 15636590 15636670 81 - 2.032 1.245 -2.686
ENSG00000118564 E012 28.3725059 0.0012050353 2.517663e-24 2.579577e-22 4 15636671 15636676 6 - 1.780 0.994 -2.742
ENSG00000118564 E013 36.6624088 0.0014619057 1.146355e-29 1.873801e-27 4 15638508 15638538 31 - 1.889 1.101 -2.718
ENSG00000118564 E014 30.8465925 0.0006482572 2.640554e-25 2.961782e-23 4 15638539 15638548 10 - 1.809 1.051 -2.631
ENSG00000118564 E015 56.3080992 0.0106975677 2.311280e-22 1.915420e-20 4 15638549 15638689 141 - 2.066 1.300 -2.607
ENSG00000118564 E016 24.3628846 0.0331510478 3.200843e-09 4.320556e-08 4 15638690 15638694 5 - 1.710 0.941 -2.703
ENSG00000118564 E017 38.1442530 0.0081139898 2.747321e-19 1.617879e-17 4 15640788 15640840 53 - 1.893 1.154 -2.541
ENSG00000118564 E018 29.4620877 0.0023684713 1.309802e-21 1.000960e-19 4 15640841 15640848 8 - 1.785 1.040 -2.591
ENSG00000118564 E019 33.7639128 0.0005894656 1.322586e-28 1.966719e-26 4 15640849 15640883 35 - 1.851 1.072 -2.696
ENSG00000118564 E020 1.4885237 0.0191459397 4.001293e-03 1.314551e-02 4 15641524 15641627 104 - 0.648 0.106 -3.637
ENSG00000118564 E021 44.8828609 0.0004837985 3.597353e-42 1.428737e-39 4 15644493 15644657 165 - 1.985 1.138 -2.908
ENSG00000118564 E022 30.7104112 0.0006324131 1.608736e-36 4.385184e-34 4 15644658 15644708 51 - 1.842 0.868 -3.425
ENSG00000118564 E023 27.1335457 0.0007081762 6.981814e-33 1.445556e-30 4 15655204 15655382 179 - 1.791 0.816 -3.456
ENSG00000118564 E024 1.1739533 0.0120172232 9.012049e-04 3.617940e-03 4 15656229 15656342 114 - 0.608 0.000 -14.631
ENSG00000118564 E025 1.3254687 0.0100436109 3.932733e-04 1.749054e-03 4 15659727 15659730 4 - 0.647 0.000 -14.836
ENSG00000118564 E026 1.0330470 0.0118374751 2.008838e-03 7.253758e-03 4 15659731 15659740 10 - 0.565 0.000 -14.454
ENSG00000118564 E027 5.0326444 0.0033743884 6.104585e-08 6.464118e-07 4 15659741 15659922 182 - 1.096 0.263 -3.786
ENSG00000118564 E028 53.3275362 0.0004745211 1.082495e-27 1.493630e-25 4 15667631 15667632 2 - 1.304 1.860 1.902
ENSG00000118564 E029 67.8029670 0.0015032042 6.336814e-32 1.216302e-29 4 15667633 15667640 8 - 1.393 1.962 1.935
ENSG00000118564 E030 259.2604366 0.0002372258 7.043662e-122 3.812573e-118 4 15667641 15667781 141 - 1.997 2.537 1.806
ENSG00000118564 E031 316.4721095 0.0006547825 2.911154e-123 1.671241e-119 4 15667782 15667915 134 - 2.091 2.621 1.769
ENSG00000118564 E032 263.0047604 0.0002522456 8.804197e-120 4.507916e-116 4 15667916 15668040 125 - 2.012 2.542 1.772
ENSG00000118564 E033 2.6141121 0.0918259314 2.107559e-01 3.394524e-01 4 15668499 15668561 63 - 0.716 0.422 -1.354
ENSG00000118564 E034 3.3621348 0.0348355443 5.886002e-01 7.117960e-01 4 15672608 15672676 69 - 0.717 0.575 -0.608
ENSG00000118564 E035 132.8031067 0.0005916856 4.722864e-54 3.743650e-51 4 15681280 15681352 73 - 1.737 2.241 1.694
ENSG00000118564 E036 152.9803719 0.0021742895 3.723379e-49 2.137524e-46 4 15681353 15681382 30 - 1.780 2.304 1.758
ENSG00000118564 E037 243.6793810 0.0032733486 7.191748e-54 5.583832e-51 4 15681383 15681679 297 - 1.993 2.504 1.705