ENSG00000118518

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356799 ENSG00000118518 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF146 protein_coding protein_coding 15.17458 9.582945 21.70584 0.924979 0.786791 1.178702 5.4225809 3.9821357 8.2117119 0.4999785 0.6492833 1.0422781 0.3580417 0.4149000 0.37710000 -0.03780000 6.856435e-01 6.763882e-12 FALSE  
ENST00000368314 ENSG00000118518 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF146 protein_coding protein_coding 15.17458 9.582945 21.70584 0.924979 0.786791 1.178702 1.2531098 1.2058546 0.4041007 0.6276462 0.4041007 -1.5539172 0.0853500 0.1202333 0.02000000 -0.10023333 4.152938e-01 6.763882e-12 FALSE  
ENST00000476956 ENSG00000118518 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF146 protein_coding processed_transcript 15.17458 9.582945 21.70584 0.924979 0.786791 1.178702 1.9256525 0.7869296 2.4836415 0.1382172 0.4684689 1.6457299 0.1233125 0.0833000 0.11600000 0.03270000 6.629051e-01 6.763882e-12 FALSE  
ENST00000608340 ENSG00000118518 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF146 protein_coding processed_transcript 15.17458 9.582945 21.70584 0.924979 0.786791 1.178702 0.5069768 0.0000000 1.8001224 0.0000000 0.2727748 7.4999435 0.0286125 0.0000000 0.08306667 0.08306667 6.763882e-12 6.763882e-12    
ENST00000608991 ENSG00000118518 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF146 protein_coding protein_coding 15.17458 9.582945 21.70584 0.924979 0.786791 1.178702 1.1686137 0.7110509 1.7406056 0.4172732 0.3093660 1.2796811 0.0690750 0.0673000 0.07976667 0.01246667 8.060869e-01 6.763882e-12 FALSE  
ENST00000610153 ENSG00000118518 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF146 protein_coding protein_coding 15.17458 9.582945 21.70584 0.924979 0.786791 1.178702 2.5297475 2.2635670 3.1995747 0.5662772 0.5485214 0.4974246 0.1961292 0.2474333 0.14593333 -0.10150000 5.389101e-01 6.763882e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118518 E001 0.5870335 0.1517932904 1.706002e-01 2.889454e-01 6 127266726 127266829 104 + 0.287 0.000 -10.916
ENSG00000118518 E002 0.7363589 0.0156964034 7.738888e-02 1.552835e-01 6 127266830 127266839 10 + 0.336 0.000 -13.035
ENSG00000118518 E003 0.8815316 0.0135290283 4.629678e-02 1.025715e-01 6 127266840 127266848 9 + 0.381 0.000 -13.314
ENSG00000118518 E004 1.0308569 0.0224306351 2.944835e-02 7.087110e-02 6 127266849 127266850 2 + 0.421 0.000 -13.397
ENSG00000118518 E005 3.0322153 0.0052453366 4.516705e-02 1.004999e-01 6 127266851 127266863 13 + 0.697 0.372 -1.551
ENSG00000118518 E006 4.2144859 0.0164647059 5.267435e-02 1.139142e-01 6 127266864 127266871 8 + 0.805 0.513 -1.253
ENSG00000118518 E007 10.6207829 0.0016494435 8.942988e-04 3.593946e-03 6 127266872 127266882 11 + 1.163 0.808 -1.322
ENSG00000118518 E008 13.7270952 0.0015967586 8.381207e-05 4.460723e-04 6 127266883 127266887 5 + 1.274 0.891 -1.390
ENSG00000118518 E009 37.0965429 0.0074907270 4.585061e-04 2.000567e-03 6 127266888 127266925 38 + 1.649 1.405 -0.835
ENSG00000118518 E010 37.0495740 0.0007644763 4.365321e-03 1.416333e-02 6 127266926 127267044 119 + 1.623 1.470 -0.522
ENSG00000118518 E011 26.8073504 0.0370610860 5.255587e-01 6.589074e-01 6 127267045 127267095 51 + 1.453 1.388 -0.226
ENSG00000118518 E012 66.5631421 0.0004456575 3.735919e-01 5.180111e-01 6 127280231 127280340 110 + 1.829 1.811 -0.059
ENSG00000118518 E013 2.1943148 0.1798186199 6.858688e-03 2.085781e-02 6 127280341 127280515 175 + 0.652 0.000 -13.772
ENSG00000118518 E014 2.0618276 0.0071833737 1.030831e-03 4.064687e-03 6 127280516 127280604 89 + 0.631 0.000 -14.518
ENSG00000118518 E015 1.0373134 0.0118669506 2.814369e-02 6.829670e-02 6 127280605 127280748 144 + 0.421 0.000 -13.547
ENSG00000118518 E016 11.6599061 0.0015446988 5.398325e-04 2.309196e-03 6 127282287 127282395 109 + 1.197 0.838 -1.325
ENSG00000118518 E017 16.3383898 0.0082631535 8.349109e-05 4.445139e-04 6 127285208 127285348 141 + 1.344 0.960 -1.374
ENSG00000118518 E018 76.2136309 0.0003612097 1.539162e-01 2.669966e-01 6 127286050 127286177 128 + 1.892 1.855 -0.125
ENSG00000118518 E019 5.5876991 0.0973701428 3.599698e-01 5.042830e-01 6 127286178 127286351 174 + 0.866 0.702 -0.654
ENSG00000118518 E020 691.4044679 0.0011287810 5.636234e-17 2.498871e-15 6 127286616 127288567 1952 + 2.792 2.886 0.312