ENSG00000118513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367812 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding nonsense_mediated_decay 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.03218457 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.07007083 0.00000000 0.0000000 0.00000000   0.0006136245 TRUE TRUE
ENST00000367814 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding protein_coding 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.24423164 0.00000000 0.44533286 0.00000000 0.14508542 5.508850 0.29288750 0.00000000 0.5877333 0.58773333 0.0006136245 0.0006136245 FALSE TRUE
ENST00000420123 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding protein_coding 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.01279569 0.00000000 0.03780375 0.00000000 0.03780375 2.257124 0.01219583 0.00000000 0.0514000 0.05140000 0.8231775427 0.0006136245 FALSE TRUE
ENST00000430686 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding protein_coding 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.04485208 0.06277881 0.00000000 0.03174439 0.00000000 -2.863518 0.03936667 0.11096667 0.0000000 -0.11096667 0.1488020523 0.0006136245 FALSE TRUE
ENST00000442647 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding protein_coding 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.09081471 0.00000000 0.18414807 0.00000000 0.12406610 4.279085 0.11178333 0.00000000 0.2950333 0.29503333 0.3844869926 0.0006136245 FALSE TRUE
ENST00000525940 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding nonsense_mediated_decay 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.07939981 0.11984813 0.00000000 0.11984813 0.00000000 -3.698753 0.09876667 0.24890000 0.0000000 -0.24890000 0.7840825849 0.0006136245 TRUE TRUE
ENST00000526889 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding nonsense_mediated_decay 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.02852808 0.12887242 0.00000000 0.12887242 0.00000000 -3.795688 0.03140833 0.19440000 0.0000000 -0.19440000 0.7388169048 0.0006136245 TRUE TRUE
ENST00000528774 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding protein_coding 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.05146741 0.05798054 0.00000000 0.05798054 0.00000000 -2.765122 0.03948750 0.08746667 0.0000000 -0.08746667 0.6796951194 0.0006136245 FALSE TRUE
ENST00000533624 ENSG00000118513 HEK293_OSMI2_2hA HEK293_TMG_2hB MYB protein_coding protein_coding 0.8134989 0.5575232 0.7214304 0.05439275 0.08051863 0.3660412 0.03658513 0.15045924 0.00000000 0.15045924 0.00000000 -4.004135 0.07097917 0.28490000 0.0000000 -0.28490000 0.7745024673 0.0006136245 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118513 E001 0.3030308 0.507039524 5.307412e-01   6 135181308 135181314 7 + 0.182 0.000 -10.809
ENSG00000118513 E002 0.3030308 0.507039524 5.307412e-01   6 135181315 135181327 13 + 0.182 0.000 -12.823
ENSG00000118513 E003 0.4545463 0.837107948 5.244616e-01 6.579804e-01 6 135181328 135181380 53 + 0.252 0.000 -13.138
ENSG00000118513 E004 1.0436561 0.049345326 2.590959e-02 6.375991e-02 6 135181381 135181420 40 + 0.450 0.000 -14.518
ENSG00000118513 E005 1.3403442 0.079630072 1.270430e-02 3.521790e-02 6 135181421 135181507 87 + 0.523 0.000 -14.721
ENSG00000118513 E006 0.5954526 0.019387492 1.133293e-01 2.103716e-01 6 135181508 135181513 6 + 0.309 0.000 -14.000
ENSG00000118513 E007 0.5954526 0.019387492 1.133293e-01 2.103716e-01 6 135181514 135181536 23 + 0.309 0.000 -14.000
ENSG00000118513 E008 0.0000000       6 135185877 135185902 26 +      
ENSG00000118513 E009 2.2875392 0.006556086 6.329804e-03 1.948145e-02 6 135185903 135186017 115 + 0.665 0.149 -3.150
ENSG00000118513 E010 1.5469139 0.009031443 5.415965e-02 1.165290e-01 6 135186018 135186020 3 + 0.523 0.149 -2.512
ENSG00000118513 E011 2.0014602 0.007622839 1.496436e-02 4.040524e-02 6 135187834 135187905 72 + 0.614 0.149 -2.927
ENSG00000118513 E012 4.6846577 0.004059470 2.899035e-01 4.306645e-01 6 135189791 135189883 93 + 0.809 0.631 -0.734
ENSG00000118513 E013 7.7878695 0.002410563 9.199506e-01 9.534385e-01 6 135190127 135190347 221 + 0.943 0.922 -0.079
ENSG00000118513 E014 7.0493206 0.002539719 4.882282e-01 6.258221e-01 6 135192324 135192558 235 + 0.874 0.922 0.184
ENSG00000118513 E015 5.2556934 0.004138943 9.257983e-01 9.572799e-01 6 135193838 135193918 81 + 0.791 0.772 -0.078
ENSG00000118513 E016 4.8181016 0.005897865 4.415722e-01 5.832185e-01 6 135194356 135194451 96 + 0.809 0.670 -0.563
ENSG00000118513 E017 1.5351720 0.418506183 5.133483e-01 6.481764e-01 6 135194452 135194460 9 + 0.486 0.261 -1.324
ENSG00000118513 E018 0.8793520 0.275595882 3.478686e-01 4.920863e-01 6 135194461 135194686 226 + 0.181 0.353 1.274
ENSG00000118513 E019 0.0000000       6 135194960 135195081 122 +      
ENSG00000118513 E020 5.6252083 0.047892781 3.773609e-01 5.216905e-01 6 135195748 135195917 170 + 0.888 0.707 -0.718
ENSG00000118513 E021 3.4677188 0.005350700 5.558422e-02 1.189780e-01 6 135195918 135195954 37 + 0.753 0.421 -1.512
ENSG00000118513 E022 3.6599306 0.004751431 5.169314e-01 6.514365e-01 6 135195955 135196002 48 + 0.712 0.587 -0.535
ENSG00000118513 E023 0.0000000       6 135196726 135196908 183 +      
ENSG00000118513 E024 0.0000000       6 135196909 135196960 52 +      
ENSG00000118513 E025 0.6955713 0.017812146 5.907945e-01 7.136296e-01 6 135196961 135197323 363 + 0.181 0.260 0.659
ENSG00000118513 E026 5.0187207 0.003407532 7.709483e-01 8.521389e-01 6 135198908 135199050 143 + 0.809 0.740 -0.277
ENSG00000118513 E027 0.0000000       6 135199526 135199581 56 +      
ENSG00000118513 E028 5.4959647 0.003151114 2.170248e-01 3.468064e-01 6 135200085 135200199 115 + 0.753 0.877 0.487
ENSG00000118513 E029 3.9093867 0.004462234 3.650669e-01 5.094008e-01 6 135200290 135200415 126 + 0.640 0.740 0.416
ENSG00000118513 E030 0.0000000       6 135200416 135200557 142 +      
ENSG00000118513 E031 0.0000000       6 135200558 135200674 117 +      
ENSG00000118513 E032 4.1256496 0.004286677 8.594393e-01 9.133236e-01 6 135201639 135201749 111 + 0.711 0.706 -0.021
ENSG00000118513 E033 0.1482932 0.042037141 2.882520e-01   6 135202414 135202669 256 + 0.000 0.148 11.962
ENSG00000118513 E034 0.0000000       6 135202670 135202673 4 +      
ENSG00000118513 E035 0.0000000       6 135202948 135202949 2 +      
ENSG00000118513 E036 4.3063985 0.004301317 4.317167e-01 5.742492e-01 6 135203217 135203324 108 + 0.773 0.630 -0.590
ENSG00000118513 E037 0.0000000       6 135203325 135203715 391 +      
ENSG00000118513 E038 0.0000000       6 135203716 135203950 235 +      
ENSG00000118513 E039 21.5123027 0.001876809 1.278532e-08 1.545422e-07 6 135217864 135219173 1310 + 1.168 1.511 1.195