ENSG00000118507

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000431975 ENSG00000118507 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP7 protein_coding protein_coding 3.534539 2.284436 5.899603 0.04792877 0.301132 1.364922 0.4650343 0.2320890 0.8104759 0.1167466 0.1061619 1.7609236 0.1242250 0.1037333 0.1375000 0.03376667 7.924681e-01 4.169521e-08 FALSE TRUE
ENST00000537868 ENSG00000118507 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP7 protein_coding protein_coding 3.534539 2.284436 5.899603 0.04792877 0.301132 1.364922 0.2400432 0.2572075 0.0000000 0.2572075 0.0000000 -4.7398884 0.1012583 0.1163000 0.0000000 -0.11630000 6.609106e-01 4.169521e-08 FALSE FALSE
ENST00000541650 ENSG00000118507 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP7 protein_coding protein_coding 3.534539 2.284436 5.899603 0.04792877 0.301132 1.364922 1.9200027 1.6752575 2.8149230 0.3156482 0.5044782 0.7452425 0.5493083 0.7287000 0.4765667 -0.25213333 2.839907e-01 4.169521e-08 FALSE TRUE
ENST00000683794 ENSG00000118507 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP7 protein_coding protein_coding 3.534539 2.284436 5.899603 0.04792877 0.301132 1.364922 0.6780822 0.0000000 2.0546960 0.0000000 0.4950519 7.6897856 0.1639417 0.0000000 0.3484333 0.34843333 4.169521e-08 4.169521e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118507 E001 8.6683671 0.0021287057 6.576444e-04 2.743400e-03 6 131135467 131135736 270 + 1.054 0.571 -1.922
ENSG00000118507 E002 7.7731180 0.0045837459 9.562981e-03 2.769134e-02 6 131135737 131135782 46 + 0.998 0.630 -1.455
ENSG00000118507 E003 0.2903454 0.3438394557 7.924092e-01   6 131137378 131137751 374 + 0.142 0.000 -9.565
ENSG00000118507 E004 5.5263518 0.0037715243 2.003561e-02 5.156341e-02 6 131145285 131145287 3 + 0.870 0.502 -1.561
ENSG00000118507 E005 23.2370440 0.0008990263 1.500377e-01 2.617280e-01 6 131145288 131145416 129 + 1.380 1.265 -0.399
ENSG00000118507 E006 28.0377176 0.0008021709 9.747563e-02 1.866299e-01 6 131160059 131160174 116 + 1.457 1.336 -0.418
ENSG00000118507 E007 16.7226591 0.0011898773 5.900575e-01 7.129940e-01 6 131160175 131160198 24 + 1.229 1.180 -0.174
ENSG00000118507 E008 0.1472490 0.0450853251 1.000000e+00   6 131164336 131164532 197 + 0.077 0.000 -9.376
ENSG00000118507 E009 20.3397310 0.0009481811 2.408624e-01 3.751873e-01 6 131165081 131165149 69 + 1.323 1.225 -0.345
ENSG00000118507 E010 18.6780748 0.0012983653 1.927719e-01 3.172502e-01 6 131165150 131165217 68 + 1.294 1.180 -0.402
ENSG00000118507 E011 36.9498375 0.0005902676 8.996940e-02 1.750896e-01 6 131169113 131169273 161 + 1.573 1.467 -0.363
ENSG00000118507 E012 0.0000000       6 131184373 131184558 186 +      
ENSG00000118507 E013 30.6933855 0.0006800050 2.527732e-02 6.244410e-02 6 131199461 131199573 113 + 1.504 1.347 -0.543
ENSG00000118507 E014 0.0000000       6 131199991 131200062 72 +      
ENSG00000118507 E015 0.0000000       6 131200827 131200910 84 +      
ENSG00000118507 E016 32.2811593 0.0008688762 2.859966e-01 4.263599e-01 6 131219661 131219808 148 + 1.460 1.527 0.231
ENSG00000118507 E017 0.0000000       6 131250159 131250429 271 +      
ENSG00000118507 E018 0.0000000       6 131250430 131250616 187 +      
ENSG00000118507 E019 0.0000000       6 131253037 131253105 69 +      
ENSG00000118507 E020 15.7211339 0.0015136557 2.940628e-01 4.351509e-01 6 131281530 131282398 869 + 1.159 1.252 0.329
ENSG00000118507 E021 116.1972110 0.0002869770 2.077918e-11 4.105708e-10 6 131282399 131283535 1137 + 1.967 2.155 0.632