ENSG00000118503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237289 ENSG00000118503 HEK293_OSMI2_2hA HEK293_TMG_2hB TNFAIP3 protein_coding protein_coding 1.467371 1.23819 1.839667 0.1369162 0.3283077 0.5674271 0.6592096 0.6593332 0.4550239 0.03313114 0.23787603 -0.5254198 0.47841667 0.54293333 0.2803333 -0.26260000 0.566440764 0.002835682 FALSE TRUE
ENST00000420009 ENSG00000118503 HEK293_OSMI2_2hA HEK293_TMG_2hB TNFAIP3 protein_coding protein_coding 1.467371 1.23819 1.839667 0.1369162 0.3283077 0.5674271 0.1297172 0.1031601 0.5121465 0.10316007 0.27110131 2.2060897 0.06838750 0.09543333 0.2368667 0.14143333 0.615663615 0.002835682 FALSE FALSE
ENST00000421450 ENSG00000118503 HEK293_OSMI2_2hA HEK293_TMG_2hB TNFAIP3 protein_coding protein_coding 1.467371 1.23819 1.839667 0.1369162 0.3283077 0.5674271 0.3358281 0.3724183 0.1305365 0.12718367 0.13053648 -1.4442071 0.21811250 0.28716667 0.0595000 -0.22766667 0.154570727 0.002835682   FALSE
ENST00000485192 ENSG00000118503 HEK293_OSMI2_2hA HEK293_TMG_2hB TNFAIP3 protein_coding processed_transcript 1.467371 1.23819 1.839667 0.1369162 0.3283077 0.5674271 0.1448717 0.1032788 0.1505605 0.06739774 0.01933481 0.5032390 0.09791667 0.07446667 0.0871000 0.01263333 0.937018374 0.002835682 FALSE FALSE
ENST00000612899 ENSG00000118503 HEK293_OSMI2_2hA HEK293_TMG_2hB TNFAIP3 protein_coding protein_coding 1.467371 1.23819 1.839667 0.1369162 0.3283077 0.5674271 0.1977445 0.0000000 0.5913992 0.00000000 0.26511077 5.9102509 0.13715417 0.00000000 0.3361333 0.33613333 0.002835682 0.002835682 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118503 E001 1.4695060 0.0098566501 7.519508e-01 8.382950e-01 6 137867214 137867258 45 + 0.362 0.420 0.322
ENSG00000118503 E002 2.0867285 0.0679211124 9.740252e-01 9.877869e-01 6 137867259 137867321 63 + 0.489 0.483 -0.028
ENSG00000118503 E003 4.4339921 0.0037482166 4.391459e-01 5.809171e-01 6 137867322 137867443 122 + 0.774 0.668 -0.435
ENSG00000118503 E004 2.5120162 0.0060094064 5.097717e-01 6.450527e-01 6 137867444 137867494 51 + 0.587 0.482 -0.495
ENSG00000118503 E005 0.8168978 0.0149605709 3.650616e-01 5.094008e-01 6 137867495 137867518 24 + 0.310 0.148 -1.356
ENSG00000118503 E006 0.2987644 0.0290785164 3.518212e-01   6 137867519 137867542 24 + 0.182 0.000 -8.930
ENSG00000118503 E007 0.0000000       6 137867582 137867736 155 +      
ENSG00000118503 E008 5.5988453 0.0037465354 3.410781e-01 4.849866e-01 6 137871213 137871304 92 + 0.860 0.738 -0.482
ENSG00000118503 E009 10.4496941 0.0024614941 4.005882e-02 9.113863e-02 6 137871305 137871522 218 + 1.130 0.920 -0.772
ENSG00000118503 E010 11.3446067 0.0016162941 3.569601e-04 1.607173e-03 6 137874845 137875035 191 + 1.214 0.851 -1.333
ENSG00000118503 E011 6.6462012 0.0026608923 1.173921e-01 2.162290e-01 6 137875688 137875835 148 + 0.958 0.769 -0.727
ENSG00000118503 E012 1.2825162 0.0191718552 5.467944e-01 6.768968e-01 6 137875838 137875995 158 + 0.310 0.419 0.643
ENSG00000118503 E013 6.4462984 0.0199182364 1.740789e-01 2.934808e-01 6 137875996 137876166 171 + 0.945 0.768 -0.684
ENSG00000118503 E014 7.0556935 0.0023931957 2.543511e-01 3.910190e-01 6 137877076 137877256 181 + 0.958 0.826 -0.504
ENSG00000118503 E015 4.8486947 0.0201222966 7.839737e-01 8.614235e-01 6 137878432 137878525 94 + 0.755 0.796 0.165
ENSG00000118503 E016 22.5825226 0.0010850574 9.522623e-02 1.832119e-01 6 137878526 137879351 826 + 1.415 1.303 -0.388
ENSG00000118503 E017 8.7104100 0.0427889097 9.210171e-02 1.783962e-01 6 137880071 137880252 182 + 0.877 1.092 0.798
ENSG00000118503 E018 55.9139859 0.0007289177 1.287108e-08 1.554895e-07 6 137881035 137883312 2278 + 1.646 1.863 0.735