ENSG00000118482

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262043 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 1.4613129 0.18285035 3.1190116 0.18285035 0.15844462 4.0201533 0.13528750 0.11870000 0.17473333 0.05603333 5.169458e-01 8.584201e-09 FALSE TRUE
ENST00000393387 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 0.2325864 0.31302314 0.0000000 0.16422455 0.00000000 -5.0135656 0.07583750 0.34140000 0.00000000 -0.34140000 3.474601e-02 8.584201e-09 FALSE TRUE
ENST00000481385 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 2.3288303 0.00000000 4.1184804 0.00000000 0.28862302 8.6894671 0.13020417 0.00000000 0.22896667 0.22896667 8.584201e-09 8.584201e-09 FALSE TRUE
ENST00000505138 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 0.3799882 0.19812656 0.5653936 0.10300119 0.11082291 1.4670881 0.05590417 0.13630000 0.03216667 -0.10413333 1.686996e-01 8.584201e-09 FALSE TRUE
ENST00000506783 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 4.2778108 0.19494781 7.5480432 0.11335488 0.25601086 5.2046843 0.35772917 0.13873333 0.42036667 0.28163333 7.537549e-02 8.584201e-09 FALSE TRUE
ENST00000509330 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 0.4092226 0.05871830 0.6206549 0.02940734 0.12249354 3.1980845 0.05126250 0.05880000 0.03393333 -0.02486667 7.384054e-01 8.584201e-09 FALSE TRUE
ENST00000515594 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding protein_coding 10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 0.1702369 0.08377012 0.1491251 0.04361481 0.05430268 0.7629611 0.04750000 0.07813333 0.00810000 -0.07003333 2.887959e-02 8.584201e-09 FALSE TRUE
MSTRG.28465.1 ENSG00000118482 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF3 protein_coding   10.34847 1.213054 18.01594 0.2375211 0.9041118 3.881515 0.1438310 0.10769335 0.0000000 0.10769335 0.00000000 -3.5569609 0.08072917 0.07993333 0.00000000 -0.07993333 2.586229e-01 8.584201e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118482 E001 0.0000000       6 63635746 63635801 56 +      
ENSG00000118482 E002 1.0478088 0.1599323967 4.896947e-01 6.270909e-01 6 63635802 63635819 18 + 0.231 0.000 -9.960
ENSG00000118482 E003 1.0478088 0.1599323967 4.896947e-01 6.270909e-01 6 63635820 63635822 3 + 0.231 0.000 -11.460
ENSG00000118482 E004 1.0478088 0.1599323967 4.896947e-01 6.270909e-01 6 63635823 63635824 2 + 0.231 0.000 -11.460
ENSG00000118482 E005 2.0162220 0.1039279550 6.898423e-01 7.916584e-01 6 63635825 63635835 11 + 0.343 0.316 -0.170
ENSG00000118482 E006 7.7915680 0.0186919792 3.986217e-01 5.423484e-01 6 63635836 63635881 46 + 0.756 0.721 -0.143
ENSG00000118482 E007 23.7103913 0.0007935707 2.551519e-02 6.294226e-02 6 63635882 63636110 229 + 1.195 1.065 -0.469
ENSG00000118482 E008 21.2289889 0.0009795673 5.899551e-03 1.834504e-02 6 63636111 63636150 40 + 1.158 0.926 -0.849
ENSG00000118482 E009 0.4482035 0.0266583731 1.000000e+00 1.000000e+00 6 63636481 63636822 342 + 0.114 0.000 -10.915
ENSG00000118482 E010 0.0000000       6 63646526 63646526 1 +      
ENSG00000118482 E011 22.1252797 0.0008713999 5.226310e-02 1.131876e-01 6 63646527 63646618 92 + 1.164 1.065 -0.356
ENSG00000118482 E012 39.5591184 0.0005545630 4.256774e-04 1.872839e-03 6 63646619 63646795 177 + 1.411 1.200 -0.737
ENSG00000118482 E013 3.8704331 0.0427688778 5.791200e-01 7.040890e-01 6 63678828 63679020 193 + 0.519 0.496 -0.108
ENSG00000118482 E014 0.0000000       6 63679685 63679891 207 +      
ENSG00000118482 E015 63.1392668 0.0003874883 2.881322e-05 1.721406e-04 6 63680000 63680161 162 + 1.608 1.423 -0.635
ENSG00000118482 E016 385.9243232 0.0009409673 8.719362e-26 1.027913e-23 6 63684129 63685911 1783 + 2.388 2.181 -0.690
ENSG00000118482 E017 4.2868187 0.0112353025 4.732664e-02 1.044112e-01 6 63685912 63686324 413 + 0.477 0.926 1.896
ENSG00000118482 E018 97.8117273 0.0024628747 7.539089e-04 3.093744e-03 6 63691737 63692043 307 + 1.785 1.716 -0.231
ENSG00000118482 E019 23.5642194 0.0061309930 1.208214e-01 2.211247e-01 6 63694581 63694583 3 + 1.187 1.138 -0.173
ENSG00000118482 E020 78.4887529 0.0006684083 2.945470e-03 1.010358e-02 6 63694584 63694764 181 + 1.690 1.638 -0.175
ENSG00000118482 E021 64.1975107 0.0010987581 2.293313e-02 5.760613e-02 6 63698223 63698367 145 + 1.601 1.581 -0.068
ENSG00000118482 E022 45.4558584 0.0005059274 4.905209e-01 6.278687e-01 6 63698449 63698605 157 + 1.442 1.530 0.303
ENSG00000118482 E023 38.2394858 0.0007550303 2.033142e-01 3.303481e-01 6 63700350 63700466 117 + 1.376 1.405 0.100
ENSG00000118482 E024 0.1515154 0.0426577003 7.312370e-01   6 63702293 63702427 135 + 0.041 0.000 -9.205
ENSG00000118482 E025 59.9708677 0.0004104438 6.660277e-03 2.033997e-02 6 63702508 63702639 132 + 1.576 1.516 -0.204
ENSG00000118482 E026 69.6958895 0.0003598881 9.177175e-03 2.672572e-02 6 63703536 63703671 136 + 1.639 1.605 -0.116
ENSG00000118482 E027 80.3960235 0.0004437331 1.237254e-01 2.252598e-01 6 63706029 63706224 196 + 1.690 1.741 0.172
ENSG00000118482 E028 46.7578462 0.0004487523 3.609028e-01 5.052836e-01 6 63706729 63706799 71 + 1.459 1.530 0.244
ENSG00000118482 E029 56.0315535 0.0004632759 6.318602e-01 7.468152e-01 6 63706800 63706876 77 + 1.528 1.638 0.374
ENSG00000118482 E030 55.9482938 0.0004417834 3.250810e-01 4.685107e-01 6 63709151 63709240 90 + 1.532 1.605 0.248
ENSG00000118482 E031 73.6433716 0.0003832107 8.485553e-01 9.059735e-01 6 63711167 63711362 196 + 1.641 1.773 0.449
ENSG00000118482 E032 767.8638457 0.0096378614 1.294441e-16 5.493459e-15 6 63711586 63726011 14426 + 2.605 3.008 1.339
ENSG00000118482 E033 0.7490443 0.0761202187 7.009083e-01 8.002663e-01 6 63777605 63778065 461 + 0.176 0.000 -11.275
ENSG00000118482 E034 1.4488820 0.0117605183 3.758908e-01 5.202811e-01 6 63778066 63778243 178 + 0.230 0.495 1.603
ENSG00000118482 E035 0.3666179 0.0279189272 1.449258e-01 2.547389e-01 6 63779138 63779336 199 + 0.041 0.314 3.412