ENSG00000118454

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262346 ENSG00000118454 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13C protein_coding protein_coding 16.86926 5.137714 28.88594 0.3970436 1.186089 2.488863 2.9058081 2.0285758 4.9324075 0.1788761 0.49483076 1.277652 0.21324583 0.39830000 0.1724667 -0.22583333 5.267299e-04 1.464845e-10 FALSE TRUE
ENST00000370944 ENSG00000118454 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13C protein_coding protein_coding 16.86926 5.137714 28.88594 0.3970436 1.186089 2.488863 3.4508470 1.4492630 5.7689718 0.1749568 0.34913347 1.985573 0.23845833 0.28020000 0.1994667 -0.08073333 3.433306e-02 1.464845e-10 FALSE TRUE
ENST00000464236 ENSG00000118454 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13C protein_coding processed_transcript 16.86926 5.137714 28.88594 0.3970436 1.186089 2.488863 0.6994801 0.3614669 0.7748341 0.2829394 0.07685415 1.079154 0.05030833 0.06563333 0.0267000 -0.03893333 9.413285e-01 1.464845e-10 FALSE FALSE
MSTRG.1391.5 ENSG00000118454 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13C protein_coding   16.86926 5.137714 28.88594 0.3970436 1.186089 2.488863 2.7314381 0.7186296 5.1257031 0.3783774 0.51328170 2.817304 0.15533750 0.14473333 0.1775333 0.03280000 8.177663e-01 1.464845e-10 TRUE TRUE
MSTRG.1391.6 ENSG00000118454 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13C protein_coding   16.86926 5.137714 28.88594 0.3970436 1.186089 2.488863 3.4511309 0.0000000 5.8318804 0.0000000 1.25783057 9.190289 0.15402083 0.00000000 0.1992000 0.19920000 1.464845e-10 1.464845e-10 FALSE TRUE
MSTRG.1391.8 ENSG00000118454 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD13C protein_coding   16.86926 5.137714 28.88594 0.3970436 1.186089 2.488863 2.5058980 0.2775879 5.0263583 0.1627989 0.33203375 4.130306 0.09947917 0.05436667 0.1745000 0.12013333 2.000620e-01 1.464845e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118454 E001 172.9072614 0.0022186731 7.914500e-03 2.356402e-02 1 70258999 70261236 2238 - 2.145 2.245 0.332
ENSG00000118454 E002 219.7949292 0.0004656855 2.065158e-12 4.812868e-11 1 70261237 70262273 1037 - 2.223 2.412 0.632
ENSG00000118454 E003 44.7051468 0.0005142280 6.116708e-07 5.320196e-06 1 70262274 70262458 185 - 1.506 1.789 0.960
ENSG00000118454 E004 18.5071840 0.0010141682 1.873346e-02 4.874930e-02 1 70262459 70262468 10 - 1.166 1.372 0.722
ENSG00000118454 E005 38.4897423 0.0039325170 1.115526e-05 7.330574e-05 1 70262469 70262546 78 - 1.439 1.731 0.995
ENSG00000118454 E006 32.7056448 0.0006784643 3.533037e-06 2.603763e-05 1 70262547 70262565 19 - 1.366 1.669 1.041
ENSG00000118454 E007 161.1449621 0.0088157366 8.895552e-01 9.333900e-01 1 70262566 70262803 238 - 2.136 2.144 0.025
ENSG00000118454 E008 85.9017528 0.0067249330 2.628406e-01 4.006595e-01 1 70262804 70262847 44 - 1.883 1.812 -0.239
ENSG00000118454 E009 80.7210626 0.0003251357 1.156692e-01 2.137788e-01 1 70270856 70270956 101 - 1.858 1.784 -0.248
ENSG00000118454 E010 107.9039732 0.0003631232 6.674136e-01 7.746483e-01 1 70274720 70274818 99 - 1.971 1.956 -0.050
ENSG00000118454 E011 112.7159461 0.0002688478 1.834980e-01 3.055913e-01 1 70276765 70276844 80 - 1.998 1.947 -0.171
ENSG00000118454 E012 0.7362571 0.0509363618 3.443231e-01 4.884020e-01 1 70292146 70292387 242 - 0.174 0.358 1.375
ENSG00000118454 E013 151.2248785 0.0002885329 8.827835e-04 3.553776e-03 1 70292388 70292549 162 - 2.138 2.022 -0.390
ENSG00000118454 E014 4.3189873 0.0037503320 3.552208e-01 4.995881e-01 1 70293504 70293620 117 - 0.709 0.553 -0.677
ENSG00000118454 E015 123.3031010 0.0011482397 7.719981e-05 4.147955e-04 1 70296130 70296261 132 - 2.061 1.893 -0.563
ENSG00000118454 E016 109.7259080 0.0039013294 1.207580e-01 2.210405e-01 1 70300764 70300908 145 - 1.994 1.919 -0.254
ENSG00000118454 E017 1.9240417 0.0072294543 2.086884e-01 3.369280e-01 1 70305686 70305957 272 - 0.473 0.216 -1.618
ENSG00000118454 E018 63.7678792 0.0007518274 6.560775e-01 7.658025e-01 1 70306224 70306290 67 - 1.752 1.730 -0.072
ENSG00000118454 E019 0.7385489 0.0388000070 2.966888e-01 4.379455e-01 1 70307247 70307359 113 - 0.261 0.000 -9.676
ENSG00000118454 E020 53.1257117 0.0004578501 4.876106e-01 6.252735e-01 1 70313745 70313790 46 - 1.657 1.698 0.139
ENSG00000118454 E021 79.6557841 0.0004198051 1.416350e-02 3.859601e-02 1 70315481 70315566 86 - 1.865 1.746 -0.401
ENSG00000118454 E022 92.1650319 0.0002826559 7.939090e-07 6.738215e-06 1 70324853 70324957 105 - 1.945 1.709 -0.797
ENSG00000118454 E023 61.7498794 0.0003625158 4.205169e-07 3.776877e-06 1 70336058 70336099 42 - 1.783 1.477 -1.044
ENSG00000118454 E024 249.9925096 0.0017454127 9.373702e-01 9.646317e-01 1 70353979 70354734 756 - 2.330 2.329 -0.006