ENSG00000118412

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237177 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding processed_transcript 8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 0.12441132 0.2846588 0.0000000 0.2846588 0.00000000 -4.8809734 0.07369583 0.1362000 0.00000000 -0.13620000 4.563352e-01 9.198487e-27 FALSE TRUE
ENST00000548224 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding processed_transcript 8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 0.29982779 0.6912848 0.1604874 0.3900103 0.08797962 -2.0403356 0.09760417 0.3459333 0.01060000 -0.33533333 2.302812e-01 9.198487e-27 FALSE TRUE
ENST00000551025 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding protein_coding 8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 2.57628316 0.0000000 4.5534445 0.0000000 0.01076184 8.8339794 0.16624583 0.0000000 0.30186667 0.30186667 8.449504e-18 9.198487e-27 FALSE TRUE
ENST00000552401 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding protein_coding 8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 0.44716257 0.0000000 0.9399384 0.0000000 0.15931708 6.5697621 0.02935417 0.0000000 0.06226667 0.06226667 2.160526e-03 9.198487e-27 FALSE TRUE
MSTRG.28638.1 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding   8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 4.20828143 0.0000000 8.1707107 0.0000000 0.30541846 9.6760824 0.45375000 0.0000000 0.54156667 0.54156667 9.198487e-27 9.198487e-27 FALSE TRUE
MSTRG.28638.2 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding   8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 0.08742117 0.3980775 0.0000000 0.3980775 0.00000000 -5.3507713 0.03942500 0.2979000 0.00000000 -0.29790000 3.253038e-01 9.198487e-27 FALSE TRUE
MSTRG.28638.7 ENSG00000118412 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP8AP2 protein_coding   8.889585 1.792924 15.08473 0.2317435 0.0757698 3.065634 0.48413750 0.3592536 0.2371498 0.1818531 0.11878479 -0.5792262 0.07538333 0.1785000 0.01580000 -0.16270000 3.505381e-01 9.198487e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118412 E001 0.2987644 0.0271650215 1.000000e+00   6 89829869 89829880 12 + 0.074 0.000 -7.491
ENSG00000118412 E002 0.4460135 0.0300973129 1.000000e+00 1.000000e+00 6 89829881 89829887 7 + 0.107 0.000 -9.086
ENSG00000118412 E003 0.5911862 0.0185109484 1.000000e+00 1.000000e+00 6 89829888 89829893 6 + 0.138 0.000 -9.609
ENSG00000118412 E004 1.1909051 0.0105659031 5.755809e-01 7.011495e-01 6 89829894 89829899 6 + 0.242 0.000 -10.641
ENSG00000118412 E005 7.7497403 0.0025929843 4.501993e-02 1.002396e-01 6 89829900 89829930 31 + 0.760 0.330 -2.064
ENSG00000118412 E006 9.2267244 0.0018470131 1.980513e-02 5.107016e-02 6 89829931 89829934 4 + 0.825 0.330 -2.323
ENSG00000118412 E007 7.1585541 0.0027546420 6.222404e-02 1.303884e-01 6 89829935 89829938 4 + 0.731 0.330 -1.947
ENSG00000118412 E008 8.1809920 0.0020582493 3.512377e-02 8.187838e-02 6 89829939 89829940 2 + 0.781 0.330 -2.147
ENSG00000118412 E009 25.3691856 0.0007396621 3.146587e-03 1.069719e-02 6 89829941 89830067 127 + 1.214 0.825 -1.436
ENSG00000118412 E010 3.8355103 0.0039913248 5.453761e-01 6.757260e-01 6 89830068 89830106 39 + 0.484 0.644 0.734
ENSG00000118412 E011 5.8974892 0.0707163447 9.280021e-01 9.586783e-01 6 89830107 89831339 1233 + 0.640 0.645 0.023
ENSG00000118412 E012 2.3398768 0.0072741672 1.660215e-01 2.830249e-01 6 89832264 89832320 57 + 0.326 0.644 1.608
ENSG00000118412 E013 29.9529480 0.0007098898 4.717819e-03 1.514475e-02 6 89846562 89846644 83 + 1.278 0.952 -1.177
ENSG00000118412 E014 30.6615380 0.0006896816 1.077411e-05 7.105736e-05 6 89853166 89853234 69 + 1.299 0.644 -2.472
ENSG00000118412 E015 13.9052615 0.0012909100 8.564083e-05 4.546305e-04 6 89854817 89854820 4 + 0.989 0.000 -13.427
ENSG00000118412 E016 35.0412450 0.0007046697 3.812316e-05 2.208660e-04 6 89854821 89854917 97 + 1.351 0.825 -1.916
ENSG00000118412 E017 33.5675056 0.0014401468 8.857632e-03 2.592627e-02 6 89855470 89855544 75 + 1.323 1.050 -0.970
ENSG00000118412 E018 38.9025360 0.0005648346 6.059308e-02 1.276325e-01 6 89857084 89857199 116 + 1.377 1.228 -0.521
ENSG00000118412 E019 0.4375944 0.0274075362 1.000000e+00 1.000000e+00 6 89857200 89857349 150 + 0.107 0.000 -9.112
ENSG00000118412 E020 2.0994034 0.0070320162 4.711993e-01 6.103413e-01 6 89861416 89861563 148 + 0.326 0.515 1.023
ENSG00000118412 E021 405.8393279 0.0024989062 5.464733e-17 2.423969e-15 6 89862126 89864371 2246 + 2.386 2.121 -0.885
ENSG00000118412 E022 590.3198913 0.0004495376 1.358969e-03 5.173056e-03 6 89865953 89869082 3130 + 2.517 2.628 0.372
ENSG00000118412 E023 49.7853650 0.0006002345 6.184401e-07 5.372169e-06 6 89871289 89871388 100 + 1.416 1.803 1.318
ENSG00000118412 E024 76.0610861 0.0456915196 6.738542e-13 1.701221e-11 6 89873806 89874436 631 + 1.477 2.283 2.721