ENSG00000118307

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320267 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding protein_coding 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.052220133 0.00000000 0.12945612 0.00000000 0.12945612 3.801739 0.14874583 0.00000000 0.3062333 0.30623333 1.000000000 0.008929218 FALSE TRUE
ENST00000354189 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding protein_coding 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.018203277 0.01483170 0.00000000 0.01483170 0.00000000 -1.312183 0.08297500 0.09436667 0.0000000 -0.09436667 0.446195257 0.008929218 FALSE TRUE
ENST00000545133 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding protein_coding 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.015692369 0.09429872 0.00000000 0.03361955 0.00000000 -3.382650 0.13991667 0.78600000 0.0000000 -0.78600000 0.008929218 0.008929218 FALSE TRUE
ENST00000555240 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding retained_intron 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.023678533 0.00000000 0.12499488 0.00000000 0.12499488 3.754833 0.03154167 0.00000000 0.1464000 0.14640000 1.000000000 0.008929218   FALSE
ENST00000556006 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding protein_coding 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.005260607 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.12500000 0.00000000 0.0000000 0.00000000   0.008929218 FALSE TRUE
ENST00000556547 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding retained_intron 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.012735631 0.01879841 0.00000000 0.01879841 0.00000000 -1.525989 0.06694583 0.11960000 0.0000000 -0.11960000 0.365706653 0.008929218 FALSE FALSE
ENST00000557684 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding nonsense_mediated_decay 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.031489496 0.00000000 0.23016519 0.00000000 0.11522955 4.585955 0.09556667 0.00000000 0.4312000 0.43120000 0.499648850 0.008929218 TRUE TRUE
ENST00000674567 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding protein_coding 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.016439893 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.09207500 0.00000000 0.0000000 0.00000000   0.008929218 FALSE TRUE
ENST00000676236 ENSG00000118307 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAI7 protein_coding protein_coding 0.2581576 0.1279288 0.5528524 0.03134131 0.1509701 2.028833 0.055467340 0.00000000 0.02494626 0.00000000 0.02494626 1.805138 0.12542083 0.00000000 0.0292000 0.02920000 1.000000000 0.008929218 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118307 E001 0.0000000       12 25108289 25108419 131 -      
ENSG00000118307 E002 0.0000000       12 25108420 25108420 1 -      
ENSG00000118307 E003 0.0000000       12 25108421 25108423 3 -      
ENSG00000118307 E004 0.0000000       12 25108424 25108435 12 -      
ENSG00000118307 E005 0.0000000       12 25108436 25108476 41 -      
ENSG00000118307 E006 1.5707852 0.023070110 0.312202250 0.454740166 12 25108477 25108761 285 - 0.361 0.471 0.596
ENSG00000118307 E007 1.0923927 0.025103139 0.315807502 0.458576650 12 25108762 25108823 62 - 0.270 0.392 0.765
ENSG00000118307 E008 0.9472200 0.020547031 0.197481813 0.323060438 12 25110127 25110240 114 - 0.217 0.392 1.180
ENSG00000118307 E009 0.5922303 0.019083610 1.000000000 1.000000000 12 25111772 25111816 45 - 0.217 0.173 -0.406
ENSG00000118307 E010 1.6713714 0.010783109 0.308026222 0.450256890 12 25111817 25111939 123 - 0.361 0.472 0.597
ENSG00000118307 E011 2.4485152 0.008434337 0.484150352 0.622165157 12 25114656 25114870 215 - 0.500 0.538 0.181
ENSG00000118307 E012 0.1515154 0.044525258 1.000000000   12 25114871 25114913 43 - 0.085 0.000 -11.278
ENSG00000118307 E013 0.5138669 0.023089297 0.748201878 0.835497024 12 25119145 25119158 14 - 0.156 0.173 0.183
ENSG00000118307 E014 1.2639554 0.012010932 0.977659324 0.990108831 12 25119159 25119301 143 - 0.361 0.297 -0.405
ENSG00000118307 E015 1.0695787 0.012188474 0.471361374 0.610492207 12 25121753 25121913 161 - 0.361 0.173 -1.404
ENSG00000118307 E016 1.4017517 0.011187479 0.134593186 0.240545229 12 25123211 25123286 76 - 0.271 0.472 1.183
ENSG00000118307 E017 2.6980611 0.012150663 0.600656989 0.721865201 12 25144365 25144677 313 - 0.529 0.539 0.048
ENSG00000118307 E018 2.2477958 0.007299710 0.784367352 0.861687374 12 25147001 25147104 104 - 0.500 0.471 -0.140
ENSG00000118307 E019 2.1026231 0.007321772 0.658488533 0.767603224 12 25149628 25149761 134 - 0.469 0.471 0.012
ENSG00000118307 E020 1.1426289 0.011993234 0.314994045 0.457740218 12 25149762 25149774 13 - 0.271 0.393 0.766
ENSG00000118307 E021 1.2835352 0.023737490 0.458005354 0.598338131 12 25154319 25154340 22 - 0.318 0.393 0.445
ENSG00000118307 E022 1.5822997 0.016582397 0.748659494 0.835820963 12 25154341 25154374 34 - 0.400 0.393 -0.041
ENSG00000118307 E023 2.2624584 0.021902551 0.618400662 0.736045475 12 25154375 25154456 82 - 0.556 0.392 -0.823
ENSG00000118307 E024 3.1525227 0.005746056 0.199418469 0.325517458 12 25155311 25155412 102 - 0.689 0.393 -1.406
ENSG00000118307 E025 2.6678892 0.005853132 0.001743446 0.006419142 12 25158472 25158563 92 - 0.689 0.000 -15.447
ENSG00000118307 E026 0.3332198 0.029222364 0.430528556   12 25158564 25158689 126 - 0.085 0.173 1.181
ENSG00000118307 E027 0.1817044 0.041362036 0.158101765   12 25158690 25158737 48 - 0.000 0.173 13.364
ENSG00000118307 E028 0.1515154 0.044525258 1.000000000   12 25161077 25161112 36 - 0.085 0.000 -11.278
ENSG00000118307 E029 2.2197994 0.008317126 0.005056081 0.016085251 12 25161113 25161197 85 - 0.628 0.000 -15.184
ENSG00000118307 E030 0.0000000       12 25185749 25185786 38 -      
ENSG00000118307 E031 0.1472490 0.049234521 1.000000000   12 25190614 25190631 18 - 0.085 0.000 -11.277
ENSG00000118307 E032 0.0000000       12 25192694 25192826 133 -      
ENSG00000118307 E033 0.1817044 0.041362036 0.158101765   12 25194886 25195057 172 - 0.000 0.173 13.364
ENSG00000118307 E034 0.0000000       12 25195058 25195075 18 -      
ENSG00000118307 E035 1.4749078 0.010113465 0.028168585 0.068343351 12 25195076 25195162 87 - 0.500 0.000 -14.599