ENSG00000118276

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237019 ENSG00000118276 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT6 protein_coding protein_coding 8.52468 1.726856 12.26777 0.2688208 0.6064723 2.821499 0.5394825 0.00000000 0.6196759 0.00000000 0.3109219 5.976538 0.03614583 0.0000000 0.05183333 0.05183333 5.326945e-01 3.254685e-16 FALSE TRUE
ENST00000306851 ENSG00000118276 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT6 protein_coding protein_coding 8.52468 1.726856 12.26777 0.2688208 0.6064723 2.821499 4.5813948 1.67937194 6.8751591 0.24152660 0.3301125 2.027003 0.70351667 0.9765333 0.56106667 -0.41546667 3.254685e-16 3.254685e-16 FALSE TRUE
MSTRG.15649.3 ENSG00000118276 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT6 protein_coding   8.52468 1.726856 12.26777 0.2688208 0.6064723 2.821499 1.8020220 0.01158029 2.3140154 0.01158029 0.2776873 6.750761 0.14043333 0.0054000 0.18896667 0.18356667 3.678953e-07 3.254685e-16 TRUE TRUE
MSTRG.15649.4 ENSG00000118276 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALT6 protein_coding   8.52468 1.726856 12.26777 0.2688208 0.6064723 2.821499 1.1447714 0.00000000 1.9495973 0.00000000 0.3296349 7.614413 0.07278750 0.0000000 0.15713333 0.15713333 6.019110e-07 3.254685e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118276 E001 0.9232720 0.0142371342 6.950692e-03 2.109493e-02 18 31622246 31622246 1 - 0.108 0.602 3.411
ENSG00000118276 E002 68.0534748 0.0046976355 3.065036e-34 7.133439e-32 18 31622247 31622755 509 - 1.515 2.171 2.216
ENSG00000118276 E003 87.2602094 0.0021742487 1.921383e-13 5.251013e-12 18 31622756 31622983 228 - 1.749 2.101 1.183
ENSG00000118276 E004 182.4466072 0.0002876921 1.974490e-11 3.915642e-10 18 31622984 31624662 1679 - 2.110 2.322 0.707
ENSG00000118276 E005 131.3335441 0.0002742609 2.213713e-05 1.358364e-04 18 31624663 31625484 822 - 2.037 1.886 -0.507
ENSG00000118276 E006 32.5465191 0.0016789960 1.277576e-03 4.902726e-03 18 31625485 31625543 59 - 1.457 1.184 -0.952
ENSG00000118276 E007 60.7257947 0.0006283507 5.486853e-04 2.342102e-03 18 31625544 31625761 218 - 1.711 1.513 -0.677
ENSG00000118276 E008 43.3142755 0.0005841005 8.271762e-05 4.408666e-04 18 31626283 31626384 102 - 1.582 1.296 -0.986
ENSG00000118276 E009 0.0000000       18 31626989 31626998 10 -      
ENSG00000118276 E010 41.7198791 0.0066665887 3.239755e-03 1.097140e-02 18 31626999 31627121 123 - 1.562 1.327 -0.812
ENSG00000118276 E011 55.7854984 0.0035570528 3.854690e-05 2.230617e-04 18 31630959 31631146 188 - 1.688 1.399 -0.991
ENSG00000118276 E012 42.6898806 0.0005854208 2.344420e-05 1.430552e-04 18 31638644 31638760 117 - 1.579 1.262 -1.096
ENSG00000118276 E013 48.5522526 0.0005001167 1.305229e-07 1.296789e-06 18 31645355 31645479 125 - 1.638 1.244 -1.360
ENSG00000118276 E014 0.1451727 0.0440893732 1.000000e+00   18 31657975 31657975 1 - 0.057 0.000 -9.293
ENSG00000118276 E015 44.4214826 0.0055643419 3.965582e-04 1.761100e-03 18 31657976 31658089 114 - 1.590 1.312 -0.959
ENSG00000118276 E016 0.1482932 0.0411597534 7.648713e-02   18 31658090 31658464 375 - 0.000 0.243 12.062
ENSG00000118276 E017 41.4659045 0.0006249860 3.930106e-06 2.863201e-05 18 31666256 31666372 117 - 1.569 1.205 -1.264
ENSG00000118276 E018 42.1749455 0.0006065313 7.692306e-08 7.985995e-07 18 31684312 31684581 270 - 1.584 1.139 -1.548
ENSG00000118276 E019 0.0000000       18 31685730 31687915 2186 -