ENSG00000118246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000236980 ENSG00000118246 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD2 protein_coding protein_coding 11.6394 3.100656 18.61571 0.070838 0.7997424 2.582004 2.186883 0.6105368 3.6607486 0.07359030 0.42547316 2.5644857 0.20370833 0.1982000 0.19933333 0.001133333 1.000000e+00 5.626024e-08 FALSE TRUE
ENST00000402774 ENSG00000118246 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD2 protein_coding protein_coding 11.6394 3.100656 18.61571 0.070838 0.7997424 2.582004 2.909066 1.2575989 4.5365452 0.23892165 0.46276743 1.8426724 0.31417083 0.4051000 0.24266667 -0.162433333 1.454392e-01 5.626024e-08 FALSE TRUE
ENST00000418289 ENSG00000118246 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD2 protein_coding protein_coding 11.6394 3.100656 18.61571 0.070838 0.7997424 2.582004 5.575087 0.5746484 9.0330006 0.30339389 0.75033346 3.9511603 0.34578333 0.1834667 0.48350000 0.300033333 3.715696e-01 5.626024e-08 FALSE FALSE
ENST00000471788 ENSG00000118246 HEK293_OSMI2_2hA HEK293_TMG_2hB FASTKD2 protein_coding retained_intron 11.6394 3.100656 18.61571 0.070838 0.7997424 2.582004 0.641986 0.5689137 0.8555967 0.02525889 0.02556322 0.5803467 0.09260417 0.1840333 0.04626667 -0.137766667 5.626024e-08 5.626024e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118246 E001 0.147249 0.0438879990 1.000000e+00   2 206765357 206765364 8 + 0.068 0.000 -7.358
ENSG00000118246 E002 6.951752 0.0874691784 3.975283e-01 5.412846e-01 2 206765365 206765518 154 + 0.880 0.682 -0.793
ENSG00000118246 E003 10.666853 0.0180152925 3.815141e-01 5.258055e-01 2 206765519 206765605 87 + 1.032 0.900 -0.495
ENSG00000118246 E004 44.762653 0.0155617370 8.722768e-03 2.559281e-02 2 206765606 206765646 41 + 1.647 1.386 -0.896
ENSG00000118246 E005 46.311772 0.0115182779 2.287652e-03 8.112840e-03 2 206765647 206765654 8 + 1.665 1.385 -0.959
ENSG00000118246 E006 37.457224 0.0006067164 2.359810e-02 5.898263e-02 2 206765655 206765747 93 + 1.557 1.385 -0.590
ENSG00000118246 E007 2.294926 0.0065552762 4.572641e-01 5.976193e-01 2 206765748 206765762 15 + 0.504 0.354 -0.800
ENSG00000118246 E008 334.143706 0.0020741604 3.497601e-07 3.191763e-06 2 206766644 206767470 827 + 2.495 2.329 -0.552
ENSG00000118246 E009 110.797427 0.0034845913 1.103732e-02 3.125027e-02 2 206770091 206770194 104 + 2.013 1.873 -0.469
ENSG00000118246 E010 123.174923 0.0002972137 1.126960e-04 5.802711e-04 2 206771182 206771290 109 + 2.063 1.901 -0.545
ENSG00000118246 E011 125.907491 0.0003366181 1.229078e-03 4.739367e-03 2 206771894 206772017 124 + 2.068 1.934 -0.451
ENSG00000118246 E012 108.619391 0.0009903360 2.821677e-02 6.844655e-02 2 206772181 206772320 140 + 2.000 1.897 -0.346
ENSG00000118246 E013 122.503577 0.0007580031 5.919006e-01 7.145693e-01 2 206774225 206774397 173 + 2.038 2.009 -0.097
ENSG00000118246 E014 0.000000       2 206786614 206786732 119 +      
ENSG00000118246 E015 123.092011 0.0003442566 2.392358e-02 5.964468e-02 2 206786733 206786899 167 + 2.014 2.087 0.244
ENSG00000118246 E016 136.552555 0.0002586188 9.177393e-12 1.924540e-10 2 206787937 206788155 219 + 2.016 2.227 0.708
ENSG00000118246 E017 93.871476 0.0002891100 4.716672e-12 1.035411e-10 2 206788819 206788903 85 + 1.838 2.096 0.867
ENSG00000118246 E018 3.304036 0.0086925565 4.084995e-01 5.521042e-01 2 206788904 206790571 1668 + 0.547 0.679 0.578
ENSG00000118246 E019 99.787669 0.0002965114 2.741138e-15 9.801819e-14 2 206790572 206790686 115 + 1.855 2.140 0.957
ENSG00000118246 E020 12.416960 0.0014319203 5.610921e-02 1.198944e-01 2 206790687 206791682 996 + 1.018 1.206 0.678
ENSG00000118246 E021 252.408438 0.0041226564 4.917293e-02 1.076856e-01 2 206791683 206796189 4507 + 2.325 2.392 0.223