ENSG00000118200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000236925 ENSG00000118200 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP2 protein_coding protein_coding 7.367121 3.110725 10.61841 0.02986463 0.3488089 1.767973 0.6761209 0.6137444 1.2752483 0.30886140 0.7133774 1.043020 0.1171167 0.19606667 0.11853333 -0.07753333 0.925092392 0.002007779 FALSE TRUE
ENST00000358823 ENSG00000118200 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP2 protein_coding protein_coding 7.367121 3.110725 10.61841 0.02986463 0.3488089 1.767973 2.9082769 0.4118251 4.6295381 0.13065075 0.3601554 3.459264 0.3213750 0.13233333 0.43780000 0.30546667 0.002007779 0.002007779 FALSE TRUE
ENST00000413307 ENSG00000118200 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP2 protein_coding protein_coding 7.367121 3.110725 10.61841 0.02986463 0.3488089 1.767973 3.3799447 1.9643621 4.3466134 0.36114923 0.4540459 1.141820 0.4999292 0.63283333 0.40903333 -0.22380000 0.357804588 0.002007779 FALSE TRUE
ENST00000475326 ENSG00000118200 HEK293_OSMI2_2hA HEK293_TMG_2hB CAMSAP2 protein_coding protein_coding 7.367121 3.110725 10.61841 0.02986463 0.3488089 1.767973 0.2868291 0.1207937 0.2059398 0.06165618 0.1357570 0.723336 0.0519250 0.03876667 0.01863333 -0.02013333 0.748347023 0.002007779   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118200 E001 39.5281449 0.0059757859 7.465069e-06 5.104385e-05 1 200738893 200739778 886 + 1.556 1.290 -0.919
ENSG00000118200 E002 32.6054449 0.0081656063 7.612073e-04 3.119639e-03 1 200739779 200739966 188 + 1.466 1.273 -0.668
ENSG00000118200 E003 61.5546900 0.0004310480 9.103992e-07 7.624100e-06 1 200760839 200761098 260 + 1.732 1.562 -0.579
ENSG00000118200 E004 52.5235301 0.0005275525 6.033658e-05 3.330881e-04 1 200807376 200807537 162 + 1.659 1.527 -0.452
ENSG00000118200 E005 38.9364846 0.0005712672 2.979197e-03 1.020190e-02 1 200815561 200815644 84 + 1.528 1.435 -0.317
ENSG00000118200 E006 0.5806908 0.7848938400 8.287935e-01 8.924357e-01 1 200828573 200828605 33 + 0.202 0.001 -8.731
ENSG00000118200 E007 0.0000000       1 200832108 200832199 92 +      
ENSG00000118200 E008 41.4196211 0.0005423007 8.443552e-03 2.489387e-02 1 200832200 200832341 142 + 1.548 1.488 -0.205
ENSG00000118200 E009 9.4614281 0.0018057101 2.677693e-01 4.061148e-01 1 200832706 200832715 10 + 0.943 0.908 -0.130
ENSG00000118200 E010 34.7561964 0.0006194233 4.244985e-02 9.553516e-02 1 200832716 200832845 130 + 1.466 1.435 -0.104
ENSG00000118200 E011 45.5220719 0.0007179037 1.334858e-05 8.613144e-05 1 200841994 200842087 94 + 1.606 1.424 -0.626
ENSG00000118200 E012 37.9703923 0.0006424309 1.162822e-07 1.167116e-06 1 200844782 200844869 88 + 1.545 1.239 -1.060
ENSG00000118200 E013 27.6283841 0.0823727232 3.205612e-02 7.596486e-02 1 200847210 200847257 48 + 1.398 1.193 -0.718
ENSG00000118200 E014 27.6610166 0.0008991169 1.561582e-04 7.745237e-04 1 200847258 200847292 35 + 1.401 1.182 -0.769
ENSG00000118200 E015 36.0891708 0.0005854462 1.149078e-03 4.468082e-03 1 200847640 200847709 70 + 1.500 1.375 -0.431
ENSG00000118200 E016 445.5236090 0.0003920483 9.628889e-02 1.848097e-01 1 200848032 200850234 2203 + 2.534 2.625 0.302
ENSG00000118200 E017 70.0908166 0.0051776823 1.456614e-02 3.951304e-02 1 200852541 200852677 137 + 1.763 1.730 -0.113
ENSG00000118200 E018 89.3689255 0.0004017080 3.517568e-03 1.177747e-02 1 200853275 200853495 221 + 1.862 1.849 -0.046
ENSG00000118200 E019 59.7337054 0.0036370378 2.293950e-02 5.762005e-02 1 200854817 200854889 73 + 1.691 1.668 -0.078
ENSG00000118200 E020 57.1952340 0.0187255317 5.383296e-01 6.697606e-01 1 200856010 200856093 84 + 1.651 1.726 0.257
ENSG00000118200 E021 44.8345706 0.0171740392 8.583241e-01 9.125729e-01 1 200856094 200856125 32 + 1.539 1.647 0.368
ENSG00000118200 E022 62.7651313 0.0081926608 8.921204e-01 9.351027e-01 1 200857306 200857424 119 + 1.677 1.807 0.439
ENSG00000118200 E023 1.4017532 0.0792379396 4.519539e-01 5.928673e-01 1 200857425 200857724 300 + 0.278 0.494 1.244
ENSG00000118200 E024 445.7876649 0.0278884784 8.372211e-07 7.070659e-06 1 200857754 200860704 2951 + 2.430 2.855 1.417