ENSG00000118193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367350 ENSG00000118193 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF14 protein_coding protein_coding 5.925573 1.30808 9.160284 0.1290815 0.2866722 2.798528 1.9685698 0.287218122 3.44387461 0.173975740 0.98826804 3.538622 0.26457917 0.209733333 0.383600000 0.17386667 6.083732e-01 3.258071e-06 FALSE TRUE
ENST00000614960 ENSG00000118193 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF14 protein_coding protein_coding 5.925573 1.30808 9.160284 0.1290815 0.2866722 2.798528 2.1270476 0.047654262 2.54519745 0.047654262 1.38172028 5.469864 0.31696250 0.043966667 0.268933333 0.22496667 6.189739e-01 3.258071e-06 FALSE TRUE
MSTRG.2809.1 ENSG00000118193 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF14 protein_coding   5.925573 1.30808 9.160284 0.1290815 0.2866722 2.798528 0.3783948 0.933892743 0.06017686 0.142064081 0.06017686 -3.749556 0.24377500 0.719233333 0.006433333 -0.71280000 3.258071e-06 3.258071e-06 FALSE TRUE
MSTRG.2809.11 ENSG00000118193 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF14 protein_coding   5.925573 1.30808 9.160284 0.1290815 0.2866722 2.798528 0.3633569 0.000000000 0.71885218 0.000000000 0.49144614 6.187554 0.03940417 0.000000000 0.082066667 0.08206667 5.706690e-01 3.258071e-06 FALSE TRUE
MSTRG.2809.12 ENSG00000118193 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF14 protein_coding   5.925573 1.30808 9.160284 0.1290815 0.2866722 2.798528 0.2551122 0.006881708 0.51213364 0.006881708 0.17822258 4.950886 0.02615000 0.005266667 0.057100000 0.05183333 2.212722e-01 3.258071e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118193 E001 0.000000       1 200551497 200551499 3 -      
ENSG00000118193 E002 50.828291 0.0855862565 1.267670e-07 1.262452e-06 1 200551500 200551873 374 - 1.282 2.156 2.970
ENSG00000118193 E003 71.465197 0.0422071566 1.492572e-09 2.142633e-08 1 200551874 200552201 328 - 1.503 2.219 2.417
ENSG00000118193 E004 123.413656 0.0003434363 2.746391e-12 6.279213e-11 1 200552202 200553378 1177 - 1.863 2.203 1.141
ENSG00000118193 E005 23.243994 0.0007943156 5.960935e-01 7.180754e-01 1 200553379 200553409 31 - 1.204 1.323 0.420
ENSG00000118193 E006 20.225015 0.0009152897 4.710077e-01 6.101807e-01 1 200553410 200553427 18 - 1.143 1.284 0.499
ENSG00000118193 E007 17.016495 0.0010843061 8.654776e-01 9.173338e-01 1 200553428 200553429 2 - 1.081 1.167 0.309
ENSG00000118193 E008 19.941227 0.0009670220 4.283919e-01 5.711742e-01 1 200553430 200553449 20 - 1.136 1.284 0.526
ENSG00000118193 E009 43.160688 0.0005112107 7.003735e-01 7.998773e-01 1 200553450 200553552 103 - 1.476 1.517 0.141
ENSG00000118193 E010 62.409652 0.0003766039 5.133255e-01 6.481557e-01 1 200553553 200553767 215 - 1.621 1.731 0.374
ENSG00000118193 E011 33.462255 0.0006444077 1.076823e-01 2.021172e-01 1 200554468 200554606 139 - 1.345 1.541 0.673
ENSG00000118193 E012 27.406218 0.0007417527 2.321665e-01 3.650123e-01 1 200555380 200555454 75 - 1.266 1.438 0.600
ENSG00000118193 E013 38.140461 0.0006831639 7.914314e-01 8.665971e-01 1 200559330 200559452 123 - 1.415 1.505 0.311
ENSG00000118193 E014 45.929034 0.0010584296 4.602255e-01 6.002805e-01 1 200560722 200560880 159 - 1.502 1.518 0.052
ENSG00000118193 E015 47.673648 0.0005534589 4.196924e-01 5.629508e-01 1 200565069 200565253 185 - 1.518 1.529 0.039
ENSG00000118193 E016 51.576102 0.0005691248 2.149367e-01 3.443506e-01 1 200565445 200565669 225 - 1.559 1.541 -0.062
ENSG00000118193 E017 39.624047 0.0005558879 7.534329e-02 1.520696e-01 1 200569911 200570005 95 - 1.455 1.376 -0.273
ENSG00000118193 E018 44.159500 0.0005024540 1.589207e-02 4.249648e-02 1 200575591 200575691 101 - 1.504 1.376 -0.440
ENSG00000118193 E019 38.016493 0.0044000781 4.466132e-02 9.957816e-02 1 200580254 200580383 130 - 1.441 1.324 -0.406
ENSG00000118193 E020 31.172093 0.0126541542 9.813091e-02 1.876777e-01 1 200581201 200581294 94 - 1.356 1.244 -0.394
ENSG00000118193 E021 34.562939 0.0612199129 2.733998e-01 4.124314e-01 1 200586101 200586227 127 - 1.395 1.334 -0.211
ENSG00000118193 E022 37.819707 0.0006150035 2.923678e-01 4.333331e-01 1 200589217 200589369 153 - 1.426 1.408 -0.061
ENSG00000118193 E023 43.857128 0.0463845899 4.694735e-01 6.087135e-01 1 200590125 200590272 148 - 1.483 1.496 0.046
ENSG00000118193 E024 48.498263 0.0007814191 2.081126e-01 3.362098e-01 1 200592080 200592240 161 - 1.529 1.505 -0.080
ENSG00000118193 E025 30.320940 0.0007108170 2.757039e-01 4.150576e-01 1 200593667 200593769 103 - 1.336 1.304 -0.112
ENSG00000118193 E026 47.171727 0.0009184767 4.251729e-02 9.565897e-02 1 200598237 200598421 185 - 1.527 1.439 -0.304
ENSG00000118193 E027 28.954310 0.0008747471 2.212450e-02 5.593258e-02 1 200600050 200600113 64 - 1.331 1.167 -0.581
ENSG00000118193 E028 42.157302 0.0018570650 6.935001e-03 2.105541e-02 1 200600356 200600503 148 - 1.490 1.323 -0.575
ENSG00000118193 E029 41.149764 0.0052437937 9.637515e-02 1.849247e-01 1 200601896 200602068 173 - 1.471 1.393 -0.272
ENSG00000118193 E030 31.245996 0.0011845048 2.642388e-02 6.479323e-02 1 200603226 200603341 116 - 1.365 1.217 -0.519
ENSG00000118193 E031 35.590714 0.0005584400 4.437116e-02 9.905825e-02 1 200603839 200603955 117 - 1.415 1.304 -0.385
ENSG00000118193 E032 35.961259 0.0005922642 2.292464e-02 5.758883e-02 1 200605283 200605390 108 - 1.421 1.284 -0.475
ENSG00000118193 E033 20.758312 0.0031975985 6.235718e-02 1.306125e-01 1 200605864 200605894 31 - 1.198 1.042 -0.558
ENSG00000118193 E034 23.459918 0.0008022151 7.160657e-05 3.879558e-04 1 200606746 200606798 53 - 1.268 0.811 -1.682
ENSG00000118193 E035 25.693444 0.0017883259 2.151434e-03 7.694158e-03 1 200608830 200608928 99 - 1.295 1.005 -1.038
ENSG00000118193 E036 25.945614 0.0007690739 1.311370e-01 2.357361e-01 1 200614318 200614405 88 - 1.279 1.193 -0.305
ENSG00000118193 E037 40.300985 0.0009453168 3.744353e-03 1.242262e-02 1 200615355 200615609 255 - 1.473 1.284 -0.654
ENSG00000118193 E038 30.261981 0.0012250665 4.598769e-02 1.020120e-01 1 200617612 200617745 134 - 1.345 1.218 -0.448
ENSG00000118193 E039 63.326303 0.0008047790 2.467630e-05 1.499359e-04 1 200617746 200618179 434 - 1.667 1.424 -0.831
ENSG00000118193 E040 48.099303 0.0004934317 1.616677e-04 7.991510e-04 1 200618180 200618467 288 - 1.552 1.304 -0.855
ENSG00000118193 E041 24.074651 0.0260654333 6.739614e-02 1.390274e-01 1 200618468 200618551 84 - 1.257 1.081 -0.626
ENSG00000118193 E042 31.398954 0.0226551600 4.472794e-03 1.446545e-02 1 200618552 200618652 101 - 1.378 1.080 -1.051
ENSG00000118193 E043 32.009660 0.0006235070 3.387083e-04 1.535359e-03 1 200618653 200618838 186 - 1.387 1.077 -1.095
ENSG00000118193 E044 7.598875 0.0024574741 5.053393e-01 6.411485e-01 1 200619552 200619674 123 - 0.794 0.745 -0.198
ENSG00000118193 E045 20.928862 0.0094931292 7.660518e-02 1.540618e-01 1 200620411 200620541 131 - 1.197 1.044 -0.553
ENSG00000118193 E046 9.869374 0.0065918809 3.465088e-01 4.906280e-01 1 200620542 200620557 16 - 0.895 0.811 -0.324
ENSG00000118193 E047 15.971701 0.0012440034 3.140170e-02 7.468780e-02 1 200620558 200620711 154 - 1.097 0.868 -0.850
ENSG00000118193 E048 7.165448 0.0022436452 3.649571e-02 8.452326e-02 1 200620712 200620795 84 - 0.802 0.451 -1.552