ENSG00000118162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338134 ENSG00000118162 HEK293_OSMI2_2hA HEK293_TMG_2hB KPTN protein_coding protein_coding 24.1313 41.57242 17.99642 1.268173 1.224744 -1.207462 17.286512 32.192737 9.648374 1.5091848 0.1489400 -1.7373310 0.68433750 0.77376667 0.5409333 -0.2328333 3.120205e-05 3.120205e-05 FALSE TRUE
ENST00000594139 ENSG00000118162 HEK293_OSMI2_2hA HEK293_TMG_2hB KPTN protein_coding retained_intron 24.1313 41.57242 17.99642 1.268173 1.224744 -1.207462 3.429027 2.797292 4.024470 0.5314080 0.7788252 0.5232000 0.16975833 0.06666667 0.2211667 0.1545000 4.059573e-05 3.120205e-05 FALSE FALSE
ENST00000598699 ENSG00000118162 HEK293_OSMI2_2hA HEK293_TMG_2hB KPTN protein_coding processed_transcript 24.1313 41.57242 17.99642 1.268173 1.224744 -1.207462 1.357668 3.223884 1.804431 0.8586063 0.9569842 -0.8337506 0.05380417 0.07840000 0.0937000 0.0153000 9.484580e-01 3.120205e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118162 E001 24.400328 0.0029950496 3.037441e-02 7.270079e-02 19 47475150 47475192 43 - 1.154 1.358 0.717
ENSG00000118162 E002 232.480518 0.0088084544 1.814787e-02 4.744966e-02 19 47475193 47475544 352 - 2.173 2.303 0.437
ENSG00000118162 E003 3.491586 0.0291277313 5.907945e-02 1.250452e-01 19 47476115 47476187 73 - 0.792 0.483 -1.348
ENSG00000118162 E004 246.938852 0.0002035378 2.052574e-05 1.269934e-04 19 47476532 47476714 183 - 2.200 2.323 0.412
ENSG00000118162 E005 145.282669 0.0032965683 1.334520e-02 3.672373e-02 19 47476803 47476843 41 - 1.975 2.093 0.396
ENSG00000118162 E006 201.914858 0.0002395599 7.402770e-03 2.226614e-02 19 47476844 47476938 95 - 2.143 2.229 0.287
ENSG00000118162 E007 142.317182 0.0008955662 3.443685e-01 4.884555e-01 19 47477706 47477720 15 - 2.028 2.068 0.134
ENSG00000118162 E008 207.867340 0.0005125090 7.295626e-01 8.217306e-01 19 47477721 47477781 61 - 2.213 2.227 0.048
ENSG00000118162 E009 186.355808 0.0002327978 3.876114e-01 5.317525e-01 19 47479863 47479940 78 - 2.197 2.174 -0.075
ENSG00000118162 E010 218.906393 0.0039348269 3.437984e-01 4.878586e-01 19 47480298 47480407 110 - 2.276 2.244 -0.107
ENSG00000118162 E011 19.594302 0.0037353129 1.282949e-20 8.828580e-19 19 47480557 47480691 135 - 1.679 0.931 -2.633
ENSG00000118162 E012 15.242364 0.0013731545 2.924570e-09 3.977394e-08 19 47480692 47480722 31 - 1.466 0.949 -1.840
ENSG00000118162 E013 14.999149 0.0026832268 9.159679e-10 1.367973e-08 19 47480723 47480759 37 - 1.475 0.931 -1.937
ENSG00000118162 E014 107.450873 0.0003705947 3.279393e-01 4.714171e-01 19 47480760 47480763 4 - 1.970 1.935 -0.119
ENSG00000118162 E015 176.363807 0.0002487307 8.349091e-02 1.650176e-01 19 47480764 47480826 63 - 2.194 2.144 -0.166
ENSG00000118162 E016 122.579452 0.0002600596 2.165380e-01 3.462303e-01 19 47480827 47480833 7 - 2.032 1.990 -0.142
ENSG00000118162 E017 203.604252 0.0002446506 3.058027e-01 4.479426e-01 19 47480958 47481033 76 - 2.239 2.213 -0.087
ENSG00000118162 E018 6.166646 0.0027390376 1.099158e-05 7.233798e-05 19 47481579 47481634 56 - 1.137 0.595 -2.112
ENSG00000118162 E019 11.542988 0.0254297131 2.079413e-01 3.360213e-01 19 47483126 47483160 35 - 1.136 0.987 -0.542
ENSG00000118162 E020 187.977049 0.0031805626 8.963070e-01 9.377205e-01 19 47483161 47483215 55 - 2.186 2.186 0.000
ENSG00000118162 E021 209.991168 0.0002482826 7.390866e-01 8.288050e-01 19 47483295 47483379 85 - 2.235 2.229 -0.020
ENSG00000118162 E022 181.300188 0.0002048018 6.454402e-01 7.575441e-01 19 47483502 47483584 83 - 2.176 2.165 -0.035
ENSG00000118162 E023 8.575162 0.0456722901 1.741539e-01 2.935653e-01 19 47483829 47483934 106 - 1.057 0.856 -0.753
ENSG00000118162 E024 149.333280 0.0008492092 9.171113e-01 9.516203e-01 19 47483935 47484013 79 - 2.081 2.081 0.001
ENSG00000118162 E025 104.452193 0.0024867917 7.231177e-01 8.170265e-01 19 47484014 47484085 72 - 1.913 1.934 0.071
ENSG00000118162 E026 64.849179 0.0010522620 4.722974e-01 6.113374e-01 19 47484086 47484177 92 - 1.689 1.732 0.145
ENSG00000118162 E027 4.101683 0.0606250068 5.475306e-01 6.775757e-01 19 47484178 47484219 42 - 0.703 0.600 -0.439
ENSG00000118162 E028 1.700514 0.0949937957 9.008891e-01 9.407856e-01 19 47484220 47484234 15 - 0.334 0.364 0.182
ENSG00000118162 E029 1.291021 0.0117325041 7.843526e-01 8.616799e-01 19 47484235 47484265 31 - 0.333 0.283 -0.328