ENSG00000118007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000383202 ENSG00000118007 HEK293_OSMI2_2hA HEK293_TMG_2hB STAG1 protein_coding protein_coding 12.52916 3.034361 21.44746 0.06440596 0.5859867 2.817268 7.5317660 2.43898964 12.911755 0.06009834 0.62401600 2.3995434 0.70517083 0.80366667 0.60200000 -0.20166667 3.110578e-04 7.111095e-20 FALSE TRUE
ENST00000480733 ENSG00000118007 HEK293_OSMI2_2hA HEK293_TMG_2hB STAG1 protein_coding protein_coding 12.52916 3.034361 21.44746 0.06440596 0.5859867 2.817268 0.2714886 0.22057108 0.259739 0.08600888 0.08621258 0.2263526 0.03220417 0.07176667 0.01206667 -0.05970000 3.735878e-02 7.111095e-20 FALSE TRUE
MSTRG.23761.5 ENSG00000118007 HEK293_OSMI2_2hA HEK293_TMG_2hB STAG1 protein_coding   12.52916 3.034361 21.44746 0.06440596 0.5859867 2.817268 0.8292739 0.04085186 1.773467 0.04085186 0.21491516 5.1322403 0.04193333 0.01403333 0.08256667 0.06853333 8.131435e-03 7.111095e-20 FALSE TRUE
MSTRG.23761.7 ENSG00000118007 HEK293_OSMI2_2hA HEK293_TMG_2hB STAG1 protein_coding   12.52916 3.034361 21.44746 0.06440596 0.5859867 2.817268 3.0813670 0.00000000 5.418912 0.00000000 0.36160090 9.0845193 0.13899583 0.00000000 0.25220000 0.25220000 7.111095e-20 7.111095e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000118007 E001 200.6122821 0.0452075190 4.212290e-05 2.415271e-04 3 136336236 136337156 921 - 2.040 2.528 1.628
ENSG00000118007 E002 62.4319169 0.0003982261 1.197512e-07 1.198822e-06 3 136337157 136337387 231 - 1.587 1.917 1.115
ENSG00000118007 E003 143.4091853 0.0015373031 8.872855e-15 2.940241e-13 3 136337388 136337947 560 - 1.936 2.284 1.164
ENSG00000118007 E004 86.1425581 0.0003251388 1.940351e-03 7.041484e-03 3 136337948 136338094 147 - 1.756 1.952 0.663
ENSG00000118007 E005 69.6995637 0.0003642349 1.028702e-01 1.948533e-01 3 136338095 136338169 75 - 1.679 1.815 0.461
ENSG00000118007 E006 83.2849692 0.0060614112 1.960813e-01 3.213243e-01 3 136338170 136338277 108 - 1.757 1.883 0.424
ENSG00000118007 E007 90.0712794 0.0018908240 3.624408e-01 5.068527e-01 3 136338370 136338450 81 - 1.795 1.889 0.318
ENSG00000118007 E008 105.6664432 0.0003138143 5.618032e-01 6.895270e-01 3 136340491 136340605 115 - 1.867 1.939 0.245
ENSG00000118007 E009 104.6793981 0.0002550843 9.953874e-01 1.000000e+00 3 136341441 136341551 111 - 1.867 1.913 0.155
ENSG00000118007 E010 129.1277663 0.0011026469 4.497213e-01 5.909166e-01 3 136343832 136344006 175 - 1.951 2.029 0.265
ENSG00000118007 E011 0.7814233 0.1266024500 6.732436e-01 7.789812e-01 3 136348789 136349157 369 - 0.173 0.272 0.832
ENSG00000118007 E012 129.9903430 0.0077634305 5.242353e-01 6.578380e-01 3 136349158 136349363 206 - 1.951 2.034 0.279
ENSG00000118007 E013 98.7037037 0.0003104690 1.376760e-01 2.448445e-01 3 136357720 136357848 129 - 1.851 1.821 -0.103
ENSG00000118007 E014 80.2729651 0.0003250942 4.157873e-01 5.591339e-01 3 136359148 136359296 149 - 1.759 1.759 0.000
ENSG00000118007 E015 54.9365973 0.0005146811 7.182456e-01 8.134190e-01 3 136363366 136363467 102 - 1.592 1.612 0.071
ENSG00000118007 E016 69.6930831 0.0009750338 2.171838e-01 3.469969e-01 3 136366943 136367082 140 - 1.703 1.673 -0.105
ENSG00000118007 E017 85.2217064 0.0004106255 2.813562e-03 9.713896e-03 3 136369108 136369282 175 - 1.801 1.672 -0.436
ENSG00000118007 E018 68.2778051 0.0045401756 1.538394e-03 5.761016e-03 3 136377660 136377752 93 - 1.713 1.521 -0.655
ENSG00000118007 E019 64.1571679 0.0018475793 4.459361e-02 9.945055e-02 3 136398749 136398829 81 - 1.676 1.584 -0.313
ENSG00000118007 E020 0.1515154 0.0421847372 8.672349e-01   3 136417558 136417884 327 - 0.050 0.001 -5.346
ENSG00000118007 E021 71.5551200 0.0004071103 5.867934e-02 1.243707e-01 3 136417885 136417972 88 - 1.719 1.648 -0.241
ENSG00000118007 E022 65.5391954 0.0004456687 3.636306e-02 8.427375e-02 3 136421093 136421163 71 - 1.684 1.594 -0.308
ENSG00000118007 E023 92.3873377 0.0003790280 9.759653e-04 3.877642e-03 3 136422410 136422613 204 - 1.837 1.696 -0.476
ENSG00000118007 E024 61.4211595 0.0004294702 8.339760e-02 1.648865e-01 3 136422768 136422857 90 - 1.653 1.584 -0.237
ENSG00000118007 E025 30.5273580 0.0007430448 1.337302e-01 2.393352e-01 3 136422952 136422956 5 - 1.361 1.264 -0.337
ENSG00000118007 E026 66.5704156 0.0003634723 7.379733e-03 2.220460e-02 3 136422957 136423044 88 - 1.695 1.564 -0.446
ENSG00000118007 E027 67.1756595 0.0003976708 1.981999e-03 7.170648e-03 3 136433556 136433659 104 - 1.703 1.543 -0.547
ENSG00000118007 E028 81.1739681 0.0003139350 1.046916e-04 5.436668e-04 3 136443287 136443404 118 - 1.788 1.593 -0.659
ENSG00000118007 E029 92.0940927 0.0003408496 6.340430e-08 6.691040e-07 3 136452033 136452147 115 - 1.850 1.564 -0.972
ENSG00000118007 E030 71.5772097 0.0004582791 5.447575e-06 3.845680e-05 3 136464881 136464988 108 - 1.740 1.472 -0.914
ENSG00000118007 E031 52.2392744 0.0004821005 1.714877e-03 6.328714e-03 3 136472413 136472492 80 - 1.600 1.404 -0.673
ENSG00000118007 E032 62.0163160 0.0004530061 5.534899e-03 1.737844e-02 3 136473539 136473637 99 - 1.666 1.520 -0.497
ENSG00000118007 E033 74.1319115 0.0003737276 2.851716e-05 1.705224e-04 3 136477289 136477412 124 - 1.752 1.520 -0.788
ENSG00000118007 E034 1.9520526 0.0075307553 1.122524e-01 2.088331e-01 3 136499766 136500222 457 - 0.322 0.650 1.661
ENSG00000118007 E035 69.8904989 0.0003348440 4.864257e-06 3.473628e-05 3 136500223 136500296 74 - 1.732 1.459 -0.929
ENSG00000118007 E036 88.2403340 0.0002996695 1.009957e-06 8.367953e-06 3 136502628 136502779 152 - 1.829 1.574 -0.865
ENSG00000118007 E037 2.9087082 0.0095423013 2.883514e-04 1.332503e-03 3 136518043 136518247 205 - 0.322 0.945 2.832
ENSG00000118007 E038 5.7435349 0.0443669926 8.036004e-05 4.296308e-04 3 136518248 136518415 168 - 0.520 1.175 2.593
ENSG00000118007 E039 91.5015544 0.0046851147 1.935023e-05 1.204483e-04 3 136521213 136521417 205 - 1.845 1.593 -0.855
ENSG00000118007 E040 57.0298546 0.0013952906 2.356643e-04 1.115422e-03 3 136542119 136542195 77 - 1.642 1.403 -0.816
ENSG00000118007 E041 57.3268694 0.0023984107 5.952641e-04 2.515941e-03 3 136568765 136568861 97 - 1.642 1.418 -0.764
ENSG00000118007 E042 1.5585803 0.1348871187 5.977589e-01 7.194777e-01 3 136586802 136586926 125 - 0.296 0.438 0.833
ENSG00000118007 E043 7.5190229 0.0023150976 1.428463e-17 6.876719e-16 3 136591445 136591549 105 - 0.412 1.446 4.086
ENSG00000118007 E044 93.9878044 0.0024428281 7.121508e-01 8.089819e-01 3 136604309 136604473 165 - 1.817 1.884 0.224
ENSG00000118007 E045 67.7974924 0.0023096921 5.883615e-02 1.246353e-01 3 136623146 136623248 103 - 1.662 1.820 0.537
ENSG00000118007 E046 56.1957009 0.0003950060 6.381380e-02 1.330406e-01 3 136630870 136630981 112 - 1.581 1.739 0.539
ENSG00000118007 E047 0.0000000       3 136671637 136671669 33 -      
ENSG00000118007 E048 36.1771316 0.0009526570 3.469139e-01 4.910622e-01 3 136752195 136752403 209 - 1.403 1.520 0.406