ENSG00000117906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394885 ENSG00000117906 HEK293_OSMI2_2hA HEK293_TMG_2hB RCN2 protein_coding protein_coding 83.51967 20.21089 145.4488 2.694878 0.9463567 2.846692 6.226248 2.816926 19.5797019 1.408499 0.4566609 2.792790 0.10169167 0.1605333 0.134600000 -0.02593333 9.484580e-01 6.903832e-12 FALSE TRUE
MSTRG.11274.2 ENSG00000117906 HEK293_OSMI2_2hA HEK293_TMG_2hB RCN2 protein_coding   83.51967 20.21089 145.4488 2.694878 0.9463567 2.846692 68.364612 14.263365 119.7223552 1.635936 0.6972660 3.068416 0.78522083 0.7090333 0.823133333 0.11410000 5.582726e-06 6.903832e-12 FALSE TRUE
MSTRG.11274.8 ENSG00000117906 HEK293_OSMI2_2hA HEK293_TMG_2hB RCN2 protein_coding   83.51967 20.21089 145.4488 2.694878 0.9463567 2.846692 5.707176 2.356937 0.2115281 2.356937 0.2115281 -3.417459 0.07156667 0.0936000 0.001433333 -0.09216667 7.729996e-01 6.903832e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117906 E001 1.613738 0.0900977949 1.098530e-01 2.053462e-01 15 76931661 76931661 1 + 0.410 0.000 -10.802
ENSG00000117906 E002 24.341565 0.0007759172 1.382949e-02 3.783930e-02 15 76931662 76931737 76 + 1.334 1.133 -0.709
ENSG00000117906 E003 19.743291 0.0010195399 1.041007e-01 1.967514e-01 15 76931738 76931742 5 + 1.238 1.109 -0.459
ENSG00000117906 E004 28.653494 0.0007116355 1.779433e-03 6.534246e-03 15 76931743 76931748 6 + 1.408 1.156 -0.882
ENSG00000117906 E005 35.874917 0.0014276943 2.973325e-05 1.771066e-04 15 76931749 76931754 6 + 1.511 1.178 -1.159
ENSG00000117906 E006 236.387872 0.0118939614 8.327782e-18 4.137617e-16 15 76931755 76931870 116 + 2.335 1.755 -1.943
ENSG00000117906 E007 331.903679 0.0075877368 7.100469e-12 1.515052e-10 15 76931871 76931985 115 + 2.463 2.129 -1.115
ENSG00000117906 E008 1.629430 0.0090959150 4.332848e-01 5.756917e-01 15 76932323 76932360 38 + 0.386 0.241 -0.949
ENSG00000117906 E009 194.051027 0.0075622908 1.829170e-06 1.435147e-05 15 76932361 76932364 4 + 2.221 1.976 -0.822
ENSG00000117906 E010 575.337504 0.0003566952 7.390557e-13 1.851764e-11 15 76932365 76932466 102 + 2.675 2.563 -0.373
ENSG00000117906 E011 985.938317 0.0001071889 3.960644e-05 2.285090e-04 15 76935526 76935722 197 + 2.893 2.876 -0.054
ENSG00000117906 E012 1.726440 0.0084797340 1.426473e-01 2.516399e-01 15 76938726 76938815 90 + 0.301 0.598 1.566
ENSG00000117906 E013 1.638995 0.0502288142 9.397816e-02 1.813466e-01 15 76941401 76941636 236 + 0.411 0.000 -12.310
ENSG00000117906 E014 15.567875 0.0095482849 2.329344e-01 3.659129e-01 15 76941637 76941690 54 + 1.085 1.255 0.607
ENSG00000117906 E015 16.395043 0.0014183336 1.362074e-01 2.427728e-01 15 76941691 76943491 1801 + 1.105 1.290 0.659
ENSG00000117906 E016 7.201118 0.0300604405 6.699149e-02 1.383704e-01 15 76943492 76943757 266 + 0.747 1.054 1.173
ENSG00000117906 E017 788.987734 0.0001930512 4.481997e-02 9.987308e-02 15 76943758 76943871 114 + 2.792 2.802 0.033
ENSG00000117906 E018 845.196536 0.0001482286 3.583968e-01 5.027895e-01 15 76947421 76947517 97 + 2.818 2.846 0.094
ENSG00000117906 E019 23.999781 0.0101600153 8.023525e-01 8.740765e-01 15 76947518 76948409 892 + 1.295 1.306 0.039
ENSG00000117906 E020 966.173019 0.0001154544 1.319977e-01 2.368921e-01 15 76948410 76948552 143 + 2.869 2.932 0.212
ENSG00000117906 E021 16.958906 0.0132897373 3.097309e-01 4.520686e-01 15 76948553 76948796 244 + 1.124 1.273 0.528
ENSG00000117906 E022 9.406144 0.0017506078 6.737318e-01 7.793404e-01 15 76948797 76948918 122 + 0.903 0.995 0.344
ENSG00000117906 E023 1654.868978 0.0033854344 9.422960e-19 5.225854e-17 15 76949070 76954393 5324 + 3.057 3.299 0.805