ENSG00000117868

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251527 ENSG00000117868 HEK293_OSMI2_2hA HEK293_TMG_2hB ESYT2 protein_coding protein_coding 22.61339 10.35786 31.64532 1.514232 0.4174158 1.61033 6.620568 6.005467 9.573766 3.2968067 3.3835649 0.6719160 0.3843875 0.5478667 0.30143333 -0.2464333 0.788524156 0.001532042 FALSE TRUE
ENST00000275418 ENSG00000117868 HEK293_OSMI2_2hA HEK293_TMG_2hB ESYT2 protein_coding protein_coding 22.61339 10.35786 31.64532 1.514232 0.4174158 1.61033 2.226940 1.803377 2.438883 0.1105825 0.2957344 0.4334451 0.1153667 0.1788333 0.07703333 -0.1018000 0.001532042 0.001532042 FALSE TRUE
ENST00000652148 ENSG00000117868 HEK293_OSMI2_2hA HEK293_TMG_2hB ESYT2 protein_coding protein_coding 22.61339 10.35786 31.64532 1.514232 0.4174158 1.61033 12.743592 2.196120 18.294480 2.1961201 4.0968344 3.0526136 0.4515583 0.2353000 0.57956667 0.3442667 0.152323899 0.001532042 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117868 E001 0.4417591 0.0324509815 1.491493e-01 2.605120e-01 7 158730995 158730996 2 - 0.073 0.332 2.643
ENSG00000117868 E002 1.0672988 0.0146138006 1.429104e-02 3.888930e-02 7 158730997 158730997 1 - 0.136 0.588 2.965
ENSG00000117868 E003 1125.9531748 0.0031800677 1.112226e-16 4.752094e-15 7 158730998 158733612 2615 - 2.925 3.166 0.801
ENSG00000117868 E004 383.1875124 0.0002430455 2.104641e-21 1.581587e-19 7 158733613 158734252 640 - 2.466 2.694 0.760
ENSG00000117868 E005 120.5468668 0.0002963485 1.444768e-01 2.541147e-01 7 158734422 158734471 50 - 2.014 2.108 0.316
ENSG00000117868 E006 176.0476790 0.0002357679 1.109377e-03 4.334526e-03 7 158735503 158735608 106 - 2.161 2.298 0.456
ENSG00000117868 E007 176.5930198 0.0002170666 2.445478e-04 1.152459e-03 7 158737048 158737179 132 - 2.159 2.306 0.493
ENSG00000117868 E008 169.3858482 0.0010841855 2.480439e-01 3.836233e-01 7 158739023 158739121 99 - 2.165 2.244 0.265
ENSG00000117868 E009 389.9752394 0.0020665149 4.278507e-01 5.706734e-01 7 158741523 158741896 374 - 2.543 2.559 0.052
ENSG00000117868 E010 255.5025412 0.0004224249 2.475166e-03 8.689203e-03 7 158743529 158743678 150 - 2.375 2.337 -0.126
ENSG00000117868 E011 3.3098687 0.1367112266 5.589347e-02 1.195035e-01 7 158743679 158744217 539 - 0.423 0.842 1.851
ENSG00000117868 E012 238.6378215 0.0001689822 3.977100e-03 1.307845e-02 7 158748194 158748280 87 - 2.345 2.313 -0.108
ENSG00000117868 E013 230.8063690 0.0001902268 1.136184e-02 3.203075e-02 7 158749649 158749723 75 - 2.328 2.303 -0.083
ENSG00000117868 E014 21.8908403 0.0083519453 1.098813e-03 4.299813e-03 7 158752781 158752843 63 - 1.201 1.515 1.091
ENSG00000117868 E015 249.4024537 0.0001896101 1.035392e-03 4.080888e-03 7 158759486 158759581 96 - 2.366 2.325 -0.140
ENSG00000117868 E016 232.9941373 0.0001756684 3.828324e-03 1.265997e-02 7 158760058 158760147 90 - 2.335 2.301 -0.112
ENSG00000117868 E017 183.6817179 0.0007938419 8.635311e-07 7.272756e-06 7 158761496 158761544 49 - 2.252 2.130 -0.408
ENSG00000117868 E018 216.2778510 0.0002880924 2.540082e-08 2.901088e-07 7 158763083 158763165 83 - 2.322 2.204 -0.396
ENSG00000117868 E019 277.5296618 0.0001761674 2.570892e-11 5.009750e-10 7 158764677 158764853 177 - 2.432 2.306 -0.418
ENSG00000117868 E020 188.1465000 0.0053268312 1.424680e-03 5.388867e-03 7 158767654 158767774 121 - 2.261 2.143 -0.396
ENSG00000117868 E021 110.9220694 0.0063026969 4.127420e-02 9.338342e-02 7 158773341 158773366 26 - 2.025 1.945 -0.270
ENSG00000117868 E022 128.2426050 0.0037296778 3.149384e-03 1.070554e-02 7 158773367 158773396 30 - 2.093 1.993 -0.337
ENSG00000117868 E023 163.4170194 0.0006202437 4.212280e-06 3.047328e-05 7 158788004 158788093 90 - 2.202 2.088 -0.383
ENSG00000117868 E024 138.2491575 0.0002722056 6.154484e-07 5.349370e-06 7 158788345 158788417 73 - 2.135 2.000 -0.453
ENSG00000117868 E025 88.6009957 0.0028160624 1.847372e-04 8.981128e-04 7 158793650 158793673 24 - 1.947 1.795 -0.511
ENSG00000117868 E026 113.3712715 0.0002860037 5.638026e-06 3.965941e-05 7 158793674 158793726 53 - 2.048 1.912 -0.457
ENSG00000117868 E027 118.3439499 0.0002822149 4.535666e-06 3.260981e-05 7 158797942 158798076 135 - 2.065 1.930 -0.453
ENSG00000117868 E028 48.9067541 0.0004974869 2.383371e-04 1.126364e-03 7 158799031 158799072 42 - 1.695 1.514 -0.615
ENSG00000117868 E029 1.7714796 0.0080482220 9.247758e-01 9.566286e-01 7 158827543 158827641 99 - 0.393 0.436 0.234
ENSG00000117868 E030 74.3650841 0.0003623847 8.881539e-20 5.495039e-18 7 158829089 158829628 540 - 1.919 1.448 -1.598
ENSG00000117868 E031 0.4418608 0.0268752255 4.265058e-01 5.693285e-01 7 158829821 158830253 433 - 0.191 0.001 -8.186