ENSG00000117724

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366955 ENSG00000117724 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPF protein_coding protein_coding 32.68856 20.11635 33.67193 1.569039 0.7372731 0.7428893 18.359496 4.347467 26.030091 1.0009688 0.2139490 2.5791727 0.5119000 0.2135000 0.7737333 0.5602333 1.918016e-12 9.578345e-36 FALSE TRUE
ENST00000469862 ENSG00000117724 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPF protein_coding processed_transcript 32.68856 20.11635 33.67193 1.569039 0.7372731 0.7428893 12.575504 11.995674 7.336143 1.0206940 0.6518297 -0.7086575 0.4183042 0.5970000 0.2173000 -0.3797000 1.390936e-16 9.578345e-36 FALSE FALSE
MSTRG.3049.4 ENSG00000117724 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPF protein_coding   32.68856 20.11635 33.67193 1.569039 0.7372731 0.7428893 1.356179 3.535087 0.000000 0.3200919 0.0000000 -8.4696772 0.0563625 0.1774333 0.0000000 -0.1774333 9.578345e-36 9.578345e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117724 E001 16.5872636 0.0474090120 6.167422e-07 5.358894e-06 1 214603195 214603252 58 + 1.345 0.421 -3.692
ENSG00000117724 E002 41.0443173 0.0022579359 1.309689e-14 4.237827e-13 1 214603253 214603321 69 + 1.704 1.034 -2.339
ENSG00000117724 E003 0.3299976 0.0258133809 3.622103e-02   1 214603484 214603648 165 + 0.000 0.320 11.754
ENSG00000117724 E004 89.3815497 0.0238067467 5.031736e-13 1.294821e-11 1 214613714 214613916 203 + 2.041 1.308 -2.492
ENSG00000117724 E005 96.2095541 0.0246414917 2.145552e-13 5.816664e-12 1 214614832 214615028 197 + 2.073 1.331 -2.524
ENSG00000117724 E006 0.1451727 0.0433266487 1.000000e+00   1 214615029 214615190 162 + 0.077 0.000 -8.062
ENSG00000117724 E007 57.7781461 0.0573112561 1.136140e-07 1.142454e-06 1 214618573 214618694 122 + 1.856 1.100 -2.611
ENSG00000117724 E008 48.2061227 0.0031065282 2.007499e-17 9.425394e-16 1 214619129 214619220 92 + 1.776 1.055 -2.505
ENSG00000117724 E009 114.6924077 0.0164371564 7.744170e-15 2.590236e-13 1 214620655 214620946 292 + 2.143 1.484 -2.230
ENSG00000117724 E010 117.0356308 0.0108077043 7.133518e-16 2.747913e-14 1 214622079 214622281 203 + 2.145 1.551 -2.005
ENSG00000117724 E011 82.2567428 0.0008935940 4.114139e-24 4.123869e-22 1 214629046 214629171 126 + 1.995 1.388 -2.063
ENSG00000117724 E012 74.5164759 0.0003515388 2.126069e-26 2.613740e-24 1 214630534 214630662 129 + 1.958 1.290 -2.280
ENSG00000117724 E013 76.2460006 0.0004182861 6.049513e-28 8.508256e-26 1 214632480 214632602 123 + 1.969 1.278 -2.360
ENSG00000117724 E014 83.8187422 0.0003126174 6.067762e-31 1.087530e-28 1 214637866 214638001 136 + 2.010 1.314 -2.371
ENSG00000117724 E015 639.6522338 0.0370399399 5.988244e-09 7.710561e-08 1 214639921 214641812 1892 + 2.872 2.351 -1.734
ENSG00000117724 E016 271.1959560 0.0040932933 6.450667e-19 3.633838e-17 1 214641813 214642437 625 + 2.482 2.091 -1.306
ENSG00000117724 E017 376.2523881 0.0088026481 9.898534e-10 1.469284e-08 1 214642438 214643324 887 + 2.612 2.296 -1.055
ENSG00000117724 E018 499.5788021 0.0100929788 1.283672e-06 1.041578e-05 1 214644557 214645579 1023 + 2.723 2.473 -0.831
ENSG00000117724 E019 1016.2609014 0.0021127817 5.411697e-01 6.722025e-01 1 214645580 214647400 1821 + 2.968 2.969 0.001
ENSG00000117724 E020 235.4852869 0.0005953318 5.161763e-09 6.717135e-08 1 214648675 214648827 153 + 2.289 2.423 0.448
ENSG00000117724 E021 261.3359299 0.0001926654 5.420993e-18 2.738642e-16 1 214651710 214651886 177 + 2.315 2.496 0.604
ENSG00000117724 E022 130.2562852 0.0002548090 3.225252e-12 7.283517e-11 1 214652828 214652857 30 + 2.003 2.210 0.695
ENSG00000117724 E023 189.0875917 0.0046267109 3.859382e-10 6.172633e-09 1 214652858 214652989 132 + 2.150 2.394 0.815
ENSG00000117724 E024 6.3787320 0.0026139273 7.599525e-01 8.441886e-01 1 214653485 214654419 935 + 0.822 0.845 0.087
ENSG00000117724 E025 1.6877184 0.1162329679 8.682036e-01 9.192341e-01 1 214655148 214655240 93 + 0.407 0.419 0.066
ENSG00000117724 E026 263.2668579 0.0011078874 2.704928e-25 3.028609e-23 1 214655241 214655403 163 + 2.286 2.546 0.866
ENSG00000117724 E027 537.1128950 0.0029584928 2.503152e-35 6.239667e-33 1 214656933 214657409 477 + 2.560 2.898 1.122
ENSG00000117724 E028 0.4470576 0.0218259055 7.470349e-01 8.346515e-01 1 214657410 214657410 1 + 0.143 0.189 0.482
ENSG00000117724 E029 293.2768400 0.0024866549 1.177790e-46 5.982003e-44 1 214658850 214659028 179 + 2.252 2.678 1.421
ENSG00000117724 E030 498.6046476 0.0167899083 2.802863e-15 1.001309e-13 1 214663591 214664571 981 + 2.462 2.929 1.557