ENSG00000117625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367005 ENSG00000117625 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR3 protein_coding protein_coding 11.27263 11.18017 12.42664 0.2344773 0.9041997 0.1523652 0.8088822 0.7506363 0.728795 0.2399653 0.35438530 -0.04203272 0.07100833 0.06796667 0.06260000 -0.005366667 0.899816684 0.0005056633 FALSE TRUE
ENST00000419091 ENSG00000117625 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR3 protein_coding protein_coding 11.27263 11.18017 12.42664 0.2344773 0.9041997 0.1523652 1.3116691 0.8931430 1.561543 0.3477823 0.42516562 0.79915569 0.11067917 0.07876667 0.12506667 0.046300000 0.622673219 0.0005056633 FALSE TRUE
ENST00000452621 ENSG00000117625 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR3 protein_coding protein_coding 11.27263 11.18017 12.42664 0.2344773 0.9041997 0.1523652 4.4650599 3.5758585 5.675923 0.3562308 0.06460585 0.66507601 0.39128333 0.32143333 0.46100000 0.139566667 0.113491261 0.0005056633 FALSE TRUE
ENST00000472734 ENSG00000117625 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR3 protein_coding processed_transcript 11.27263 11.18017 12.42664 0.2344773 0.9041997 0.1523652 2.2575685 4.9271470 1.290577 0.4544116 0.58134173 -1.92452597 0.20743750 0.43953333 0.09836667 -0.341166667 0.003601631 0.0005056633 FALSE FALSE
MSTRG.2994.10 ENSG00000117625 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR3 protein_coding   11.27263 11.18017 12.42664 0.2344773 0.9041997 0.1523652 0.7321278 0.4041183 1.217613 0.2140808 0.31424115 1.56774096 0.06098750 0.03593333 0.09543333 0.059500000 0.453038608 0.0005056633 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117625 E001 0.0000000       1 211257970 211258376 407 +      
ENSG00000117625 E002 0.0000000       1 211258377 211258407 31 +      
ENSG00000117625 E003 0.0000000       1 211258408 211258490 83 +      
ENSG00000117625 E004 0.3729606 0.0312938457 8.079906e-01 8.779822e-01 1 211258491 211258525 35 + 0.106 0.142 0.486
ENSG00000117625 E005 0.2214452 0.0407400913 3.536769e-01   1 211259236 211259278 43 + 0.000 0.142 10.360
ENSG00000117625 E006 2.3206556 0.0065179746 2.744607e-02 6.689707e-02 1 211259279 211259365 87 + 0.322 0.685 1.804
ENSG00000117625 E007 7.6704881 0.0033618179 1.631088e-02 4.341327e-02 1 211259366 211259387 22 + 0.775 1.057 1.070
ENSG00000117625 E008 8.0391824 0.0134307183 2.446312e-02 6.077669e-02 1 211259388 211259395 8 + 0.794 1.073 1.049
ENSG00000117625 E009 39.4715071 0.0040994806 3.399986e-02 7.976091e-02 1 211259396 211259552 157 + 1.535 1.668 0.451
ENSG00000117625 E010 33.1210927 0.0007298949 6.347965e-03 1.952817e-02 1 211259553 211259578 26 + 1.442 1.609 0.571
ENSG00000117625 E011 33.1941324 0.0007160935 1.161601e-02 3.262059e-02 1 211259579 211259605 27 + 1.451 1.605 0.527
ENSG00000117625 E012 55.7372677 0.0065517135 3.649044e-03 1.215196e-02 1 211259606 211259726 121 + 1.661 1.834 0.584
ENSG00000117625 E013 7.1366914 0.0038252305 2.248646e-01 3.562700e-01 1 211259727 211259729 3 + 0.831 0.976 0.552
ENSG00000117625 E014 0.6621601 0.0163831899 7.446575e-01 8.329041e-01 1 211259947 211259974 28 + 0.190 0.248 0.484
ENSG00000117625 E015 5.1346559 0.0033220842 1.515916e-01 2.638290e-01 1 211259975 211260107 133 + 0.686 0.877 0.764
ENSG00000117625 E016 55.1338698 0.0005030339 3.898573e-04 1.735491e-03 1 211260108 211260164 57 + 1.661 1.830 0.569
ENSG00000117625 E017 32.0405452 0.0039552117 1.284893e-22 1.098461e-20 1 211260929 211261202 274 + 1.038 1.761 2.517
ENSG00000117625 E018 0.3666179 0.0308390366 8.067151e-01 8.772128e-01 1 211267775 211267870 96 + 0.106 0.142 0.487
ENSG00000117625 E019 40.4627909 0.0006174423 1.437327e-02 3.907600e-02 1 211271232 211271309 78 + 1.679 1.547 -0.451
ENSG00000117625 E020 1.1521939 0.0598022282 5.058742e-01 6.415909e-01 1 211271310 211271527 218 + 0.376 0.249 -0.833
ENSG00000117625 E021 5.9654669 0.0300568773 8.339310e-03 2.464022e-02 1 211271528 211271874 347 + 0.980 0.569 -1.657
ENSG00000117625 E022 38.8859130 0.0006695578 7.643349e-02 1.537955e-01 1 211274210 211274262 53 + 1.648 1.552 -0.329
ENSG00000117625 E023 62.9057380 0.0025478200 6.154506e-03 1.901764e-02 1 211276257 211276418 162 + 1.865 1.732 -0.450
ENSG00000117625 E024 50.4679531 0.0005059159 5.523391e-04 2.355620e-03 1 211278117 211278181 65 + 1.783 1.613 -0.578
ENSG00000117625 E025 59.9927208 0.0004325485 2.402442e-03 8.468581e-03 1 211278182 211278241 60 + 1.844 1.708 -0.460
ENSG00000117625 E026 62.4580115 0.0008521258 1.231959e-03 4.748932e-03 1 211279238 211279316 79 + 1.864 1.717 -0.495
ENSG00000117625 E027 78.9867364 0.0007105306 5.962543e-03 1.850870e-02 1 211289178 211289331 154 + 1.951 1.842 -0.368
ENSG00000117625 E028 64.1816643 0.0003789523 2.816605e-02 6.834069e-02 1 211289332 211289396 65 + 1.854 1.760 -0.317
ENSG00000117625 E029 0.4375944 0.0253180330 1.504510e-01 2.622970e-01 1 211291524 211291599 76 + 0.261 0.000 -12.210
ENSG00000117625 E030 57.5578937 0.0007571044 4.722514e-01 6.112993e-01 1 211295676 211295753 78 + 1.777 1.746 -0.108
ENSG00000117625 E031 7.5421068 0.1935741307 1.440980e-02 3.915565e-02 1 211301461 211304010 2550 + 1.101 0.536 -2.253
ENSG00000117625 E032 0.4513240 0.2149197550 8.060084e-01 8.766894e-01 1 211304011 211304082 72 + 0.191 0.140 -0.538
ENSG00000117625 E033 50.2349644 0.0006118344 6.890796e-01 7.910419e-01 1 211304083 211304140 58 + 1.715 1.698 -0.059
ENSG00000117625 E034 4.3546773 0.0037863544 2.560049e-05 1.548319e-04 1 211312237 211312354 118 + 0.926 0.248 -3.271
ENSG00000117625 E035 14.3495983 0.0107810237 1.686805e-03 6.240799e-03 1 211312355 211312487 133 + 1.307 0.977 -1.184
ENSG00000117625 E036 70.9778745 0.0004156221 2.645405e-01 4.025054e-01 1 211312720 211312835 116 + 1.837 1.885 0.162
ENSG00000117625 E037 75.0115635 0.0037050695 7.817290e-02 1.565284e-01 1 211312836 211312961 126 + 1.842 1.932 0.301
ENSG00000117625 E038 36.8815616 0.0099216230 2.989732e-06 2.237745e-05 1 211312962 211313298 337 + 1.387 1.740 1.205
ENSG00000117625 E039 269.6653490 0.0028797510 1.528453e-01 2.655171e-01 1 211313424 211316385 2962 + 2.450 2.412 -0.124