ENSG00000117597

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000491415 ENSG00000117597 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP25 protein_coding protein_coding 12.46484 6.90449 18.80222 0.84525 0.8363692 1.443975 3.632513 2.634051 5.7280425 0.1410816 0.1101883 1.117809 0.32793750 0.3930333 0.3063000 -0.08673333 4.351620e-01 6.484538e-11 FALSE TRUE
MSTRG.2976.1 ENSG00000117597 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP25 protein_coding   12.46484 6.90449 18.80222 0.84525 0.8363692 1.443975 0.793394 1.313594 0.5925092 0.2719368 0.1181517 -1.135405 0.08651667 0.1863333 0.0311000 -0.15523333 6.484538e-11 6.484538e-11 FALSE TRUE
MSTRG.2976.4 ENSG00000117597 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP25 protein_coding   12.46484 6.90449 18.80222 0.84525 0.8363692 1.443975 7.076450 2.592893 10.9917091 0.4748265 0.8279467 2.079540 0.51331667 0.3714333 0.5830333 0.21160000 9.256053e-04 6.484538e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117597 E001 0.7675920 0.0160761291 8.001811e-01 8.726232e-01 1 209827967 209827969 3 + 0.229 0.282 0.391
ENSG00000117597 E002 0.9127647 0.0153902297 9.540497e-01 9.752109e-01 1 209827970 209827971 2 + 0.285 0.282 -0.024
ENSG00000117597 E003 3.8655975 0.0041777593 2.636857e-01 4.015907e-01 1 209827972 209827985 14 + 0.733 0.573 -0.686
ENSG00000117597 E004 5.4961734 0.0029097216 1.845132e-02 4.812284e-02 1 209827986 209827987 2 + 0.901 0.573 -1.345
ENSG00000117597 E005 94.7022726 0.0003092739 2.136020e-08 2.476969e-07 1 209827988 209828170 183 + 2.038 1.833 -0.688
ENSG00000117597 E006 74.8055826 0.0067512720 7.631759e-04 3.125881e-03 1 209830108 209830147 40 + 1.931 1.745 -0.628
ENSG00000117597 E007 45.1271153 0.0143339773 5.336246e-03 1.684640e-02 1 209830803 209830806 4 + 1.722 1.502 -0.750
ENSG00000117597 E008 140.5927916 0.0017574025 1.632654e-09 2.326623e-08 1 209830807 209831043 237 + 2.209 1.994 -0.718
ENSG00000117597 E009 104.3189780 0.0094388847 7.436481e-01 8.322468e-01 1 209833185 209833358 174 + 2.015 2.006 -0.030
ENSG00000117597 E010 74.1828390 0.0084387040 6.911716e-01 7.926989e-01 1 209835075 209835163 89 + 1.871 1.857 -0.046
ENSG00000117597 E011 180.1061442 0.0002190771 1.662011e-01 2.832598e-01 1 209836801 209837211 411 + 2.259 2.237 -0.073
ENSG00000117597 E012 0.1472490 0.0433909965 1.000000e+00   1 209838805 209838908 104 + 0.091 0.000 -8.263
ENSG00000117597 E013 141.5864009 0.0037510424 3.533999e-01 4.976441e-01 1 209838909 209839128 220 + 2.155 2.133 -0.071
ENSG00000117597 E014 135.0003724 0.0002448400 7.531099e-01 8.391477e-01 1 209840853 209841055 203 + 2.116 2.141 0.083
ENSG00000117597 E015 114.6038203 0.0003966873 2.649649e-01 4.029735e-01 1 209842265 209842447 183 + 2.035 2.088 0.176
ENSG00000117597 E016 2.2594516 0.0083529096 6.649755e-02 1.375527e-01 1 209842448 209842582 135 + 0.604 0.282 -1.724
ENSG00000117597 E017 79.2286862 0.0005280259 5.489555e-01 6.787582e-01 1 209842583 209842695 113 + 1.884 1.924 0.134
ENSG00000117597 E018 6.6357850 0.0024583694 4.912872e-04 2.127332e-03 1 209842696 209843450 755 + 1.002 0.516 -1.986
ENSG00000117597 E019 137.3276733 0.0002457782 4.634371e-01 6.032401e-01 1 209843451 209843696 246 + 2.120 2.158 0.126
ENSG00000117597 E020 2.6970460 0.0058628400 2.393809e-02 5.967576e-02 1 209843697 209844632 936 + 0.673 0.282 -2.023
ENSG00000117597 E021 1.6232010 0.0084784226 5.170143e-02 1.121841e-01 1 209845215 209845304 90 + 0.521 0.163 -2.345
ENSG00000117597 E022 107.8406277 0.0026846515 7.662478e-03 2.293365e-02 1 209851204 209851359 156 + 1.978 2.106 0.428
ENSG00000117597 E023 364.7340108 0.0020703705 7.283737e-01 8.208503e-01 1 209851360 209854293 2934 + 2.545 2.565 0.066
ENSG00000117597 E024 413.3916022 0.0024600562 6.294914e-11 1.147568e-09 1 209854294 209857565 3272 + 2.531 2.708 0.588