ENSG00000117593

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000648458 ENSG00000117593 HEK293_OSMI2_2hA HEK293_TMG_2hB DARS2 protein_coding protein_coding 41.91922 35.99294 54.56052 2.638748 0.9994824 0.6000071 3.683427 0.9830089 6.239488 0.1295677 0.3498011 2.6538595 0.07595000 0.0271000 0.11466667 0.08756667 4.402352e-14 4.402352e-14 FALSE  
ENST00000648807 ENSG00000117593 HEK293_OSMI2_2hA HEK293_TMG_2hB DARS2 protein_coding protein_coding 41.91922 35.99294 54.56052 2.638748 0.9994824 0.6000071 4.683091 3.6227095 6.402599 0.2582156 0.7629686 0.8198631 0.10965833 0.1010333 0.11753333 0.01650000 7.345870e-01 4.402352e-14 FALSE  
ENST00000649106 ENSG00000117593 HEK293_OSMI2_2hA HEK293_TMG_2hB DARS2 protein_coding protein_coding 41.91922 35.99294 54.56052 2.638748 0.9994824 0.6000071 2.357167 3.4790042 2.799257 0.2464115 0.3784834 -0.3126269 0.07207917 0.0967000 0.05156667 -0.04513333 1.417060e-02 4.402352e-14 FALSE  
ENST00000649689 ENSG00000117593 HEK293_OSMI2_2hA HEK293_TMG_2hB DARS2 protein_coding protein_coding 41.91922 35.99294 54.56052 2.638748 0.9994824 0.6000071 29.251656 26.7146632 36.195003 1.9040980 1.8301909 0.4380173 0.69524583 0.7425333 0.66280000 -0.07973333 8.640427e-02 4.402352e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117593 E001 18.836675 0.0307604502 5.117846e-03 1.625035e-02 1 173824653 173824660 8 + 1.422 1.114 -1.082
ENSG00000117593 E002 18.936796 0.0415605158 5.283274e-03 1.670311e-02 1 173824661 173824662 2 + 1.431 1.099 -1.166
ENSG00000117593 E003 35.378802 0.0005750076 9.647722e-05 5.054988e-04 1 173824663 173824672 10 + 1.655 1.432 -0.762
ENSG00000117593 E004 48.013367 0.0018862879 7.891510e-04 3.220505e-03 1 173824673 173824683 11 + 1.769 1.598 -0.581
ENSG00000117593 E005 88.681989 0.0010022713 4.754866e-06 3.402308e-05 1 173824684 173824707 24 + 2.029 1.854 -0.587
ENSG00000117593 E006 91.603724 0.0040333542 2.596710e-04 1.215505e-03 1 173824708 173824711 4 + 2.039 1.871 -0.563
ENSG00000117593 E007 219.285593 0.0053860191 3.492938e-05 2.042492e-04 1 173824712 173824842 131 + 2.415 2.244 -0.570
ENSG00000117593 E008 132.454936 0.0083593211 1.699468e-03 6.282007e-03 1 173824843 173824846 4 + 2.194 2.030 -0.547
ENSG00000117593 E009 272.259466 0.0068223648 9.300715e-06 6.226809e-05 1 173824847 173824959 113 + 2.517 2.320 -0.657
ENSG00000117593 E010 622.672724 0.0013124333 3.583159e-13 9.421494e-12 1 173824960 173825356 397 + 2.859 2.708 -0.505
ENSG00000117593 E011 375.319548 0.0001375542 6.536248e-09 8.343031e-08 1 173826687 173826786 100 + 2.619 2.522 -0.323
ENSG00000117593 E012 8.658522 0.0024476559 1.075568e-01 2.019296e-01 1 173826787 173828332 1546 + 0.883 1.070 0.696
ENSG00000117593 E013 287.848933 0.0003203152 1.917170e-06 1.497123e-05 1 173828333 173828399 67 + 2.503 2.408 -0.316
ENSG00000117593 E014 344.285544 0.0005211503 3.956757e-03 1.302127e-02 1 173830660 173830761 102 + 2.563 2.511 -0.172
ENSG00000117593 E015 1.291979 0.0420154857 2.880678e-01 4.286163e-01 1 173830762 173831027 266 + 0.262 0.464 1.203
ENSG00000117593 E016 288.020991 0.0026037860 9.625067e-02 1.847494e-01 1 173831535 173831630 96 + 2.482 2.437 -0.150
ENSG00000117593 E017 201.428392 0.0003204324 2.557256e-01 3.926445e-01 1 173833376 173833427 52 + 2.316 2.297 -0.061
ENSG00000117593 E018 218.078203 0.0002199716 6.956169e-01 7.961763e-01 1 173833428 173833499 72 + 2.341 2.343 0.007
ENSG00000117593 E019 176.662007 0.0001905313 3.448413e-01 4.889431e-01 1 173834473 173834519 47 + 2.234 2.271 0.125
ENSG00000117593 E020 278.437856 0.0001501456 4.137898e-01 5.571952e-01 1 173836940 173837046 107 + 2.452 2.446 -0.018
ENSG00000117593 E021 298.351267 0.0007815737 7.207095e-01 8.152829e-01 1 173838190 173838259 70 + 2.477 2.480 0.010
ENSG00000117593 E022 447.180673 0.0001168337 9.844852e-01 9.943748e-01 1 173839367 173839546 180 + 2.649 2.660 0.039
ENSG00000117593 E023 328.865514 0.0004915218 1.993160e-01 3.253811e-01 1 173840866 173840973 108 + 2.501 2.539 0.127
ENSG00000117593 E024 273.275745 0.0001549731 2.054620e-02 5.264360e-02 1 173845229 173845291 63 + 2.411 2.473 0.206
ENSG00000117593 E025 386.477729 0.0011747789 5.139482e-04 2.211505e-03 1 173850327 173850479 153 + 2.544 2.637 0.310
ENSG00000117593 E026 7.698908 0.0320491998 1.540957e-01 2.672296e-01 1 173851836 173852014 179 + 0.833 1.050 0.815
ENSG00000117593 E027 502.892885 0.0002270140 2.254340e-10 3.740065e-09 1 173853349 173853567 219 + 2.647 2.764 0.392
ENSG00000117593 E028 2.699015 0.0377588985 1.431013e-01 2.522457e-01 1 173853568 173853794 227 + 0.425 0.684 1.210
ENSG00000117593 E029 381.579805 0.0002413762 9.155758e-05 4.822964e-04 1 173853795 173853905 111 + 2.544 2.630 0.288
ENSG00000117593 E030 4.970381 0.0032350476 8.936758e-02 1.741640e-01 1 173853906 173854646 741 + 0.662 0.897 0.941
ENSG00000117593 E031 307.570980 0.0018104253 4.170618e-07 3.747800e-06 1 173856666 173856741 76 + 2.413 2.567 0.513
ENSG00000117593 E032 13.833322 0.0014585070 4.251685e-02 9.565897e-02 1 173856742 173857517 776 + 1.245 1.069 -0.627
ENSG00000117593 E033 1244.372468 0.0027527264 1.487490e-11 3.012620e-10 1 173857518 173858808 1291 + 3.007 3.179 0.572