ENSG00000117569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370197 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding protein_coding 10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 0.1795506 0.1890655 0.2225383 0.09655622 0.2225383 0.2242247 0.03812917 0.1476667 0.01566667 -0.13200000 2.513137e-01 1.373816e-06 FALSE TRUE
ENST00000459735 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding retained_intron 10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 1.9051660 0.0000000 3.2117414 0.00000000 0.2354105 8.3316969 0.12235000 0.0000000 0.19466667 0.19466667 2.073123e-06 1.373816e-06 FALSE FALSE
ENST00000460706 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding retained_intron 10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 1.6310516 0.0000000 2.6901035 0.00000000 0.0625805 8.0768709 0.09472083 0.0000000 0.16186667 0.16186667 1.373816e-06 1.373816e-06 FALSE TRUE
ENST00000462433 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding retained_intron 10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 4.8746486 0.4508772 7.7644123 0.23146550 1.3394460 4.0762793 0.50061250 0.3234333 0.45400000 0.13056667 7.772385e-01 1.373816e-06 FALSE FALSE
ENST00000609116 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding protein_coding 10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 0.5135293 0.1950273 1.1126786 0.10602509 0.2496845 2.4530567 0.04987500 0.1616000 0.06603333 -0.09556667 6.837540e-01 1.373816e-06 FALSE TRUE
ENST00000675080 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding retained_intron 10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 0.3890846 0.1190707 0.5029135 0.06024827 0.0590116 1.9905533 0.05678333 0.1023667 0.03023333 -0.07213333 3.186899e-01 1.373816e-06 TRUE TRUE
MSTRG.1659.1 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding   10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 0.4624226 0.1327369 0.4010884 0.13273686 0.2105740 1.5260908 0.04124583 0.1218333 0.02210000 -0.09973333 1.000000e+00 1.373816e-06 TRUE TRUE
MSTRG.1659.4 ENSG00000117569 HEK293_OSMI2_2hA HEK293_TMG_2hB PTBP2 protein_coding   10.51787 1.288356 16.82854 0.114062 1.312317 3.69701 0.2151079 0.1769846 0.5265042 0.11294151 0.2663803 1.5206697 0.03597083 0.1240667 0.03340000 -0.09066667 7.316568e-01 1.373816e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117569 E001 0.2903454 0.3297893854 1.000000e+00   1 96721660 96721664 5 + 0.106 0.000 -13.375
ENSG00000117569 E002 0.2903454 0.3297893854 1.000000e+00   1 96721665 96721776 112 + 0.106 0.000 -13.347
ENSG00000117569 E003 0.1451727 0.0432107089 1.000000e+00   1 96721777 96721779 3 + 0.056 0.000 -12.352
ENSG00000117569 E004 0.5997190 0.1201253032 5.220351e-01 6.559049e-01 1 96721780 96721782 3 + 0.192 0.000 -14.355
ENSG00000117569 E005 1.0436561 0.0136637493 1.938003e-01 3.185535e-01 1 96721783 96721783 1 + 0.294 0.000 -15.160
ENSG00000117569 E006 1.4875932 0.0091951270 8.794518e-02 1.719982e-01 1 96721784 96721787 4 + 0.377 0.000 -15.674
ENSG00000117569 E007 2.4183419 0.0169577959 1.644151e-01 2.809286e-01 1 96721788 96721791 4 + 0.488 0.247 -1.439
ENSG00000117569 E008 10.0217836 0.0193239718 7.943337e-01 8.686003e-01 1 96721792 96721809 18 + 0.929 0.974 0.171
ENSG00000117569 E009 18.0490926 0.0079851568 2.786810e-01 4.183453e-01 1 96721810 96721821 12 + 1.176 1.147 -0.104
ENSG00000117569 E010 32.2316952 0.0006498572 8.881621e-04 3.572923e-03 1 96721822 96721872 51 + 1.438 1.251 -0.650
ENSG00000117569 E011 0.1451727 0.0432107089 1.000000e+00   1 96721873 96721896 24 + 0.056 0.000 -12.352
ENSG00000117569 E012 0.0000000       1 96722030 96722045 16 +      
ENSG00000117569 E013 0.0000000       1 96722046 96722107 62 +      
ENSG00000117569 E014 0.0000000       1 96722635 96722637 3 +      
ENSG00000117569 E015 0.0000000       1 96722638 96722716 79 +      
ENSG00000117569 E016 0.0000000       1 96722717 96722797 81 +      
ENSG00000117569 E017 33.0703669 0.0005973036 7.956566e-05 4.258285e-04 1 96723564 96723594 31 + 1.457 1.212 -0.854
ENSG00000117569 E018 47.1775243 0.0005063081 2.146759e-05 1.321217e-04 1 96751425 96751500 76 + 1.601 1.393 -0.712
ENSG00000117569 E019 61.7321727 0.0145031889 3.532223e-03 1.181881e-02 1 96769703 96769875 173 + 1.709 1.558 -0.515
ENSG00000117569 E020 57.3360475 0.0031846255 1.950372e-06 1.520669e-05 1 96770708 96770851 144 + 1.689 1.444 -0.837
ENSG00000117569 E021 0.1451727 0.0432107089 1.000000e+00   1 96770852 96771475 624 + 0.056 0.000 -12.352
ENSG00000117569 E022 56.8403593 0.0065000558 5.477436e-05 3.055876e-04 1 96777585 96777749 165 + 1.681 1.467 -0.731
ENSG00000117569 E023 42.7545860 0.0072308246 2.195850e-01 3.498862e-01 1 96777836 96777946 111 + 1.527 1.522 -0.017
ENSG00000117569 E024 0.1515154 0.0427398994 1.000000e+00   1 96784948 96785058 111 + 0.056 0.000 -12.353
ENSG00000117569 E025 49.1241492 0.0004907538 2.026394e-01 3.295144e-01 1 96785059 96785193 135 + 1.584 1.602 0.064
ENSG00000117569 E026 28.2814282 0.0007239083 9.132594e-01 9.490270e-01 1 96785194 96785254 61 + 1.338 1.444 0.368
ENSG00000117569 E027 4.4725740 0.0035357553 3.459033e-02 8.087868e-02 1 96804785 96804799 15 + 0.543 0.937 1.620
ENSG00000117569 E028 34.2536528 0.0013992159 9.535743e-01 9.749321e-01 1 96804800 96804939 140 + 1.418 1.520 0.352
ENSG00000117569 E029 14.6996226 0.0063137574 3.594843e-01 5.038089e-01 1 96804940 96806418 1479 + 1.056 1.250 0.692
ENSG00000117569 E030 16.6810896 0.0010967812 1.531159e-01 2.659076e-01 1 96806419 96806452 34 + 1.155 1.096 -0.211
ENSG00000117569 E031 2.9196371 0.0391185076 3.849598e-01 5.291080e-01 1 96806811 96806865 55 + 0.525 0.404 -0.615
ENSG00000117569 E032 50.6299194 0.0011057821 1.229463e-02 3.424108e-02 1 96806866 96806958 93 + 1.614 1.549 -0.221
ENSG00000117569 E033 96.7823462 0.0003006759 5.720990e-02 1.218246e-01 1 96812712 96812928 217 + 1.874 1.890 0.051
ENSG00000117569 E034 67.9347479 0.0004256823 8.928994e-01 9.355621e-01 1 96813029 96813106 78 + 1.704 1.810 0.359
ENSG00000117569 E035 21.4295735 0.0009171443 8.598547e-01 9.136177e-01 1 96813273 96813275 3 + 1.225 1.304 0.279
ENSG00000117569 E036 403.3716803 0.0131848852 6.542624e-08 6.888681e-07 1 96813276 96823738 10463 + 2.420 2.726 1.019