ENSG00000117543

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342173 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding protein_coding 48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 3.667770 2.193281 3.967918 0.2690914 0.9005273 0.8523601 0.07528750 0.06366667 0.06936667 0.005700000 0.991639304 0.001276674 FALSE TRUE
ENST00000370109 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding protein_coding 48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 9.425512 5.714821 14.138680 1.4558104 0.6940202 1.3053651 0.18521667 0.15610000 0.24066667 0.084566667 0.001276674 0.001276674 FALSE TRUE
ENST00000476507 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding processed_transcript 48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 6.817281 6.178370 8.153969 1.2982911 1.8317663 0.3997113 0.14492500 0.17546667 0.13626667 -0.039200000 0.703498053 0.001276674 FALSE TRUE
ENST00000488176 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding protein_coding 48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 4.415918 3.226456 5.372935 0.4697084 0.7370244 0.7339781 0.09367917 0.09183333 0.09050000 -0.001333333 1.000000000 0.001276674 FALSE TRUE
ENST00000492067 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding processed_transcript 48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 7.001702 8.196548 5.788263 2.9272147 0.5206071 -0.5011548 0.15394583 0.21383333 0.09870000 -0.115133333 0.001667854 0.001276674 FALSE TRUE
MSTRG.1711.11 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding   48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 6.211674 3.663344 7.850908 1.1328239 0.6274993 1.0976022 0.12420833 0.09743333 0.13393333 0.036500000 0.230928174 0.001276674 TRUE TRUE
MSTRG.1711.8 ENSG00000117543 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH5 protein_coding   48.59555 36.43425 58.91166 8.445484 3.280737 0.6931069 5.524417 3.173905 7.559322 0.7554405 0.2999713 1.2493667 0.10315833 0.08863333 0.12866667 0.040033333 0.130192829 0.001276674 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117543 E001 2.0229259 0.1586027448 7.604403e-01 8.445538e-01 1 100989623 100989652 30 - 0.465 0.515 0.247
ENSG00000117543 E002 4.0449083 0.0402112229 9.388648e-01 9.656139e-01 1 100989653 100989664 12 - 0.709 0.717 0.035
ENSG00000117543 E003 54.4036214 0.0005045813 4.737480e-06 3.390944e-05 1 100989665 100990062 398 - 1.837 1.614 -0.757
ENSG00000117543 E004 60.6125679 0.0003992062 1.759538e-01 2.959358e-01 1 100990063 100990094 32 - 1.768 1.831 0.211
ENSG00000117543 E005 180.8468691 0.0007763548 3.619222e-04 1.626453e-03 1 100990095 100990222 128 - 2.220 2.325 0.350
ENSG00000117543 E006 107.5620706 0.0030564928 1.403094e-03 5.316560e-03 1 100990223 100990223 1 - 1.974 2.118 0.483
ENSG00000117543 E007 132.1060983 0.0015068387 8.581969e-05 4.554651e-04 1 100990224 100990266 43 - 2.064 2.208 0.481
ENSG00000117543 E008 84.4741595 0.0061839597 3.005896e-02 7.207144e-02 1 100990267 100990268 2 - 1.879 2.007 0.429
ENSG00000117543 E009 181.2386585 0.0029810499 1.724348e-01 2.913678e-01 1 100990269 100990314 46 - 2.243 2.299 0.186
ENSG00000117543 E010 147.8077180 0.0040664637 5.480162e-01 6.779331e-01 1 100990315 100990332 18 - 2.167 2.196 0.099
ENSG00000117543 E011 130.2572999 0.0014820438 5.823785e-01 7.067443e-01 1 100990333 100990333 1 - 2.118 2.140 0.077
ENSG00000117543 E012 151.3912368 0.0004217892 5.824339e-02 1.236161e-01 1 100990334 100990357 24 - 2.166 2.225 0.196
ENSG00000117543 E013 141.5507530 0.0002540285 3.224232e-03 1.092781e-02 1 100990358 100990392 35 - 2.122 2.212 0.300
ENSG00000117543 E014 404.3357320 0.0003968088 7.426225e-01 8.314871e-01 1 100990393 100990628 236 - 2.613 2.619 0.019
ENSG00000117543 E015 149.8126170 0.0002763653 1.936740e-01 3.183984e-01 1 100990629 100990631 3 - 2.202 2.166 -0.120
ENSG00000117543 E016 226.5062046 0.0002094486 1.412659e-02 3.851260e-02 1 100992637 100992740 104 - 2.390 2.334 -0.187
ENSG00000117543 E017 191.5564184 0.0002125091 3.970089e-02 9.046608e-02 1 100995110 100995149 40 - 2.317 2.267 -0.167
ENSG00000117543 E018 233.4579122 0.0001712103 6.915380e-02 1.419714e-01 1 101001467 101001544 78 - 2.396 2.356 -0.133
ENSG00000117543 E019 132.6600881 0.0002392578 9.736452e-03 2.811458e-02 1 101001545 101001587 43 - 2.167 2.089 -0.261
ENSG00000117543 E020 3.2535813 0.0050193119 2.390606e-01 3.730063e-01 1 101005941 101006063 123 - 0.540 0.720 0.781
ENSG00000117543 E021 0.9275265 0.0164780980 6.792438e-01 7.834916e-01 1 101011591 101011649 59 - 0.322 0.248 -0.509
ENSG00000117543 E022 3.5135604 0.0235921522 5.776267e-02 1.227959e-01 1 101013649 101013709 61 - 0.505 0.804 1.289
ENSG00000117543 E023 222.9359575 0.0012346923 4.397434e-01 5.814883e-01 1 101013710 101013818 109 - 2.368 2.341 -0.092
ENSG00000117543 E024 308.2383838 0.0011095215 1.433074e-01 2.525127e-01 1 101021641 101021765 125 - 2.515 2.471 -0.147
ENSG00000117543 E025 7.0004092 0.0276211947 6.184757e-01 7.360932e-01 1 101021766 101022934 1169 - 0.939 0.855 -0.319
ENSG00000117543 E026 3.3268402 0.0047705176 4.814754e-03 1.541507e-02 1 101022935 101023329 395 - 0.793 0.334 -2.171
ENSG00000117543 E027 10.3109554 0.0497258216 1.162156e-02 3.263087e-02 1 101023330 101024969 1640 - 1.192 0.782 -1.528
ENSG00000117543 E028 4.1755654 0.1380566309 6.927166e-02 1.421526e-01 1 101024970 101025308 339 - 0.866 0.407 -2.033
ENSG00000117543 E029 334.0626738 0.0027420502 9.578901e-02 1.840703e-01 1 101025309 101025466 158 - 2.559 2.490 -0.229
ENSG00000117543 E030 2.1926278 0.0137363937 1.233031e-01 2.246788e-01 1 101025467 101025639 173 - 0.604 0.334 -1.382
ENSG00000117543 E031 1.7370348 0.0701535990 5.650107e-01 6.921946e-01 1 101025640 101025664 25 - 0.375 0.470 0.508
ENSG00000117543 E032 11.7337112 0.0078522532 3.344557e-01 4.782046e-01 1 101025665 101025682 18 - 1.058 1.150 0.332
ENSG00000117543 E033 192.5174160 0.0060173634 4.528290e-01 5.936413e-01 1 101025683 101025804 122 - 2.314 2.258 -0.188
ENSG00000117543 E034 13.4004408 0.0013034434 2.356077e-01 3.690931e-01 1 101025805 101026088 284 - 1.116 1.226 0.389