ENSG00000117523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338920 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding protein_coding 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 4.1388189 0.778751 4.3366376 0.7787510 0.8859149 2.4622580 0.07783750 0.01010000 0.08746667 0.07736667 5.955464e-02 3.446582e-29 FALSE TRUE
ENST00000367742 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding protein_coding 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 5.3269570 2.471204 8.9084079 2.4712039 1.3050297 1.8457459 0.10094167 0.03210000 0.17663333 0.14453333 7.302105e-02 3.446582e-29 FALSE TRUE
ENST00000426496 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding protein_coding 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 1.6690761 4.472010 0.0000000 1.3784233 0.0000000 -8.8080022 0.02176667 0.05746667 0.00000000 -0.05746667 4.042786e-10 3.446582e-29 FALSE TRUE
ENST00000492811 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding processed_transcript 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 5.0904462 1.640337 7.1292765 0.6353873 0.8232591 2.1130168 0.09463750 0.02130000 0.14170000 0.12040000 2.382792e-04 3.446582e-29   FALSE
ENST00000495585 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding protein_coding 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 5.5385123 7.877023 1.1646051 1.6053463 0.4092429 -2.7473051 0.08122917 0.10083333 0.02303333 -0.07780000 3.023858e-03 3.446582e-29 FALSE TRUE
ENST00000498596 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding protein_coding 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 15.3117290 41.288547 0.7075177 4.1601803 0.7075177 -5.8469328 0.20679167 0.53013333 0.01383333 -0.51630000 3.270327e-03 3.446582e-29 FALSE FALSE
ENST00000644916 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding protein_coding 61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 4.2218260 8.488929 0.0000000 1.3658143 0.0000000 -9.7311373 0.06164583 0.10840000 0.00000000 -0.10840000 3.446582e-29 3.446582e-29 FALSE TRUE
MSTRG.2588.10 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding   61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 3.8064160 0.000000 7.7472497 0.0000000 1.6538919 9.5994014 0.07465417 0.00000000 0.15630000 0.15630000 2.362704e-23 3.446582e-29 FALSE TRUE
MSTRG.2588.3 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding   61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 7.1578336 5.025869 8.0495164 1.4489067 0.9548801 0.6784524 0.12532083 0.06386667 0.15983333 0.09596667 1.380336e-02 3.446582e-29 FALSE TRUE
MSTRG.2588.6 ENSG00000117523 HEK293_OSMI2_2hA HEK293_TMG_2hB PRRC2C protein_coding   61.01923 77.89524 50.13416 1.660716 1.218715 -0.6356388 0.9298821 0.000000 2.7070175 0.0000000 1.3613678 8.0858801 0.01620000 0.00000000 0.05273333 0.05273333 1.436014e-01 3.446582e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117523 E001 0.0000000       1 171485300 171485500 201 +      
ENSG00000117523 E002 0.0000000       1 171485501 171485507 7 +      
ENSG00000117523 E003 0.2966881 0.0272179880 2.502383e-01   1 171485508 171485515 8 + 0.197 0.000 -18.418
ENSG00000117523 E004 0.2966881 0.0272179880 2.502383e-01   1 171485516 171485516 1 + 0.197 0.000 -18.420
ENSG00000117523 E005 0.7469680 0.0173895725 2.706063e-02 6.611412e-02 1 171485517 171485519 3 + 0.387 0.000 -19.743
ENSG00000117523 E006 0.7469680 0.0173895725 2.706063e-02 6.611412e-02 1 171485520 171485521 2 + 0.387 0.000 -19.743
ENSG00000117523 E007 1.4939360 0.0576857392 1.878758e-03 6.848926e-03 1 171485522 171485525 4 + 0.589 0.000 -20.744
ENSG00000117523 E008 2.2584075 0.0066271155 8.942628e-04 3.593878e-03 1 171485526 171485529 4 + 0.701 0.136 -3.452
ENSG00000117523 E009 7.6875295 0.0198514055 9.045015e-05 4.771528e-04 1 171485530 171485550 21 + 1.117 0.596 -2.035
ENSG00000117523 E010 9.7460447 0.0726593621 3.695559e-03 1.228332e-02 1 171485551 171485555 5 + 1.195 0.736 -1.723
ENSG00000117523 E011 99.0869610 0.0004736205 6.632794e-40 2.284660e-37 1 171485556 171485595 40 + 2.174 1.679 -1.664
ENSG00000117523 E012 169.6895853 0.0098625727 3.061330e-22 2.503063e-20 1 171485596 171485735 140 + 2.413 1.885 -1.767
ENSG00000117523 E013 0.8167960 0.0169578139 5.277152e-01 6.607452e-01 1 171509560 171512031 2472 + 0.197 0.323 0.939
ENSG00000117523 E014 244.0089597 0.0205430822 8.413683e-13 2.091520e-11 1 171512032 171512200 169 + 2.561 2.073 -1.631
ENSG00000117523 E015 0.0000000       1 171512201 171512994 794 +      
ENSG00000117523 E016 65.7021738 0.0059068978 1.265227e-13 3.544188e-12 1 171512995 171513000 6 + 1.975 1.566 -1.384
ENSG00000117523 E017 192.9422912 0.0144770922 5.118360e-15 1.758857e-13 1 171513001 171513172 172 + 2.456 1.983 -1.579
ENSG00000117523 E018 136.0460828 0.0003282193 4.224508e-36 1.108477e-33 1 171514536 171514630 95 + 2.279 1.898 -1.278
ENSG00000117523 E019 78.2946660 0.0003243715 7.796608e-21 5.522774e-19 1 171514631 171514645 15 + 2.037 1.672 -1.229
ENSG00000117523 E020 155.2445873 0.0029531779 8.738951e-22 6.782335e-20 1 171515734 171515859 126 + 2.330 1.978 -1.176
ENSG00000117523 E021 222.6838418 0.0078542847 2.193730e-14 6.863676e-13 1 171517591 171517814 224 + 2.485 2.138 -1.158
ENSG00000117523 E022 148.2116651 0.0043630507 5.827076e-13 1.484964e-11 1 171522177 171522259 83 + 2.289 2.005 -0.950
ENSG00000117523 E023 0.1482932 0.0427283667 4.160322e-01   1 171522515 171522556 42 + 0.000 0.136 17.852
ENSG00000117523 E024 186.6741145 0.0002183114 3.258035e-32 6.376291e-30 1 171523221 171523348 128 + 2.391 2.100 -0.974
ENSG00000117523 E025 99.9854515 0.0005462468 5.268064e-13 1.351414e-11 1 171523349 171523354 6 + 2.103 1.864 -0.801
ENSG00000117523 E026 0.2214452 0.0392559305 4.145894e-01   1 171523355 171523434 80 + 0.000 0.136 17.860
ENSG00000117523 E027 173.5133275 0.0008473398 4.848625e-16 1.908493e-14 1 171523435 171523522 88 + 2.332 2.115 -0.726
ENSG00000117523 E028 241.5749370 0.0086207064 9.589870e-03 2.775774e-02 1 171524821 171524965 145 + 2.429 2.332 -0.324
ENSG00000117523 E029 194.1619958 0.0117115975 6.082639e-01 7.280466e-01 1 171527791 171527844 54 + 2.288 2.294 0.020
ENSG00000117523 E030 712.2150217 0.0259359039 6.873260e-01 7.896891e-01 1 171532343 171532961 619 + 2.817 2.889 0.241
ENSG00000117523 E031 255.5188567 0.0115808478 6.847941e-01 7.876927e-01 1 171535428 171535597 170 + 2.404 2.415 0.038
ENSG00000117523 E032 87.6905556 0.0010490662 7.423998e-04 3.051870e-03 1 171536029 171536034 6 + 1.996 1.892 -0.351
ENSG00000117523 E033 253.3936200 0.0001775468 2.440884e-26 2.992997e-24 1 171536035 171536278 244 + 2.496 2.281 -0.717
ENSG00000117523 E034 278.7442042 0.0165889751 1.819063e-07 1.757079e-06 1 171537263 171537473 211 + 2.566 2.267 -0.999
ENSG00000117523 E035 1558.4438720 0.0170718240 3.965608e-08 4.364553e-07 1 171539971 171541829 1859 + 3.306 3.029 -0.922
ENSG00000117523 E036 483.6996280 0.0153796811 1.887219e-05 1.177357e-04 1 171541830 171542229 400 + 2.776 2.562 -0.713
ENSG00000117523 E037 316.4701930 0.0066760390 1.200227e-05 7.829599e-05 1 171545479 171545687 209 + 2.568 2.415 -0.507
ENSG00000117523 E038 266.4088035 0.0029195768 1.297836e-06 1.052125e-05 1 171550086 171550240 155 + 2.482 2.354 -0.427
ENSG00000117523 E039 652.8644634 0.0087880649 1.252765e-03 4.818837e-03 1 171557240 171557954 715 + 2.862 2.758 -0.345
ENSG00000117523 E040 282.5349219 0.0113105805 2.493861e-02 6.174422e-02 1 171557955 171558143 189 + 2.488 2.409 -0.264
ENSG00000117523 E041 122.8319928 0.0073318523 4.421893e-03 1.432358e-02 1 171561018 171561020 3 + 2.140 2.030 -0.369
ENSG00000117523 E042 236.3411489 0.0082991264 4.828282e-03 1.545316e-02 1 171561021 171561103 83 + 2.418 2.322 -0.322
ENSG00000117523 E043 344.6118706 0.0076737448 3.029238e-02 7.254296e-02 1 171566233 171566421 189 + 2.563 2.508 -0.183
ENSG00000117523 E044 392.9879867 0.0040778765 5.086432e-02 1.107152e-01 1 171566592 171566843 252 + 2.606 2.578 -0.094
ENSG00000117523 E045 238.5411909 0.0075854242 2.498448e-01 3.857253e-01 1 171568247 171568339 93 + 2.382 2.371 -0.036
ENSG00000117523 E046 237.4456046 0.0040915594 4.105569e-01 5.541575e-01 1 171571320 171571421 102 + 2.369 2.378 0.027
ENSG00000117523 E047 384.4992442 0.0047079376 9.511745e-01 9.734599e-01 1 171574927 171575128 202 + 2.561 2.606 0.150
ENSG00000117523 E048 374.5074214 0.0008236683 2.551595e-02 6.294249e-02 1 171577434 171577637 204 + 2.526 2.612 0.286
ENSG00000117523 E049 310.1207228 0.0005648453 3.313249e-05 1.949756e-04 1 171579354 171579466 113 + 2.420 2.549 0.432
ENSG00000117523 E050 344.5803561 0.0020897043 2.133121e-03 7.636885e-03 1 171579828 171579964 137 + 2.469 2.596 0.421
ENSG00000117523 E051 531.9413328 0.0006722191 3.070192e-07 2.834773e-06 1 171583956 171584187 232 + 2.651 2.786 0.451
ENSG00000117523 E052 338.4928508 0.0021790389 2.715311e-12 6.213402e-11 1 171584419 171584526 108 + 2.390 2.636 0.818
ENSG00000117523 E053 57.1576543 0.0140844567 1.226072e-02 3.415918e-02 1 171584527 171584541 15 + 1.636 1.859 0.756
ENSG00000117523 E054 303.8623565 0.0002168601 1.652990e-20 1.123221e-18 1 171587003 171587072 70 + 2.350 2.582 0.775
ENSG00000117523 E055 441.0803449 0.0001694902 1.978506e-22 1.654843e-20 1 171587073 171587221 149 + 2.527 2.734 0.690
ENSG00000117523 E056 198.5308871 0.0002356706 7.456501e-15 2.505075e-13 1 171587648 171587661 14 + 2.162 2.399 0.792
ENSG00000117523 E057 391.1495185 0.0005817494 6.417846e-14 1.874274e-12 1 171587662 171587751 90 + 2.485 2.678 0.644
ENSG00000117523 E058 527.8322912 0.0011825694 3.252757e-10 5.261933e-09 1 171588379 171588505 127 + 2.626 2.802 0.588
ENSG00000117523 E059 39.7084557 0.0009180917 8.470361e-05 4.502987e-04 1 171589369 171589605 237 + 1.457 1.715 0.881
ENSG00000117523 E060 158.2438404 0.0052064039 6.128351e-03 1.894578e-02 1 171591152 171591200 49 + 2.112 2.273 0.538
ENSG00000117523 E061 95.0694288 0.0023520012 7.235792e-04 2.983306e-03 1 171591201 171591204 4 + 1.880 2.059 0.603
ENSG00000117523 E062 14.7963702 0.0013689282 2.099881e-01 3.385235e-01 1 171591205 171591313 109 + 1.233 1.154 -0.282
ENSG00000117523 E063 3540.7560967 0.0107742283 9.724400e-22 7.510226e-20 1 171591587 171593511 1925 + 3.278 3.722 1.478