ENSG00000117500

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370280 ENSG00000117500 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED5 protein_coding protein_coding 49.50674 11.71462 81.64836 0.6571563 1.212659 2.800059 2.275019 0.4973412 2.995073 0.1503708 0.2069910 2.566372 0.06491667 0.0426000 0.03663333 -0.005966667 0.91197378 0.01342337 FALSE TRUE
ENST00000370282 ENSG00000117500 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED5 protein_coding protein_coding 49.50674 11.71462 81.64836 0.6571563 1.212659 2.800059 5.896412 1.4292014 10.755214 0.1634186 0.3804893 2.903037 0.12228750 0.1229000 0.13173333 0.008833333 0.88476504 0.01342337 FALSE TRUE
ENST00000370290 ENSG00000117500 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED5 protein_coding nonsense_mediated_decay 49.50674 11.71462 81.64836 0.6571563 1.212659 2.800059 24.457160 4.6990102 41.545767 0.4169346 1.4311267 3.141553 0.45222500 0.4003000 0.50860000 0.108300000 0.01342337 0.01342337 FALSE TRUE
ENST00000479918 ENSG00000117500 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED5 protein_coding protein_coding 49.50674 11.71462 81.64836 0.6571563 1.212659 2.800059 15.096088 4.0157057 22.872852 0.3461294 1.5416110 2.506953 0.32026250 0.3466667 0.27973333 -0.066933333 0.49674794 0.01342337 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117500 E001 3.3632690 0.0097382849 7.353559e-03 2.213639e-02 1 93149742 93149788 47 - 0.449 0.877 1.848
ENSG00000117500 E002 16.2705945 0.0025477401 9.261326e-04 3.706546e-03 1 93149789 93149957 169 - 1.050 1.363 1.108
ENSG00000117500 E003 227.1056598 0.0006654727 1.347199e-01 2.407082e-01 1 93149958 93151857 1900 - 2.220 2.251 0.104
ENSG00000117500 E004 1677.4953408 0.0032457502 3.354748e-03 1.130625e-02 1 93151858 93154195 2338 - 3.103 3.024 -0.261
ENSG00000117500 E005 138.6512256 0.0021795090 1.628338e-07 1.588485e-06 1 93154196 93154231 36 - 2.049 1.741 -1.037
ENSG00000117500 E006 907.5785806 0.0007000248 3.500241e-01 4.941981e-01 1 93154232 93154888 657 - 2.831 2.793 -0.125
ENSG00000117500 E007 7.6437315 0.0021954934 3.957996e-03 1.302513e-02 1 93156036 93156039 4 - 0.733 1.095 1.379
ENSG00000117500 E008 10.1017256 0.0016910008 4.648461e-03 1.495444e-02 1 93156040 93156084 45 - 0.850 1.173 1.192
ENSG00000117500 E009 6.1970422 0.0027243292 1.093541e-01 2.046125e-01 1 93156085 93156299 215 - 0.700 0.922 0.874
ENSG00000117500 E010 533.1327029 0.0002089564 1.145558e-01 2.121950e-01 1 93156300 93156483 184 - 2.592 2.605 0.043
ENSG00000117500 E011 15.0049817 0.0082603576 1.124543e-05 7.384190e-05 1 93158815 93158885 71 - 0.968 1.408 1.570
ENSG00000117500 E012 344.8561775 0.0012150823 7.018807e-03 2.127218e-02 1 93160129 93160226 98 - 2.395 2.455 0.198
ENSG00000117500 E013 0.5964967 0.0209326411 5.025801e-01 6.386315e-01 1 93160227 93163210 2984 - 0.143 0.259 1.072
ENSG00000117500 E014 496.5589310 0.0027657507 1.377374e-03 5.232738e-03 1 93180054 93180516 463 - 2.549 2.627 0.258