ENSG00000117475

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329281 ENSG00000117475 HEK293_OSMI2_2hA HEK293_TMG_2hB BLZF1 protein_coding protein_coding 8.250669 2.124936 13.92464 0.2564562 0.4852376 2.706411 0.6684711 0.17185759 1.072778 0.01542524 0.2056225 2.573856 0.10101667 0.08266667 0.07620000 -0.006466667 8.767240e-01 5.745625e-06 FALSE TRUE
ENST00000367807 ENSG00000117475 HEK293_OSMI2_2hA HEK293_TMG_2hB BLZF1 protein_coding protein_coding 8.250669 2.124936 13.92464 0.2564562 0.4852376 2.706411 0.7694718 0.07607556 1.191255 0.01831442 0.1017320 3.802795 0.06402083 0.03523333 0.08546667 0.050233333 8.428605e-02 5.745625e-06 FALSE TRUE
ENST00000367808 ENSG00000117475 HEK293_OSMI2_2hA HEK293_TMG_2hB BLZF1 protein_coding protein_coding 8.250669 2.124936 13.92464 0.2564562 0.4852376 2.706411 5.4927676 1.73894911 8.414341 0.13675817 0.3214965 2.268075 0.73133750 0.82823333 0.60440000 -0.223833333 7.045030e-03 5.745625e-06 FALSE TRUE
ENST00000426663 ENSG00000117475 HEK293_OSMI2_2hA HEK293_TMG_2hB BLZF1 protein_coding protein_coding 8.250669 2.124936 13.92464 0.2564562 0.4852376 2.706411 1.2771990 0.05445605 3.246271 0.05445605 0.1409559 5.658761 0.09737500 0.02123333 0.23386667 0.212633333 5.745625e-06 5.745625e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117475 E001 0.4439371 0.0216291052 8.434615e-01 9.025309e-01 1 169367970 169367971 2 + 0.157 0.001 -7.510
ENSG00000117475 E002 10.0102770 0.0154942779 9.281785e-01 9.587873e-01 1 169367972 169368194 223 + 0.946 0.956 0.039
ENSG00000117475 E003 17.2671896 0.0037674360 7.897166e-02 1.578691e-01 1 169368195 169368236 42 + 1.195 0.990 -0.741
ENSG00000117475 E004 33.9361189 0.0013704834 6.057183e-02 1.275896e-01 1 169368237 169368342 106 + 1.469 1.316 -0.529
ENSG00000117475 E005 1.1029768 0.0113792444 8.932251e-01 9.357746e-01 1 169368343 169368362 20 + 0.272 0.238 -0.254
ENSG00000117475 E006 23.3815680 0.0008887378 1.357479e-01 2.421520e-01 1 169369473 169369481 9 + 1.314 1.172 -0.499
ENSG00000117475 E007 38.5787801 0.0005607967 5.329245e-03 1.682795e-02 1 169369482 169369550 69 + 1.533 1.316 -0.748
ENSG00000117475 E008 116.9426517 0.0002987784 2.308194e-03 8.177134e-03 1 169376540 169376979 440 + 1.993 1.869 -0.417
ENSG00000117475 E009 5.8454015 0.0029624904 8.933762e-01 9.358495e-01 1 169376980 169377383 404 + 0.752 0.731 -0.085
ENSG00000117475 E010 72.0661908 0.0003935420 1.155760e-01 2.136684e-01 1 169378330 169378529 200 + 1.780 1.698 -0.277
ENSG00000117475 E011 62.7211252 0.0003875587 5.508062e-01 6.803701e-01 1 169380481 169380609 129 + 1.711 1.678 -0.109
ENSG00000117475 E012 61.7420101 0.0024951430 4.742988e-01 6.131445e-01 1 169382062 169382281 220 + 1.688 1.729 0.138
ENSG00000117475 E013 60.6413929 0.0004611771 8.966805e-02 1.746160e-01 1 169386997 169387209 213 + 1.672 1.763 0.307
ENSG00000117475 E014 116.8860793 0.0002949346 1.743705e-09 2.470938e-08 1 169387210 169388305 1096 + 1.922 2.131 0.701
ENSG00000117475 E015 6.4624179 0.0027617817 6.794932e-03 2.068982e-02 1 169395894 169396540 647 + 0.692 1.050 1.382