ENSG00000117448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351829 ENSG00000117448 HEK293_OSMI2_2hA HEK293_TMG_2hB AKR1A1 protein_coding protein_coding 98.03468 167.1585 72.1016 4.523511 1.002984 -1.213 29.502452 58.458210 15.154098 4.0638038 1.1254754 -1.9469928 0.28336667 0.34896667 0.21066667 -0.138300000 0.0006137812 0.0006137812 FALSE TRUE
ENST00000434299 ENSG00000117448 HEK293_OSMI2_2hA HEK293_TMG_2hB AKR1A1 protein_coding protein_coding 98.03468 167.1585 72.1016 4.523511 1.002984 -1.213 9.536114 14.289044 11.445119 2.7010044 0.7584751 -0.3199263 0.09575417 0.08473333 0.15856667 0.073833333 0.0274557320 0.0006137812 FALSE FALSE
ENST00000471651 ENSG00000117448 HEK293_OSMI2_2hA HEK293_TMG_2hB AKR1A1 protein_coding protein_coding 98.03468 167.1585 72.1016 4.523511 1.002984 -1.213 5.251153 5.827341 3.661615 0.8340554 0.2747271 -0.6688964 0.06369583 0.03463333 0.05080000 0.016166667 0.1663908694 0.0006137812 FALSE TRUE
ENST00000473038 ENSG00000117448 HEK293_OSMI2_2hA HEK293_TMG_2hB AKR1A1 protein_coding processed_transcript 98.03468 167.1585 72.1016 4.523511 1.002984 -1.213 5.610296 7.057773 3.629685 0.4650075 0.3309820 -0.9574420 0.06650417 0.04216667 0.05046667 0.008300000 0.5769058694 0.0006137812 FALSE TRUE
ENST00000621846 ENSG00000117448 HEK293_OSMI2_2hA HEK293_TMG_2hB AKR1A1 protein_coding protein_coding 98.03468 167.1585 72.1016 4.523511 1.002984 -1.213 21.093363 39.844997 17.084788 2.6944197 0.7739131 -1.2212041 0.20675833 0.23956667 0.23673333 -0.002833333 1.0000000000 0.0006137812 FALSE TRUE
MSTRG.1084.8 ENSG00000117448 HEK293_OSMI2_2hA HEK293_TMG_2hB AKR1A1 protein_coding   98.03468 167.1585 72.1016 4.523511 1.002984 -1.213 11.688245 20.389029 9.600611 2.2054333 0.7971128 -1.0858004 0.11974167 0.12273333 0.13346667 0.010733333 0.8676431212 0.0006137812 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117448 E001 0.6998377 1.669943e-02 2.932980e-01 4.343347e-01 1 45550503 45550536 34 + 0.326 0.140 -1.562
ENSG00000117448 E002 0.6998377 1.669943e-02 2.932980e-01 4.343347e-01 1 45550537 45550538 2 + 0.326 0.139 -1.564
ENSG00000117448 E003 0.6998377 1.669943e-02 2.932980e-01 4.343347e-01 1 45550539 45550542 4 + 0.326 0.139 -1.564
ENSG00000117448 E004 1.9446868 2.071891e-02 5.847043e-01 7.085664e-01 1 45550543 45550782 240 + 0.326 0.432 0.606
ENSG00000117448 E005 2.6957071 6.193902e-03 1.544444e-01 2.676775e-01 1 45550783 45550803 21 + 0.692 0.461 -1.054
ENSG00000117448 E006 7.2254473 2.303210e-03 2.448792e-02 6.082951e-02 1 45550804 45550813 10 + 1.045 0.772 -1.036
ENSG00000117448 E007 32.0733199 6.263566e-04 3.509796e-02 8.183031e-02 1 45550814 45550825 12 + 1.546 1.405 -0.486
ENSG00000117448 E008 75.8981444 3.467005e-04 3.981842e-01 5.419245e-01 1 45550826 45550845 20 + 1.834 1.796 -0.129
ENSG00000117448 E009 96.3907197 2.859409e-04 3.979679e-01 5.417065e-01 1 45550846 45550853 8 + 1.932 1.898 -0.115
ENSG00000117448 E010 206.0002186 2.614910e-03 4.498802e-01 5.910749e-01 1 45550854 45550876 23 + 2.253 2.225 -0.092
ENSG00000117448 E011 269.0432832 1.689886e-04 5.780633e-02 1.228695e-01 1 45550877 45550965 89 + 2.307 2.358 0.170
ENSG00000117448 E012 533.2369993 1.260133e-04 3.444496e-01 4.885449e-01 1 45550966 45551066 101 + 2.657 2.641 -0.053
ENSG00000117448 E013 305.1702900 1.744626e-04 4.824311e-01 6.205662e-01 1 45551067 45551067 1 + 2.415 2.399 -0.053
ENSG00000117448 E014 679.4733076 5.190088e-04 8.045217e-01 8.756415e-01 1 45551068 45551155 88 + 2.751 2.747 -0.012
ENSG00000117448 E015 2.1819143 6.753284e-03 2.977159e-01 4.390639e-01 1 45552416 45552435 20 + 0.580 0.400 -0.888
ENSG00000117448 E016 252.3147325 3.053740e-04 3.173492e-10 5.146453e-09 1 45552436 45552563 128 + 2.438 2.279 -0.532
ENSG00000117448 E017 0.0000000       1 45557082 45557119 38 +      
ENSG00000117448 E018 698.4471737 4.473772e-04 6.139805e-02 1.289880e-01 1 45561789 45561878 90 + 2.785 2.753 -0.108
ENSG00000117448 E019 937.9754334 2.968681e-04 8.611681e-03 2.531695e-02 1 45566569 45566688 120 + 2.918 2.880 -0.126
ENSG00000117448 E020 1005.2005820 1.264490e-04 7.820061e-04 3.194995e-03 1 45566869 45567020 152 + 2.952 2.909 -0.144
ENSG00000117448 E021 114.2933078 6.708945e-04 3.828474e-09 5.094065e-08 1 45567021 45567548 528 + 2.137 1.918 -0.735
ENSG00000117448 E022 39.5173449 1.482353e-02 1.272137e-01 2.302543e-01 1 45567549 45567756 208 + 1.616 1.489 -0.434
ENSG00000117448 E023 51.9010419 1.193428e-03 1.141017e-02 3.214022e-02 1 45567757 45567960 204 + 1.743 1.602 -0.478
ENSG00000117448 E024 29.9791612 3.146856e-03 1.357675e-03 5.168858e-03 1 45567961 45567981 21 + 1.579 1.350 -0.790
ENSG00000117448 E025 951.6030463 8.700497e-05 3.511850e-01 4.953979e-01 1 45567982 45568090 109 + 2.904 2.893 -0.037
ENSG00000117448 E026 650.9469380 1.496690e-04 1.844339e-01 3.067857e-01 1 45568091 45568146 56 + 2.713 2.737 0.079
ENSG00000117448 E027 559.5799501 7.174354e-04 3.473595e-02 8.114307e-02 1 45568147 45568177 31 + 2.629 2.677 0.158
ENSG00000117448 E028 629.7592662 1.078337e-04 1.220144e-07 1.219224e-06 1 45568485 45568613 129 + 2.642 2.735 0.311
ENSG00000117448 E029 470.1431035 1.560467e-04 4.349265e-05 2.486211e-04 1 45568614 45568684 71 + 2.522 2.606 0.280
ENSG00000117448 E030 19.8396186 1.332487e-03 1.044016e-01 1.971883e-01 1 45568685 45568926 242 + 1.348 1.212 -0.475
ENSG00000117448 E031 439.3068450 3.045974e-04 2.382155e-02 5.944722e-02 1 45568927 45568933 7 + 2.523 2.572 0.166
ENSG00000117448 E032 704.2385485 7.161278e-04 6.345565e-03 1.952205e-02 1 45568934 45568999 66 + 2.722 2.778 0.187
ENSG00000117448 E033 6.9923448 2.558030e-03 3.561459e-01 5.005362e-01 1 45569000 45569006 7 + 0.918 0.799 -0.459
ENSG00000117448 E034 10.8444966 1.628747e-03 1.780655e-01 2.987105e-01 1 45569050 45569142 93 + 1.106 0.961 -0.532
ENSG00000117448 E035 691.5981369 3.418366e-04 3.788349e-02 8.713218e-02 1 45569143 45569229 87 + 2.728 2.766 0.129
ENSG00000117448 E036 512.5571255 1.343722e-03 6.453532e-03 1.980243e-02 1 45569891 45570049 159 + 2.572 2.643 0.237