ENSG00000117408

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372339 ENSG00000117408 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO13 protein_coding protein_coding 43.50467 58.45954 26.79676 3.709792 0.801225 -1.125088 3.273952 3.840661 1.6985470 0.4052558 0.3534205 -1.172336296 0.07271250 0.06693333 0.06270000 -0.004233333 9.465885e-01 2.300231e-05 FALSE  
ENST00000372343 ENSG00000117408 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO13 protein_coding protein_coding 43.50467 58.45954 26.79676 3.709792 0.801225 -1.125088 23.644940 31.252342 15.1440377 2.5825727 0.6586131 -1.044723604 0.54930000 0.53500000 0.56473333 0.029733333 7.902568e-01 2.300231e-05 FALSE  
ENST00000480902 ENSG00000117408 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO13 protein_coding processed_transcript 43.50467 58.45954 26.79676 3.709792 0.801225 -1.125088 5.343470 4.432431 4.4198791 0.7989098 0.2406241 -0.004082083 0.13019583 0.07470000 0.16486667 0.090166667 2.300231e-05 2.300231e-05    
MSTRG.1025.3 ENSG00000117408 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO13 protein_coding   43.50467 58.45954 26.79676 3.709792 0.801225 -1.125088 1.952155 4.338059 0.6603665 0.6801647 0.1116173 -2.697349713 0.03992500 0.07536667 0.02496667 -0.050400000 9.546904e-03 2.300231e-05 FALSE  
MSTRG.1025.4 ENSG00000117408 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO13 protein_coding   43.50467 58.45954 26.79676 3.709792 0.801225 -1.125088 2.659261 4.849286 1.4169303 0.2831577 0.2489992 -1.767829464 0.05959583 0.08350000 0.05243333 -0.031066667 1.107781e-01 2.300231e-05 TRUE  
MSTRG.1025.9 ENSG00000117408 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO13 protein_coding   43.50467 58.45954 26.79676 3.709792 0.801225 -1.125088 2.503468 3.707234 1.1648438 0.1830824 0.2224632 -1.661760414 0.05750000 0.06356667 0.04306667 -0.020500000 2.303118e-01 2.300231e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117408 E001 136.1172639 0.0002634192 3.992817e-15 1.393822e-13 1 43946950 43947086 137 + 2.235 1.991 -0.816
ENSG00000117408 E002 273.9815750 0.0003036230 1.801443e-29 2.879983e-27 1 43947087 43947423 337 + 2.544 2.291 -0.844
ENSG00000117408 E003 59.3049967 0.0014584821 1.551335e-09 2.220595e-08 1 43947424 43947436 13 + 1.915 1.624 -0.983
ENSG00000117408 E004 105.2825513 0.0030121523 8.450242e-09 1.055637e-07 1 43947437 43947554 118 + 2.128 1.883 -0.822
ENSG00000117408 E005 60.0616375 0.0027108851 9.471811e-08 9.656690e-07 1 43947555 43947569 15 + 1.904 1.632 -0.920
ENSG00000117408 E006 110.3233096 0.0029211438 3.391301e-08 3.781916e-07 1 43947570 43947684 115 + 2.138 1.909 -0.769
ENSG00000117408 E007 13.9593436 0.0285587084 2.633120e-01 4.011848e-01 1 43949372 43949416 45 + 1.185 1.065 -0.432
ENSG00000117408 E008 549.9680714 0.0019377625 4.472068e-02 9.969051e-02 1 43949417 43950085 669 + 2.699 2.659 -0.130
ENSG00000117408 E009 171.8288994 0.0002351410 8.598324e-01 9.136030e-01 1 43950086 43950153 68 + 2.161 2.166 0.017
ENSG00000117408 E010 0.7782011 0.0163285391 1.247682e-01 2.268013e-01 1 43953217 43953483 267 + 0.414 0.146 -1.996
ENSG00000117408 E011 256.3552005 0.0033806075 1.124462e-01 2.091093e-01 1 43956320 43956460 141 + 2.370 2.326 -0.148
ENSG00000117408 E012 311.2902951 0.0012755388 7.277089e-03 2.194455e-02 1 43956560 43956701 142 + 2.467 2.405 -0.206
ENSG00000117408 E013 309.2153483 0.0052676072 2.354583e-01 3.689110e-01 1 43956810 43956976 167 + 2.444 2.411 -0.109
ENSG00000117408 E014 18.5284555 0.0009678163 2.515644e-04 1.181733e-03 1 43957109 43957194 86 + 1.423 1.133 -1.018
ENSG00000117408 E015 263.4015004 0.0025216691 1.174811e-01 2.163501e-01 1 43957195 43957315 121 + 2.380 2.340 -0.134
ENSG00000117408 E016 332.1273569 0.0002712478 9.878133e-04 3.916829e-03 1 43957402 43957549 148 + 2.496 2.432 -0.211
ENSG00000117408 E017 349.8453469 0.0001766611 8.509596e-01 9.075805e-01 1 43957977 43958158 182 + 2.461 2.476 0.050
ENSG00000117408 E018 157.4982728 0.0021338140 7.696114e-02 1.546283e-01 1 43958242 43958268 27 + 2.065 2.147 0.274
ENSG00000117408 E019 317.6148048 0.0028215954 2.819211e-01 4.218769e-01 1 43958461 43958595 135 + 2.395 2.443 0.162
ENSG00000117408 E020 336.4158920 0.0002399648 2.486561e-02 6.159568e-02 1 43958746 43958889 144 + 2.406 2.469 0.210
ENSG00000117408 E021 25.5078306 0.0007478709 2.289750e-01 3.612186e-01 1 43958890 43958983 94 + 1.414 1.334 -0.279
ENSG00000117408 E022 18.2371637 0.0013696407 3.451860e-03 1.158716e-02 1 43960006 43960248 243 + 1.377 1.139 -0.836
ENSG00000117408 E023 244.4180035 0.0001903536 5.448778e-08 5.824707e-07 1 43960249 43960329 81 + 2.186 2.349 0.545
ENSG00000117408 E024 357.9972773 0.0001535160 3.165862e-04 1.447060e-03 1 43960876 43961013 138 + 2.410 2.502 0.305
ENSG00000117408 E025 355.3733922 0.0001457971 4.967039e-03 1.583786e-02 1 43961166 43961262 97 + 2.422 2.495 0.245
ENSG00000117408 E026 255.1484874 0.0001725296 5.019508e-02 1.095020e-01 1 43964269 43964321 53 + 2.288 2.350 0.207
ENSG00000117408 E027 56.3677064 0.0196123246 1.281436e-01 2.315758e-01 1 43965939 43966574 636 + 1.782 1.659 -0.414
ENSG00000117408 E028 268.6797149 0.0002746943 7.589405e-06 5.181412e-05 1 43966575 43966641 67 + 2.255 2.386 0.437
ENSG00000117408 E029 268.4306455 0.0032749406 6.003420e-04 2.534327e-03 1 43966724 43966782 59 + 2.246 2.390 0.480
ENSG00000117408 E030 288.4479275 0.0031568044 2.845797e-04 1.317194e-03 1 43966930 43967019 90 + 2.274 2.421 0.491
ENSG00000117408 E031 13.2465876 0.0025066502 6.182341e-02 1.296909e-01 1 43967160 43967314 155 + 1.215 1.041 -0.625
ENSG00000117408 E032 465.1378151 0.0055578327 2.122085e-05 1.307943e-04 1 43967315 43967496 182 + 2.448 2.636 0.625
ENSG00000117408 E033 517.7525157 0.0047106827 4.226547e-05 2.422566e-04 1 43967586 43968022 437 + 2.512 2.679 0.557