ENSG00000117394

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426263 ENSG00000117394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A1 protein_coding protein_coding 62.70988 66.79852 46.55522 3.462074 1.240233 -0.5207792 3.645328 4.472127 2.634693 0.0802079 0.1103769 -0.7610833 0.05897917 0.06723333 0.05653333 -0.01070000 0.42397729 0.01645271 FALSE  
ENST00000630287 ENSG00000117394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A1 protein_coding nonsense_mediated_decay 62.70988 66.79852 46.55522 3.462074 1.240233 -0.5207792 33.933865 40.096939 24.557784 1.7282332 0.5434119 -0.7070841 0.54070833 0.60106667 0.52766667 -0.07340000 0.01645271 0.01645271 FALSE  
ENST00000674765 ENSG00000117394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A1 protein_coding protein_coding 62.70988 66.79852 46.55522 3.462074 1.240233 -0.5207792 16.716124 14.873484 13.399546 1.3312702 1.4444531 -0.1504518 0.26642917 0.22213333 0.28666667 0.06453333 0.24552380 0.01645271 FALSE  
ENST00000675112 ENSG00000117394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC2A1 protein_coding retained_intron 62.70988 66.79852 46.55522 3.462074 1.240233 -0.5207792 5.279428 3.106452 4.504686 0.7591532 0.8428295 0.5347215 0.08404167 0.04573333 0.09786667 0.05213333 0.13606274 0.01645271 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117394 E001 34.5591969 6.391119e-04 2.334381e-01 3.664792e-01 1 42925353 42926155 803 - 1.468 1.560 0.317
ENSG00000117394 E002 18.8892886 1.241200e-03 4.965877e-02 1.085538e-01 1 42926156 42926168 13 - 1.151 1.335 0.649
ENSG00000117394 E003 34.6340226 4.707227e-03 1.103767e-04 5.697383e-04 1 42926169 42926173 5 - 1.308 1.614 1.056
ENSG00000117394 E004 100.9345192 4.430551e-03 4.046384e-12 8.977344e-11 1 42926174 42926243 70 - 1.698 2.085 1.302
ENSG00000117394 E005 85.0832405 3.359184e-03 2.773666e-14 8.542719e-13 1 42926244 42926248 5 - 1.589 2.019 1.452
ENSG00000117394 E006 1027.9422245 3.299287e-03 3.026541e-10 4.921624e-09 1 42926249 42926795 547 - 2.851 3.047 0.650
ENSG00000117394 E007 235.8333033 7.094056e-03 1.097196e-04 5.666555e-04 1 42926796 42926857 62 - 2.203 2.410 0.692
ENSG00000117394 E008 427.6105896 4.064872e-03 2.659519e-04 1.240949e-03 1 42926858 42926978 121 - 2.505 2.653 0.494
ENSG00000117394 E009 818.7951628 2.659096e-04 1.933162e-02 5.005216e-02 1 42926979 42927241 263 - 2.853 2.905 0.175
ENSG00000117394 E010 649.7017320 9.666633e-05 4.116226e-03 1.346909e-02 1 42927605 42927808 204 - 2.802 2.779 -0.075
ENSG00000117394 E011 4.2885142 2.519658e-02 4.902133e-01 6.275599e-01 1 42927809 42928931 1123 - 0.773 0.685 -0.362
ENSG00000117394 E012 264.7604218 1.560372e-04 1.900842e-02 4.935229e-02 1 42928932 42928976 45 - 2.421 2.386 -0.116
ENSG00000117394 E013 288.6755170 1.494697e-04 1.753330e-02 4.611135e-02 1 42928977 42929033 57 - 2.457 2.424 -0.111
ENSG00000117394 E014 2.5278090 7.273542e-02 8.489915e-02 1.672461e-01 1 42929034 42929209 176 - 0.709 0.404 -1.420
ENSG00000117394 E015 387.0622709 1.662095e-04 1.068177e-01 2.008566e-01 1 42929210 42929314 105 - 2.571 2.559 -0.041
ENSG00000117394 E016 5.0520553 4.302314e-03 7.994599e-02 1.594812e-01 1 42929315 42929592 278 - 0.902 0.687 -0.855
ENSG00000117394 E017 221.2190489 1.966994e-04 3.854152e-01 5.295986e-01 1 42929593 42929639 47 - 2.294 2.335 0.134
ENSG00000117394 E018 328.7165001 1.994522e-04 6.568953e-02 1.361964e-01 1 42929640 42929733 94 - 2.504 2.484 -0.066
ENSG00000117394 E019 240.7128352 2.074131e-04 4.406629e-04 1.930583e-03 1 42929734 42929780 47 - 2.400 2.335 -0.218
ENSG00000117394 E020 385.6646540 8.459200e-04 2.571751e-03 8.979351e-03 1 42929873 42930035 163 - 2.593 2.544 -0.162
ENSG00000117394 E021 3.4279119 4.745112e-03 3.552373e-01 4.996039e-01 1 42930319 42930625 307 - 0.708 0.584 -0.535
ENSG00000117394 E022 272.2432037 1.617462e-03 7.467153e-04 3.066615e-03 1 42930626 42930697 72 - 2.459 2.382 -0.256
ENSG00000117394 E023 414.1412067 3.382550e-03 6.671883e-04 2.778319e-03 1 42930698 42930866 169 - 2.649 2.561 -0.291
ENSG00000117394 E024 1.5404825 9.247658e-03 4.067892e-02 9.228568e-02 1 42930960 42931045 86 - 0.588 0.249 -1.895
ENSG00000117394 E025 414.3040843 1.483759e-03 3.891164e-10 6.218214e-09 1 42931046 42931206 161 - 2.676 2.542 -0.448
ENSG00000117394 E026 3.1217580 4.908041e-03 3.864232e-01 5.306065e-01 1 42931207 42931769 563 - 0.485 0.639 0.707
ENSG00000117394 E027 0.7029582 1.660300e-02 5.999247e-01 7.212551e-01 1 42942966 42943225 260 - 0.149 0.249 0.913
ENSG00000117394 E028 282.7183975 5.680057e-04 8.087216e-10 1.220212e-08 1 42943226 42943321 96 - 2.505 2.378 -0.423
ENSG00000117394 E029 7.8552076 4.238858e-02 4.449449e-02 9.927674e-02 1 42951616 42951930 315 - 0.672 1.013 1.332
ENSG00000117394 E030 0.2214452 3.801055e-02 7.695605e-01   1 42951931 42952016 86 - 0.000 0.100 8.055
ENSG00000117394 E031 0.0000000       1 42954344 42954354 11 -      
ENSG00000117394 E032 317.4121367 3.210028e-03 6.813360e-06 4.705175e-05 1 42958634 42958893 260 - 2.557 2.430 -0.426