ENSG00000117360

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324862 ENSG00000117360 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF3 protein_coding protein_coding 53.04148 39.81641 63.3942 2.373975 0.236367 0.670853 41.925893 34.629036 50.597763 2.2305951 0.3003190 0.5469599 0.78378750 0.86923333 0.79816667 -0.07106667 5.293213e-05 3.112413e-07 FALSE TRUE
ENST00000470824 ENSG00000117360 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF3 protein_coding processed_transcript 53.04148 39.81641 63.3942 2.373975 0.236367 0.670853 2.988262 1.446679 2.267219 0.2439390 0.1175987 0.6445899 0.06219167 0.03603333 0.03573333 -0.00030000 1.000000e+00 3.112413e-07   FALSE
ENST00000476970 ENSG00000117360 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF3 protein_coding processed_transcript 53.04148 39.81641 63.3942 2.373975 0.236367 0.670853 3.879591 1.686326 5.274034 0.1549881 0.5169227 1.6392264 0.07305417 0.04256667 0.08323333 0.04066667 6.221509e-03 3.112413e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117360 E001 10.6086635 0.0027273627 5.188858e-01 6.530136e-01 1 150321479 150321532 54 + 1.088 1.024 -0.233
ENSG00000117360 E002 144.5635801 0.0002088655 1.495701e-12 3.560645e-11 1 150321533 150321592 60 + 2.255 2.045 -0.702
ENSG00000117360 E003 345.4489180 0.0031414426 6.413327e-05 3.516703e-04 1 150324895 150325087 193 + 2.600 2.470 -0.431
ENSG00000117360 E004 297.3668958 0.0069416124 1.213751e-01 2.218877e-01 1 150325751 150325881 131 + 2.509 2.438 -0.237
ENSG00000117360 E005 9.2233332 0.0076836417 4.155573e-04 1.833995e-03 1 150327557 150327652 96 + 1.171 0.761 -1.539
ENSG00000117360 E006 1.8884630 0.0077176894 6.948737e-01 7.955962e-01 1 150327775 150328319 545 + 0.436 0.505 0.348
ENSG00000117360 E007 318.4458143 0.0050224441 6.425260e-03 1.972783e-02 1 150328320 150328466 147 + 2.555 2.445 -0.364
ENSG00000117360 E008 28.4959493 0.0257788658 2.181048e-01 3.481338e-01 1 150329752 150330498 747 + 1.411 1.524 0.390
ENSG00000117360 E009 262.1829100 0.0016795116 1.932384e-04 9.348904e-04 1 150332684 150332767 84 + 2.471 2.362 -0.363
ENSG00000117360 E010 416.8143057 0.0024057735 5.531313e-03 1.736931e-02 1 150332979 150333199 221 + 2.659 2.581 -0.261
ENSG00000117360 E011 567.9722822 0.0001075276 3.627945e-04 1.629917e-03 1 150334935 150335241 307 + 2.781 2.732 -0.164
ENSG00000117360 E012 410.6599570 0.0004509381 4.175701e-01 5.609094e-01 1 150338160 150338326 167 + 2.624 2.611 -0.042
ENSG00000117360 E013 315.1533848 0.0020008346 1.452243e-01 2.551452e-01 1 150340398 150340477 80 + 2.521 2.481 -0.134
ENSG00000117360 E014 1.0445985 0.2815628004 8.634112e-01 9.158953e-01 1 150343151 150343308 158 + 0.334 0.314 -0.126
ENSG00000117360 E015 419.3666120 0.0015352210 7.262054e-01 8.192810e-01 1 150343309 150343452 144 + 2.620 2.631 0.036
ENSG00000117360 E016 331.8894916 0.0001416480 1.168742e-01 2.155097e-01 1 150344162 150344261 100 + 2.508 2.542 0.114
ENSG00000117360 E017 0.7352129 0.0980819476 2.931798e-01 4.342240e-01 1 150344262 150344375 114 + 0.333 0.135 -1.656
ENSG00000117360 E018 2.6175342 0.0065756811 5.982268e-01 7.198762e-01 1 150344376 150344433 58 + 0.589 0.506 -0.386
ENSG00000117360 E019 356.5312228 0.0001714736 1.834718e-05 1.147930e-04 1 150344434 150344547 114 + 2.512 2.597 0.282
ENSG00000117360 E020 39.0177973 0.0044801082 6.629513e-08 6.972030e-07 1 150345540 150346017 478 + 1.740 1.377 -1.240
ENSG00000117360 E021 156.9001557 0.0003865978 1.627753e-04 8.038502e-04 1 150346018 150346019 2 + 2.140 2.253 0.377
ENSG00000117360 E022 411.5984649 0.0003169124 2.941615e-07 2.727353e-06 1 150346020 150346136 117 + 2.566 2.665 0.328
ENSG00000117360 E023 47.2341438 0.0097049772 1.106852e-03 4.326268e-03 1 150346137 150346407 271 + 1.779 1.550 -0.777
ENSG00000117360 E024 363.9483782 0.0023834768 2.072467e-03 7.448591e-03 1 150346408 150346491 84 + 2.516 2.609 0.309
ENSG00000117360 E025 26.3404153 0.0007756645 6.895992e-02 1.416486e-01 1 150348684 150349156 473 + 1.495 1.376 -0.410
ENSG00000117360 E026 355.8856376 0.0028433194 2.651859e-04 1.237955e-03 1 150349157 150349218 62 + 2.494 2.611 0.389
ENSG00000117360 E027 512.5157881 0.0031540724 2.070593e-09 2.891336e-08 1 150352833 150353244 412 + 2.613 2.798 0.614