ENSG00000117335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354848 ENSG00000117335 HEK293_OSMI2_2hA HEK293_TMG_2hB CD46 protein_coding protein_coding 30.13586 8.727879 41.69269 0.6822342 1.701613 2.254785 5.984413 2.2583721 8.212989 0.3244198 0.5273193 1.858006 0.21253750 0.2570000 0.1972000 -0.0598000 2.367972e-01 7.060095e-11 FALSE TRUE
ENST00000357714 ENSG00000117335 HEK293_OSMI2_2hA HEK293_TMG_2hB CD46 protein_coding protein_coding 30.13586 8.727879 41.69269 0.6822342 1.701613 2.254785 7.096849 2.6288639 5.946569 0.4824956 0.5525732 1.174565 0.22664583 0.3088667 0.1436000 -0.1652667 9.729004e-02 7.060095e-11 FALSE TRUE
ENST00000367041 ENSG00000117335 HEK293_OSMI2_2hA HEK293_TMG_2hB CD46 protein_coding protein_coding 30.13586 8.727879 41.69269 0.6822342 1.701613 2.254785 2.769592 1.4695256 3.532564 0.7684466 1.9683538 1.259659 0.13104167 0.1618000 0.0850000 -0.0768000 7.747818e-01 7.060095e-11 FALSE TRUE
ENST00000367042 ENSG00000117335 HEK293_OSMI2_2hA HEK293_TMG_2hB CD46 protein_coding protein_coding 30.13586 8.727879 41.69269 0.6822342 1.701613 2.254785 5.163766 0.9589269 10.067306 0.2347942 0.6961873 3.378578 0.15342917 0.1085333 0.2420333 0.1335000 4.647119e-03 7.060095e-11 FALSE TRUE
MSTRG.2968.25 ENSG00000117335 HEK293_OSMI2_2hA HEK293_TMG_2hB CD46 protein_coding   30.13586 8.727879 41.69269 0.6822342 1.701613 2.254785 3.567606 0.0000000 4.313690 0.0000000 0.7212572 8.756119 0.07100417 0.0000000 0.1041667 0.1041667 7.060095e-11 7.060095e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117335 E001 0.0000000       1 207752037 207752044 8 +      
ENSG00000117335 E002 0.3666179 0.0306369096 2.825152e-01 4.225191e-01 1 207752045 207752049 5 + 0.062 0.227 2.148
ENSG00000117335 E003 0.3666179 0.0306369096 2.825152e-01 4.225191e-01 1 207752050 207752051 2 + 0.062 0.227 2.148
ENSG00000117335 E004 1.1353558 0.1778039016 5.070880e-01 6.427086e-01 1 207752052 207752053 2 + 0.248 0.378 0.845
ENSG00000117335 E005 1.2826048 0.0347702268 6.570420e-01 7.664875e-01 1 207752054 207752056 3 + 0.285 0.375 0.564
ENSG00000117335 E006 2.0126209 0.0983806256 8.423894e-01 9.017912e-01 1 207752057 207752060 4 + 0.431 0.376 -0.300
ENSG00000117335 E007 6.6189349 0.0256257880 4.129969e-02 9.342992e-02 1 207752061 207752067 7 + 0.866 0.485 -1.623
ENSG00000117335 E008 14.7388729 0.0045479318 2.862991e-01 4.267019e-01 1 207752068 207752097 30 + 1.141 1.024 -0.423
ENSG00000117335 E009 30.7259699 0.0012184857 3.859192e-01 5.301258e-01 1 207752098 207752114 17 + 1.434 1.372 -0.213
ENSG00000117335 E010 34.4109984 0.0026134746 1.573128e-01 2.715309e-01 1 207752115 207752122 8 + 1.489 1.385 -0.362
ENSG00000117335 E011 125.2126628 0.0101714912 1.042397e-01 1.969475e-01 1 207752123 207752309 187 + 2.037 1.935 -0.342
ENSG00000117335 E012 0.6319842 0.0321246654 7.449330e-01 8.331040e-01 1 207756991 207757013 23 + 0.166 0.226 0.559
ENSG00000117335 E013 199.2888698 0.0018814899 4.491324e-03 1.451844e-02 1 207757014 207757202 189 + 2.237 2.135 -0.343
ENSG00000117335 E014 159.8537280 0.0002083124 1.692902e-03 6.260180e-03 1 207757540 207757642 103 + 2.143 2.038 -0.353
ENSG00000117335 E015 136.4609333 0.0005830188 1.119147e-01 2.083776e-01 1 207759639 207759724 86 + 2.064 2.010 -0.184
ENSG00000117335 E016 18.7270270 0.0130407335 5.097662e-03 1.619712e-02 1 207759725 207760984 1260 + 1.271 0.929 -1.237
ENSG00000117335 E017 5.6937618 0.0027879560 6.059654e-02 1.276359e-01 1 207760985 207761248 264 + 0.807 0.485 -1.400
ENSG00000117335 E018 228.6947244 0.0001764878 1.300059e-01 2.341771e-01 1 207761249 207761446 198 + 2.284 2.248 -0.122
ENSG00000117335 E019 244.1364673 0.0002140054 2.330708e-01 3.660637e-01 1 207767013 207767195 183 + 2.309 2.283 -0.087
ENSG00000117335 E020 21.1430105 0.0009717319 2.201583e-02 5.571065e-02 1 207767196 207767606 411 + 1.302 1.077 -0.798
ENSG00000117335 E021 12.6123430 0.0092485596 6.567936e-02 1.361814e-01 1 207767607 207767651 45 + 1.096 0.855 -0.896
ENSG00000117335 E022 12.3517671 0.0016807695 2.416419e-01 3.761170e-01 1 207767652 207767778 127 + 1.067 0.931 -0.504
ENSG00000117335 E023 93.3120275 0.0022662242 4.039844e-02 9.175045e-02 1 207767779 207767823 45 + 1.907 1.807 -0.338
ENSG00000117335 E024 41.1753511 0.0005973630 2.060365e-03 7.412689e-03 1 207767824 207768772 949 + 1.581 1.360 -0.763
ENSG00000117335 E025 35.0206463 0.0005992268 9.328323e-05 4.904457e-04 1 207768773 207769633 861 + 1.527 1.205 -1.118
ENSG00000117335 E026 14.6138002 0.0013197605 2.686103e-01 4.070895e-01 1 207769634 207769947 314 + 1.141 1.024 -0.424
ENSG00000117335 E027 6.0550056 0.0028368051 8.441411e-01 9.029721e-01 1 207769948 207769985 38 + 0.786 0.763 -0.093
ENSG00000117335 E028 6.2022415 0.0026184779 7.848455e-01 8.620414e-01 1 207769986 207770040 55 + 0.797 0.762 -0.136
ENSG00000117335 E029 7.1276797 0.0024236762 4.931405e-01 6.301831e-01 1 207770041 207770123 83 + 0.857 0.763 -0.371
ENSG00000117335 E030 10.8297738 0.0015469166 8.046303e-02 1.602831e-01 1 207770124 207770309 186 + 1.038 0.811 -0.856
ENSG00000117335 E031 6.3709243 0.0050707564 2.414468e-01 3.758761e-01 1 207770310 207770320 11 + 0.828 0.645 -0.744
ENSG00000117335 E032 135.5580810 0.0008471066 2.597305e-01 3.971875e-01 1 207770321 207770338 18 + 2.057 2.019 -0.128
ENSG00000117335 E033 135.4276955 0.0002722888 3.457472e-01 4.898862e-01 1 207770339 207770362 24 + 2.055 2.027 -0.095
ENSG00000117335 E034 0.0000000       1 207775610 207775745 136 +      
ENSG00000117335 E035 0.5546650 0.0240864446 6.911570e-02 1.419116e-01 1 207782731 207782769 39 + 0.063 0.375 3.147
ENSG00000117335 E036 0.5546650 0.0240864446 6.911570e-02 1.419116e-01 1 207782770 207782837 68 + 0.063 0.375 3.147
ENSG00000117335 E037 0.2214452 0.0397585959 9.423036e-02   1 207782838 207782848 11 + 0.000 0.227 10.775
ENSG00000117335 E038 1.4747915 0.0102319903 3.030971e-01 4.450020e-01 1 207782849 207783291 443 + 0.285 0.485 1.146
ENSG00000117335 E039 145.8267737 0.0002128903 1.207486e-01 2.210309e-01 1 207783292 207783330 39 + 2.093 2.043 -0.165
ENSG00000117335 E040 13.7120038 0.0070019980 5.204506e-01 6.544044e-01 1 207783331 207785070 1740 + 1.068 1.146 0.284
ENSG00000117335 E041 145.8225757 0.0002067855 3.971391e-04 1.763349e-03 1 207785071 207785106 36 + 2.107 1.980 -0.427
ENSG00000117335 E042 1.6909407 0.0101877372 9.633356e-01 9.808509e-01 1 207785107 207785618 512 + 0.379 0.374 -0.025
ENSG00000117335 E043 138.1197001 0.0002304570 1.023516e-02 2.934441e-02 1 207785619 207785655 37 + 2.077 1.986 -0.306
ENSG00000117335 E044 144.9275313 0.0002530041 1.359455e-01 2.424087e-01 1 207785656 207785682 27 + 2.090 2.043 -0.158
ENSG00000117335 E045 12.6362805 0.0015073460 7.357221e-04 3.027901e-03 1 207785683 207788337 2655 + 1.122 0.646 -1.838
ENSG00000117335 E046 82.9857421 0.0003302173 1.631613e-03 6.062173e-03 1 207790253 207790324 72 + 1.871 1.718 -0.516
ENSG00000117335 E047 37.0584259 0.0006206726 9.733686e-02 1.864132e-01 1 207790325 207790345 21 + 1.523 1.409 -0.394
ENSG00000117335 E048 17.0535326 0.0058595556 3.797137e-01 5.239645e-01 1 207790346 207792273 1928 + 1.192 1.102 -0.322
ENSG00000117335 E049 169.1934892 0.0002333699 6.364560e-01 7.504820e-01 1 207793519 207793608 90 + 2.149 2.141 -0.027
ENSG00000117335 E050 918.2282604 0.0004894478 5.848618e-17 2.585772e-15 1 207793609 207795004 1396 + 2.848 2.976 0.426
ENSG00000117335 E051 229.9056368 0.0003465468 3.533369e-40 1.239604e-37 1 207795005 207795513 509 + 2.179 2.528 1.165