ENSG00000117298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374893 ENSG00000117298 HEK293_OSMI2_2hA HEK293_TMG_2hB ECE1 protein_coding protein_coding 24.9314 27.13185 23.10735 1.315484 0.4150758 -0.2315435 3.7116545 9.27654190 2.009255 1.31343414 0.1131407 -2.2013184 0.14220417 0.347366667 0.08710000 -0.26026667 2.959740e-05 3.062364e-07 FALSE TRUE
ENST00000415912 ENSG00000117298 HEK293_OSMI2_2hA HEK293_TMG_2hB ECE1 protein_coding protein_coding 24.9314 27.13185 23.10735 1.315484 0.4150758 -0.2315435 17.7811424 17.19888348 15.162035 2.45649269 0.3968757 -0.1817389 0.71471250 0.628266667 0.65656667 0.02830000 9.153653e-01 3.062364e-07 FALSE TRUE
ENST00000436918 ENSG00000117298 HEK293_OSMI2_2hA HEK293_TMG_2hB ECE1 protein_coding protein_coding 24.9314 27.13185 23.10735 1.315484 0.4150758 -0.2315435 0.5127551 0.04615588 1.617309 0.02493238 0.8159427 4.8569070 0.02232500 0.001766667 0.06923333 0.06746667 3.483274e-01 3.062364e-07 FALSE TRUE
MSTRG.485.5 ENSG00000117298 HEK293_OSMI2_2hA HEK293_TMG_2hB ECE1 protein_coding   24.9314 27.13185 23.10735 1.315484 0.4150758 -0.2315435 1.2087093 0.15529003 2.430365 0.07782897 0.2455352 3.8840255 0.05009167 0.005900000 0.10530000 0.09940000 3.062364e-07 3.062364e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117298 E001 0.4481018 0.1624076845 8.105192e-01 8.797636e-01 1 21217247 21217249 3 - 0.134 0.197 0.665
ENSG00000117298 E002 22.8146673 0.0044270996 2.419431e-04 1.141433e-03 1 21217250 21217280 31 - 1.124 1.480 1.247
ENSG00000117298 E003 611.4403713 0.0073530680 9.484203e-15 3.127509e-13 1 21217281 21217978 698 - 2.511 2.894 1.276
ENSG00000117298 E004 633.7964466 0.0035043345 1.369291e-15 5.086435e-14 1 21217979 21218583 605 - 2.591 2.890 0.994
ENSG00000117298 E005 899.2522602 0.0010134600 1.872204e-09 2.637051e-08 1 21218584 21219813 1230 - 2.842 3.001 0.529
ENSG00000117298 E006 171.4525428 0.0003057660 2.705217e-01 4.091811e-01 1 21219814 21219893 80 - 2.174 2.255 0.269
ENSG00000117298 E007 156.1426998 0.0005939819 8.822897e-01 9.286364e-01 1 21219894 21219936 43 - 2.152 2.206 0.180
ENSG00000117298 E008 123.9242212 0.0002525018 9.522295e-01 9.740975e-01 1 21219937 21219958 22 - 2.058 2.105 0.157
ENSG00000117298 E009 241.5171102 0.0005741188 3.830414e-01 5.271970e-01 1 21219959 21220131 173 - 2.328 2.400 0.239
ENSG00000117298 E010 166.0241290 0.0027872153 2.813861e-02 6.828724e-02 1 21221747 21221842 96 - 2.124 2.259 0.450
ENSG00000117298 E011 3.1408774 0.0048127378 1.680829e-01 2.857009e-01 1 21221843 21222081 239 - 0.697 0.524 -0.766
ENSG00000117298 E012 275.7535868 0.0020523929 3.320137e-01 4.756392e-01 1 21225250 21225440 191 - 2.416 2.438 0.074
ENSG00000117298 E013 176.0273793 0.0015699325 1.128297e-01 2.096693e-01 1 21227159 21227226 68 - 2.236 2.235 -0.004
ENSG00000117298 E014 215.0377449 0.0004479902 6.171954e-02 1.295218e-01 1 21227931 21228041 111 - 2.322 2.323 0.004
ENSG00000117298 E015 2.9024037 0.0132069940 8.072201e-01 8.775503e-01 1 21233105 21233557 453 - 0.548 0.624 0.342
ENSG00000117298 E016 110.5593528 0.0008393669 7.934640e-03 2.361366e-02 1 21233558 21233569 12 - 2.064 2.017 -0.155
ENSG00000117298 E017 165.5854844 0.0006274264 3.630686e-02 8.416615e-02 1 21233570 21233661 92 - 2.218 2.206 -0.043
ENSG00000117298 E018 164.8499797 0.0004368585 9.596783e-02 1.843354e-01 1 21235850 21235927 78 - 2.208 2.209 0.003
ENSG00000117298 E019 208.7817724 0.0011885411 2.731639e-05 1.640828e-04 1 21236746 21236844 99 - 2.352 2.280 -0.241
ENSG00000117298 E020 113.0902669 0.0009934163 2.984925e-03 1.021893e-02 1 21238134 21238148 15 - 2.078 2.020 -0.195
ENSG00000117298 E021 189.9096125 0.0010139069 2.735857e-06 2.066504e-05 1 21238149 21238244 96 - 2.319 2.231 -0.295
ENSG00000117298 E022 1.2899917 0.0135885746 2.502332e-01 3.862116e-01 1 21238245 21238350 106 - 0.449 0.274 -1.044
ENSG00000117298 E023 227.3804588 0.0022651938 8.369906e-08 8.629477e-07 1 21244989 21245103 115 - 2.416 2.294 -0.408
ENSG00000117298 E024 207.0711517 0.0005155971 1.549043e-09 2.217649e-08 1 21247221 21247363 143 - 2.368 2.258 -0.367
ENSG00000117298 E025 200.2273738 0.0006965872 1.169941e-08 1.424799e-07 1 21255947 21256138 192 - 2.352 2.245 -0.359
ENSG00000117298 E026 0.0000000       1 21256688 21256717 30 -      
ENSG00000117298 E027 121.4645990 0.0002753557 8.051265e-04 3.277229e-03 1 21257525 21257590 66 - 2.112 2.052 -0.201
ENSG00000117298 E028 152.7259762 0.0017690482 2.363423e-04 1.118100e-03 1 21258693 21258839 147 - 2.220 2.143 -0.259
ENSG00000117298 E029 102.1386371 0.0006019021 1.187957e-04 6.083550e-04 1 21260271 21260312 42 - 2.053 1.961 -0.306
ENSG00000117298 E030 133.2020187 0.0002536525 1.958218e-10 3.285613e-09 1 21260313 21260392 80 - 2.198 2.050 -0.495
ENSG00000117298 E031 116.9046522 0.0002537631 1.969338e-14 6.208772e-13 1 21272699 21272745 47 - 2.169 1.967 -0.679
ENSG00000117298 E032 142.2193301 0.0002451507 6.871351e-15 2.322492e-13 1 21272746 21272831 86 - 2.244 2.060 -0.616
ENSG00000117298 E033 71.1884031 0.0003852492 3.798379e-05 2.201257e-04 1 21272832 21272834 3 - 1.916 1.791 -0.420
ENSG00000117298 E034 112.8386163 0.0002660397 2.385363e-08 2.739451e-07 1 21272835 21272911 77 - 2.123 1.985 -0.462
ENSG00000117298 E035 117.9041491 0.0002918172 4.444764e-06 3.201092e-05 1 21279191 21279332 142 - 2.122 2.020 -0.343
ENSG00000117298 E036 0.5181333 0.0207620993 3.951303e-01 5.389646e-01 1 21279333 21279549 217 - 0.237 0.112 -1.306
ENSG00000117298 E037 0.0000000       1 21279831 21280069 239 -      
ENSG00000117298 E038 86.7965844 0.0003649128 6.934447e-04 2.875080e-03 1 21290070 21290156 87 - 1.978 1.897 -0.274
ENSG00000117298 E039 1.2845899 0.0107515731 1.152133e-02 3.239745e-02 1 21290157 21290257 101 - 0.000 0.484 12.303
ENSG00000117298 E040 4.7522583 0.0322421633 5.293401e-01 6.621408e-01 1 21290364 21290464 101 - 0.783 0.732 -0.208
ENSG00000117298 E041 0.0000000       1 21294154 21294424 271 -      
ENSG00000117298 E042 0.1482932 0.0420742488 6.514601e-01   1 21298817 21298999 183 - 0.000 0.111 8.913
ENSG00000117298 E043 0.6759915 0.5343066631 4.331338e-01 5.755764e-01 1 21344937 21345375 439 - 0.321 0.115 -1.856
ENSG00000117298 E044 62.3821851 0.0097553597 5.239761e-02 1.134284e-01 1 21345376 21345572 197 - 1.832 1.761 -0.243