ENSG00000117280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000235932 ENSG00000117280 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB29 protein_coding protein_coding 9.254337 6.686725 12.40797 0.8208713 0.4648885 0.8909018 0.6223855 0.1632360 1.301364 0.02533673 0.46898034 2.9202575 0.05536667 0.02563333 0.10656667 0.08093333 0.1084316085 0.0001225473 FALSE TRUE
ENST00000367139 ENSG00000117280 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB29 protein_coding protein_coding 9.254337 6.686725 12.40797 0.8208713 0.4648885 0.8909018 6.1379921 5.4418321 7.016133 0.61942299 0.41060690 0.3659898 0.69311250 0.81783333 0.56463333 -0.25320000 0.0001225473 0.0001225473 FALSE TRUE
ENST00000414729 ENSG00000117280 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB29 protein_coding protein_coding 9.254337 6.686725 12.40797 0.8208713 0.4648885 0.8909018 0.6839765 0.3753395 1.061349 0.08961158 0.08228109 1.4752272 0.07125417 0.05450000 0.08626667 0.03176667 0.3128028454 0.0001225473 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117280 E001 73.595988 0.0048050747 1.158947e-09 1.697009e-08 1 205767986 205768239 254 - 1.693 2.037 1.160
ENSG00000117280 E002 75.781806 0.0005297990 1.381078e-13 3.847664e-12 1 205768240 205768312 73 - 1.718 2.045 1.103
ENSG00000117280 E003 265.688779 0.0056885506 9.829798e-08 9.994771e-07 1 205768313 205769436 1124 - 2.319 2.531 0.706
ENSG00000117280 E004 24.849515 0.0009377484 6.730554e-01 7.788481e-01 1 205769437 205769446 10 - 1.416 1.417 0.001
ENSG00000117280 E005 81.882782 0.0004456629 3.839702e-01 5.281762e-01 1 205769447 205769702 256 - 1.923 1.920 -0.011
ENSG00000117280 E006 28.746940 0.0010360769 2.690085e-01 4.074714e-01 1 205769703 205769717 15 - 1.492 1.449 -0.147
ENSG00000117280 E007 83.332454 0.0016634110 7.911321e-01 8.664260e-01 1 205769718 205770002 285 - 1.921 1.940 0.064
ENSG00000117280 E008 68.229006 0.0022916649 3.367173e-03 1.134288e-02 1 205770003 205770095 93 - 1.885 1.773 -0.380
ENSG00000117280 E009 62.007293 0.0131829725 3.067406e-01 4.489214e-01 1 205770096 205770160 65 - 1.820 1.764 -0.191
ENSG00000117280 E010 48.468637 0.0012532933 1.169698e-02 3.281200e-02 1 205770161 205770189 29 - 1.735 1.631 -0.353
ENSG00000117280 E011 72.084977 0.0004027627 2.434014e-02 6.051639e-02 1 205770190 205770299 110 - 1.890 1.826 -0.214
ENSG00000117280 E012 63.654334 0.0004015122 2.272548e-01 3.591199e-01 1 205770300 205770453 154 - 1.822 1.799 -0.076
ENSG00000117280 E013 55.276512 0.0004491724 5.525615e-02 1.184323e-01 1 205770733 205770854 122 - 1.777 1.716 -0.204
ENSG00000117280 E014 3.611771 0.0044015612 3.065154e-01 4.487063e-01 1 205771062 205771471 410 - 0.714 0.584 -0.560
ENSG00000117280 E015 52.658503 0.0010943670 9.692241e-03 2.800400e-02 1 205771472 205771597 126 - 1.773 1.673 -0.337
ENSG00000117280 E016 36.592264 0.0083021636 1.133203e-02 3.195814e-02 1 205771598 205771648 51 - 1.639 1.483 -0.533
ENSG00000117280 E017 20.077427 0.0117062412 5.502289e-02 1.180392e-01 1 205771649 205771653 5 - 1.385 1.234 -0.525
ENSG00000117280 E018 28.167823 0.0007639942 7.523984e-05 4.054028e-04 1 205772496 205772567 72 - 1.557 1.319 -0.819
ENSG00000117280 E019 39.203767 0.0010713176 3.906379e-04 1.738598e-03 1 205774833 205774958 126 - 1.677 1.502 -0.597
ENSG00000117280 E020 35.542088 0.0006040832 4.028578e-05 2.320186e-04 1 205774959 205775086 128 - 1.647 1.430 -0.743
ENSG00000117280 E021 9.508906 0.0026817829 3.895154e-04 1.734091e-03 1 205775087 205775091 5 - 1.148 0.768 -1.426
ENSG00000117280 E022 6.993792 0.0024722339 2.248839e-02 5.669969e-02 1 205775092 205775128 37 - 0.995 0.737 -0.995
ENSG00000117280 E023 10.147983 0.0052162395 3.757980e-01 5.202028e-01 1 205775129 205775272 144 - 1.078 1.013 -0.238
ENSG00000117280 E024 14.407684 0.0014930767 2.851308e-01 4.254359e-01 1 205775273 205775373 101 - 1.222 1.157 -0.231
ENSG00000117280 E025 16.163470 0.0011407182 2.199565e-01 3.503662e-01 1 205775374 205775401 28 - 1.267 1.193 -0.264
ENSG00000117280 E026 16.468578 0.0011540890 9.750253e-02 1.866719e-01 1 205775402 205775482 81 - 1.291 1.181 -0.389