ENSG00000117262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313835 ENSG00000117262 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR89A protein_coding protein_coding 29.89047 15.82613 44.58333 1.936991 2.112489 1.493608 15.915049 11.490270 21.428734 2.2189101 2.0447400 0.8985519 0.55535417 0.71393333 0.48283333 -0.2311000 4.415777e-02 3.260094e-19 FALSE TRUE
ENST00000460277 ENSG00000117262 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR89A protein_coding nonsense_mediated_decay 29.89047 15.82613 44.58333 1.936991 2.112489 1.493608 2.974645 1.648314 2.741751 0.4953091 1.4060381 0.7306327 0.10982500 0.09983333 0.06203333 -0.0378000 7.624087e-01 3.260094e-19 FALSE TRUE
ENST00000462900 ENSG00000117262 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR89A protein_coding protein_coding 29.89047 15.82613 44.58333 1.936991 2.112489 1.493608 3.055138 0.000000 3.345196 0.0000000 2.2826699 8.3902533 0.08122500 0.00000000 0.07320000 0.0732000 3.050026e-01 3.260094e-19 FALSE TRUE
MSTRG.2007.9 ENSG00000117262 HEK293_OSMI2_2hA HEK293_TMG_2hB GPR89A protein_coding   29.89047 15.82613 44.58333 1.936991 2.112489 1.493608 1.312230 0.000000 6.309157 0.0000000 0.9026913 9.3035884 0.02921667 0.00000000 0.14223333 0.1422333 3.260094e-19 3.260094e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117262 E001 0.8878743 0.0131492116 5.058893e-02 1.102018e-01 1 145607988 145607989 2 + 0.384 0.000 -11.430
ENSG00000117262 E002 3.4847844 0.0275973870 1.234676e-01 2.248942e-01 1 145607990 145608013 24 + 0.721 0.447 -1.246
ENSG00000117262 E003 3.9244552 0.0047040810 4.097327e-02 9.283116e-02 1 145608014 145608018 5 + 0.776 0.446 -1.473
ENSG00000117262 E004 4.5155396 0.0036043479 1.057110e-01 1.991748e-01 1 145608019 145608026 8 + 0.809 0.566 -1.020
ENSG00000117262 E005 7.8517293 0.0115537424 2.898679e-02 6.997897e-02 1 145608027 145608032 6 + 1.030 0.738 -1.119
ENSG00000117262 E006 17.2386770 0.0014386476 1.389923e-01 2.467086e-01 1 145608033 145608047 15 + 1.300 1.172 -0.450
ENSG00000117262 E007 106.7248053 0.0003251311 1.814076e-04 8.839964e-04 1 145608048 145608175 128 + 2.072 1.943 -0.431
ENSG00000117262 E008 0.9222159 0.2946274282 5.120129e-01 6.469500e-01 1 145608348 145608612 265 + 0.339 0.161 -1.399
ENSG00000117262 E009 0.4439371 0.0215838830 2.483218e-01 3.839567e-01 1 145608613 145608675 63 + 0.233 0.000 -12.777
ENSG00000117262 E010 0.1817044 0.0439287182 2.531915e-01   1 145611466 145611589 124 + 0.000 0.161 11.346
ENSG00000117262 E011 1.0308689 0.0132048996 7.330136e-01 8.243483e-01 1 145612202 145612247 46 + 0.339 0.277 -0.405
ENSG00000117262 E012 74.4119464 0.0003681172 4.328701e-05 2.475875e-04 1 145616234 145616293 60 + 1.931 1.758 -0.581
ENSG00000117262 E013 0.0000000       1 145618299 145618319 21 +      
ENSG00000117262 E014 50.6747243 0.0005303721 8.123248e-02 1.614754e-01 1 145618320 145618423 104 + 1.740 1.651 -0.300
ENSG00000117262 E015 15.2339279 0.0013735609 9.799042e-01 9.914702e-01 1 145623054 145623160 107 + 1.202 1.198 -0.014
ENSG00000117262 E016 0.5870335 0.1163872536 1.730876e-01 2.921969e-01 1 145623161 145623224 64 + 0.289 0.000 -12.773
ENSG00000117262 E017 0.0000000       1 145623593 145623612 20 +      
ENSG00000117262 E018 5.6808939 0.0028537714 8.451130e-01 9.036471e-01 1 145623613 145623714 102 + 0.809 0.833 0.095
ENSG00000117262 E019 0.7727888 0.0270457359 2.610971e-01 3.987205e-01 1 145630687 145630713 27 + 0.168 0.369 1.500
ENSG00000117262 E020 0.8783093 0.0260923088 3.423570e-01 4.863562e-01 1 145630714 145630807 94 + 0.339 0.160 -1.405
ENSG00000117262 E021 1.1782197 0.0108647759 1.925200e-02 4.988283e-02 1 145631664 145631744 81 + 0.461 0.000 -14.043
ENSG00000117262 E022 2.4504924 0.0090399667 4.129045e-01 5.564698e-01 1 145643869 145643978 110 + 0.584 0.445 -0.668
ENSG00000117262 E023 2.6655949 0.0058680229 6.539020e-01 7.642418e-01 1 145643979 145644067 89 + 0.584 0.510 -0.345
ENSG00000117262 E024 10.4798908 0.0184492749 1.115140e-03 4.354079e-03 1 145644086 145645646 1561 + 1.175 0.738 -1.646
ENSG00000117262 E025 6.3309509 0.0043695366 3.547568e-01 4.990779e-01 1 145645647 145645743 97 + 0.896 0.773 -0.480
ENSG00000117262 E026 8.2005125 0.0024226247 7.848404e-01 8.620408e-01 1 145645744 145645928 185 + 0.968 0.935 -0.124
ENSG00000117262 E027 3.5741182 0.0044597673 6.542484e-01 7.644768e-01 1 145646184 145646203 20 + 0.635 0.701 0.280
ENSG00000117262 E028 4.7555575 0.0035427562 8.078580e-01 8.779213e-01 1 145646204 145646243 40 + 0.740 0.772 0.130
ENSG00000117262 E029 2.4273221 0.0080508020 3.393500e-01 4.832549e-01 1 145646244 145646272 29 + 0.461 0.616 0.726
ENSG00000117262 E030 4.2836332 0.1143601894 4.573357e-01 5.976656e-01 1 145646273 145647174 902 + 0.659 0.777 0.488
ENSG00000117262 E031 6.7461905 0.0026314748 4.284048e-01 5.711793e-01 1 145647175 145647267 93 + 0.840 0.935 0.362
ENSG00000117262 E032 3.4259097 0.0439363318 1.756895e-01 2.955784e-01 1 145663329 145663424 96 + 0.527 0.742 0.935
ENSG00000117262 E033 0.9264943 0.0136765352 4.470642e-01 5.884906e-01 1 145665562 145665651 90 + 0.233 0.369 0.916
ENSG00000117262 E034 2.3667432 0.0570367010 9.520821e-01 9.740099e-01 1 145669625 145669690 66 + 0.527 0.561 0.156
ENSG00000117262 E035 25.6522760 0.0179461016 1.619467e-01 2.776600e-01 1 145669834 145670067 234 + 1.370 1.492 0.419
ENSG00000117262 E036 98.5560484 0.0003241153 4.332517e-03 1.407570e-02 1 145670068 145670191 124 + 1.957 2.052 0.320
ENSG00000117262 E037 144.0254553 0.0003409881 6.964827e-04 2.886349e-03 1 145670192 145670323 132 + 2.121 2.213 0.306
ENSG00000117262 E038 89.4646215 0.0004113802 9.048023e-06 6.075642e-05 1 145670324 145670650 327 + 1.888 2.045 0.528
ENSG00000117262 E039 0.8105550 0.0149741812 4.910634e-01 6.283763e-01 1 145671613 145671772 160 + 0.289 0.161 -1.080
ENSG00000117262 E040 1.1050636 0.1391071867 1.342497e-01 2.400650e-01 1 145687649 145687690 42 + 0.168 0.451 1.947