ENSG00000117222

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264515 ENSG00000117222 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP5 protein_coding protein_coding 17.26848 10.03573 24.98629 2.083015 0.2234133 1.315132 8.297308 7.07751265 9.607405 1.22541184 1.4413137 0.4403683 0.53345000 0.719800000 0.3840667 -0.33573333 9.988111e-03 2.715095e-17 FALSE TRUE
ENST00000367164 ENSG00000117222 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP5 protein_coding protein_coding 17.26848 10.03573 24.98629 2.083015 0.2234133 1.315132 4.391373 2.80242554 6.059210 1.11653574 0.8117211 1.1096937 0.26437500 0.267533333 0.2425667 -0.02496667 9.315075e-01 2.715095e-17 FALSE TRUE
MSTRG.2912.3 ENSG00000117222 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP5 protein_coding   17.26848 10.03573 24.98629 2.083015 0.2234133 1.315132 2.006288 0.04799494 4.886636 0.04799494 0.3788091 6.3997199 0.08668333 0.004633333 0.1954667 0.19083333 2.715095e-17 2.715095e-17 TRUE TRUE
MSTRG.2912.4 ENSG00000117222 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP5 protein_coding   17.26848 10.03573 24.98629 2.083015 0.2234133 1.315132 2.316625 0.05165873 4.322864 0.05165873 0.6879570 6.1348717 0.10290000 0.003833333 0.1735000 0.16966667 1.834908e-07 2.715095e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117222 E001 798.69856 0.0044516276 1.904793e-22 1.596713e-20 1 205086142 205088346 2205 - 2.740 3.071 1.100
ENSG00000117222 E002 99.38863 0.0011322599 5.891453e-01 7.122370e-01 1 205088347 205088446 100 - 1.948 2.047 0.335
ENSG00000117222 E003 200.01293 0.0027667068 4.716666e-01 6.107420e-01 1 205088447 205088812 366 - 2.267 2.311 0.149
ENSG00000117222 E004 52.34951 0.0004482131 6.453350e-01 7.574440e-01 1 205088813 205088815 3 - 1.690 1.747 0.194
ENSG00000117222 E005 88.64780 0.0045029871 8.171462e-01 8.843575e-01 1 205094873 205094986 114 - 1.911 1.970 0.199
ENSG00000117222 E006 107.62883 0.0032480738 8.341420e-01 8.961341e-01 1 205094987 205095064 78 - 1.993 2.059 0.222
ENSG00000117222 E007 153.80369 0.0007213908 1.395050e-02 3.810820e-02 1 205096682 205096852 171 - 2.170 2.171 0.005
ENSG00000117222 E008 75.10533 0.0004977748 4.837468e-01 6.217647e-01 1 205096853 205096911 59 - 1.844 1.894 0.169
ENSG00000117222 E009 87.34903 0.0007676689 3.670775e-02 8.491779e-02 1 205097326 205097395 70 - 1.927 1.921 -0.023
ENSG00000117222 E010 113.17300 0.0078937742 8.779913e-02 1.717888e-01 1 205098989 205099106 118 - 2.045 2.017 -0.096
ENSG00000117222 E011 96.94682 0.0031762261 2.715179e-02 6.630606e-02 1 205099741 205099812 72 - 1.981 1.954 -0.089
ENSG00000117222 E012 142.35761 0.0025874046 4.100564e-03 1.342643e-02 1 205099911 205100064 154 - 2.150 2.116 -0.113
ENSG00000117222 E013 151.79428 0.0002377305 4.898284e-05 2.766494e-04 1 205100152 205100271 120 - 2.180 2.139 -0.139
ENSG00000117222 E014 131.87728 0.0002821593 4.224389e-08 4.624662e-07 1 205101600 205101709 110 - 2.137 2.036 -0.337
ENSG00000117222 E015 170.09126 0.0002695707 4.913163e-09 6.421858e-08 1 205103857 205104019 163 - 2.245 2.157 -0.295
ENSG00000117222 E016 104.80215 0.0004754392 2.138058e-10 3.562434e-09 1 205105028 205105086 59 - 2.057 1.896 -0.541
ENSG00000117222 E017 100.94874 0.0002761265 7.408472e-08 7.716696e-07 1 205105087 205105168 82 - 2.030 1.907 -0.411
ENSG00000117222 E018 128.75241 0.0002829421 7.057079e-08 7.377805e-07 1 205114789 205114961 173 - 2.126 2.026 -0.334
ENSG00000117222 E019 53.50032 0.0004089120 5.143263e-05 2.889048e-04 1 205115858 205115883 26 - 1.758 1.627 -0.442
ENSG00000117222 E020 78.02251 0.0003755774 8.562003e-05 4.545455e-04 1 205121855 205122015 161 - 1.909 1.822 -0.293