ENSG00000117174

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370574 ENSG00000117174 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNHIT6 protein_coding protein_coding 17.91771 7.203459 28.06927 0.2459057 0.1723982 1.960743 8.287365 4.5501283 12.417111 0.1734462 0.5277877 1.446345 0.4975958 0.6339333 0.4421667 -0.19176667 0.005614762 0.005614762 FALSE TRUE
MSTRG.1530.3 ENSG00000117174 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNHIT6 protein_coding   17.91771 7.203459 28.06927 0.2459057 0.1723982 1.960743 2.577342 0.8269782 3.623818 0.2148957 0.3301963 2.118224 0.1588583 0.1170000 0.1290333 0.01203333 0.873978233 0.005614762 FALSE TRUE
MSTRG.1530.4 ENSG00000117174 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNHIT6 protein_coding   17.91771 7.203459 28.06927 0.2459057 0.1723982 1.960743 6.757120 1.8047916 11.215704 0.5941161 0.4375198 2.628930 0.3288958 0.2459333 0.3997333 0.15380000 0.361885566 0.005614762 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117174 E001 0.3666179 0.0299443473 4.630043e-01 6.028589e-01 1 85649417 85649422 6 - 0.075 0.193 1.566
ENSG00000117174 E002 673.5740773 0.0057354047 1.088661e-04 5.628613e-04 1 85649423 85653701 4279 - 2.735 2.894 0.528
ENSG00000117174 E003 106.8192139 0.0030412375 6.360317e-08 6.710532e-07 1 85653702 85653774 73 - 1.894 2.161 0.896
ENSG00000117174 E004 239.0652612 0.0014648131 2.784996e-03 9.629660e-03 1 85653775 85654098 324 - 2.298 2.420 0.407
ENSG00000117174 E005 154.5705032 0.0025004371 8.568498e-01 9.115323e-01 1 85657847 85657971 125 - 2.140 2.167 0.093
ENSG00000117174 E006 1.7820913 0.0081206626 1.211903e-02 3.382163e-02 1 85660041 85660089 49 - 0.515 0.000 -12.034
ENSG00000117174 E007 3.5720153 0.0061657124 3.387706e-01 4.826510e-01 1 85662222 85662274 53 - 0.562 0.739 0.757
ENSG00000117174 E008 2.3616321 0.0184632136 4.791126e-01 6.175135e-01 1 85662275 85662277 3 - 0.432 0.581 0.721
ENSG00000117174 E009 136.6922604 0.0002519719 2.628388e-01 4.006595e-01 1 85677236 85677313 78 - 2.096 2.094 -0.006
ENSG00000117174 E010 120.8093480 0.0002537351 6.548801e-01 7.649272e-01 1 85678701 85678781 81 - 2.037 2.057 0.066
ENSG00000117174 E011 1.1760296 0.0141707675 5.095064e-02 1.108585e-01 1 85679373 85679448 76 - 0.400 0.000 -11.449
ENSG00000117174 E012 93.3792939 0.0011769438 8.894404e-01 9.333271e-01 1 85680836 85680904 69 - 1.922 1.952 0.100
ENSG00000117174 E013 114.8468028 0.0002932357 4.184694e-01 5.617319e-01 1 85702157 85702260 104 - 2.018 2.024 0.020
ENSG00000117174 E014 119.4223719 0.0002452869 6.274484e-01 7.432469e-01 1 85706078 85706163 86 - 2.034 2.053 0.062
ENSG00000117174 E015 122.6833295 0.0002934441 3.617166e-01 5.061275e-01 1 85706249 85706355 107 - 2.049 2.053 0.012
ENSG00000117174 E016 101.4585193 0.0004928469 4.785531e-01 6.169686e-01 1 85706442 85706507 66 - 1.965 1.973 0.026
ENSG00000117174 E017 344.5647133 0.0003210654 4.962744e-10 7.771342e-09 1 85707629 85707936 308 - 2.524 2.422 -0.338
ENSG00000117174 E018 205.7682407 0.0004663394 1.230189e-05 8.004934e-05 1 85707937 85708053 117 - 2.299 2.208 -0.303
ENSG00000117174 E019 264.3471245 0.0001868564 7.499274e-15 2.517659e-13 1 85708054 85708433 380 - 2.423 2.263 -0.532