ENSG00000117153

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367259 ENSG00000117153 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL12 protein_coding protein_coding 21.09723 19.95575 20.27296 3.484912 0.1796009 0.02274108 1.909776 2.73201636 1.820186 0.9006931 0.32611503 -0.58324663 0.09055000 0.136566667 0.08953333 -0.04703333 6.439814e-01 1.764401e-15 FALSE  
ENST00000367261 ENSG00000117153 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL12 protein_coding protein_coding 21.09723 19.95575 20.27296 3.484912 0.1796009 0.02274108 18.167512 16.72827665 17.174561 2.9436434 0.23024739 0.03796201 0.86340000 0.837400000 0.84740000 0.01000000 8.904948e-01 1.764401e-15 FALSE  
MSTRG.2862.4 ENSG00000117153 HEK293_OSMI2_2hA HEK293_TMG_2hB KLHL12 protein_coding   21.09723 19.95575 20.27296 3.484912 0.1796009 0.02274108 0.549172 0.05122643 1.278216 0.0272823 0.06231141 4.39507665 0.02445417 0.002433333 0.06306667 0.06063333 1.764401e-15 1.764401e-15 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117153 E001 2.177673 0.0072438620 8.561495e-02 1.683834e-01 1 202891116 202891119 4 - 0.305 0.615 1.613
ENSG00000117153 E002 639.197162 0.0024381944 4.440366e-09 5.840141e-08 1 202891120 202892266 1147 - 2.714 2.865 0.501
ENSG00000117153 E003 296.186633 0.0030967734 7.840917e-01 8.614982e-01 1 202892267 202892659 393 - 2.457 2.489 0.108
ENSG00000117153 E004 180.736860 0.0002309786 3.368775e-01 4.807348e-01 1 202893239 202893419 181 - 2.266 2.266 0.000
ENSG00000117153 E005 64.316993 0.0035839414 3.600213e-01 5.043328e-01 1 202893420 202893425 6 - 1.779 1.843 0.215
ENSG00000117153 E006 136.244663 0.0012982816 8.289833e-01 8.925909e-01 1 202894184 202894282 99 - 2.134 2.150 0.053
ENSG00000117153 E007 177.900554 0.0003583255 7.500051e-02 1.515328e-01 1 202894591 202894749 159 - 2.272 2.249 -0.077
ENSG00000117153 E008 190.865185 0.0001957695 1.326654e-02 3.654018e-02 1 202895522 202895717 196 - 2.308 2.270 -0.127
ENSG00000117153 E009 147.615543 0.0003693154 3.729611e-02 8.602890e-02 1 202896854 202896960 107 - 2.196 2.159 -0.125
ENSG00000117153 E010 168.491028 0.0002497830 4.527657e-02 1.006998e-01 1 202909010 202909124 115 - 2.250 2.220 -0.100
ENSG00000117153 E011 4.332931 0.0260735357 1.112220e-04 5.733674e-04 1 202909125 202909161 37 - 0.962 0.352 -2.704
ENSG00000117153 E012 181.478494 0.0003864710 1.847975e-01 3.072181e-01 1 202911054 202911203 150 - 2.273 2.261 -0.039
ENSG00000117153 E013 214.711761 0.0014291273 1.447964e-01 2.545516e-01 1 202918171 202918388 218 - 2.350 2.327 -0.077
ENSG00000117153 E014 162.934100 0.0011476286 5.299712e-03 1.674697e-02 1 202919755 202919908 154 - 2.254 2.188 -0.218
ENSG00000117153 E015 187.000049 0.0002583795 6.737726e-03 2.054238e-02 1 202924968 202925207 240 - 2.304 2.258 -0.152
ENSG00000117153 E016 68.142803 0.0026245314 3.996569e-01 5.433947e-01 1 202927089 202927260 172 - 1.855 1.834 -0.069
ENSG00000117153 E017 0.000000       1 202928481 202928636 156 -