ENSG00000117010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372697 ENSG00000117010 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF684 protein_coding protein_coding 3.978544 4.927721 4.359767 0.1970978 0.2474104 -0.1762889 2.0385695 4.0938213 1.3095164 0.14260618 0.40211906 -1.6369586 0.51080417 0.83123333 0.29213333 -0.539100000 1.099057e-07 1.099057e-07 FALSE TRUE
ENST00000372699 ENSG00000117010 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF684 protein_coding protein_coding 3.978544 4.927721 4.359767 0.1970978 0.2474104 -0.1762889 1.4282370 0.2593465 2.6681091 0.13299310 0.08051432 3.3136793 0.35997500 0.05440000 0.61776667 0.563366667 4.679839e-04 1.099057e-07 FALSE TRUE
ENST00000465152 ENSG00000117010 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF684 protein_coding processed_transcript 3.978544 4.927721 4.359767 0.1970978 0.2474104 -0.1762889 0.2177178 0.2105629 0.1456403 0.07211531 0.07517991 -0.5029745 0.05249583 0.04183333 0.03266667 -0.009166667 8.695715e-01 1.099057e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000117010 E001 1.6899059 0.5082065817 6.525042e-01 7.631919e-01 1 40531573 40531636 64 + 0.392 0.439 0.254
ENSG00000117010 E002 3.2870811 0.0064024998 4.589871e-01 5.992222e-01 1 40531637 40531652 16 + 0.704 0.555 -0.649
ENSG00000117010 E003 4.9757656 0.0034101087 4.698615e-01 6.090998e-01 1 40531653 40531662 10 + 0.734 0.790 0.224
ENSG00000117010 E004 21.3058053 0.0009380145 1.575800e-01 2.719006e-01 1 40531663 40531721 59 + 1.297 1.353 0.197
ENSG00000117010 E005 33.9361936 0.0006192339 1.190629e-01 2.186071e-01 1 40531722 40531787 66 + 1.505 1.546 0.142
ENSG00000117010 E006 0.1472490 0.0422310998 4.319896e-01   1 40532733 40532808 76 + 0.136 0.000 -8.604
ENSG00000117010 E007 30.5549576 0.0007524618 1.138268e-01 2.110987e-01 1 40533143 40533181 39 + 1.457 1.505 0.166
ENSG00000117010 E008 56.5193153 0.0004873441 1.690005e-02 4.471411e-02 1 40540586 40540712 127 + 1.709 1.765 0.190
ENSG00000117010 E009 0.6664396 0.5185834928 9.215077e-01 9.544518e-01 1 40541314 40541614 301 + 0.241 0.199 -0.356
ENSG00000117010 E010 54.3082967 0.0068283898 4.797597e-02 1.055963e-01 1 40541615 40541710 96 + 1.696 1.756 0.201
ENSG00000117010 E011 20.4222493 0.0103628111 4.636772e-06 3.326224e-05 1 40544397 40544415 19 + 1.054 1.430 1.328
ENSG00000117010 E012 36.9146465 0.0007144416 6.277521e-12 1.350508e-10 1 40544416 40545037 622 + 1.313 1.677 1.252
ENSG00000117010 E013 62.2772672 0.0102859807 8.766812e-32 1.654229e-29 1 40546562 40548167 1606 + 2.091 1.333 -2.577