ENSG00000116990

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372815 ENSG00000116990 HEK293_OSMI2_2hA HEK293_TMG_2hB MYCL protein_coding protein_coding 2.823798 3.918324 2.176236 0.2399151 0.1381982 -0.8454644 0.5003100 0.7985733 0.2027697 0.09454056 0.01579358 -1.9260857 0.1752917 0.2042000 0.0941000 -0.11010000 0.0427823 0.0427823 FALSE TRUE
ENST00000372816 ENSG00000116990 HEK293_OSMI2_2hA HEK293_TMG_2hB MYCL protein_coding protein_coding 2.823798 3.918324 2.176236 0.2399151 0.1381982 -0.8454644 0.5614946 0.7666658 0.6180934 0.21685306 0.14445934 -0.3063147 0.2030375 0.1936000 0.2785333 0.08493333 0.5541591 0.0427823 FALSE TRUE
ENST00000397332 ENSG00000116990 HEK293_OSMI2_2hA HEK293_TMG_2hB MYCL protein_coding protein_coding 2.823798 3.918324 2.176236 0.2399151 0.1381982 -0.8454644 1.7619929 2.3530845 1.3553731 0.30211167 0.07696058 -0.7913759 0.6216583 0.6021333 0.6273333 0.02520000 0.9582475 0.0427823 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116990 E001 0.5451131 0.5902312543 4.881556e-01 6.257670e-01 1 39895426 39895427 2 - 0.001 0.235 9.128
ENSG00000116990 E002 206.9700026 0.0005574315 7.623018e-01 8.459021e-01 1 39895428 39897970 2543 - 2.283 2.281 -0.006
ENSG00000116990 E003 24.5993065 0.0052199904 5.886482e-06 4.124783e-05 1 39899612 39900938 1327 - 1.053 1.455 1.418
ENSG00000116990 E004 18.0601448 0.0021265761 9.185623e-02 1.780158e-01 1 39900939 39901133 195 - 1.334 1.201 -0.467
ENSG00000116990 E005 25.4293087 0.0058844262 5.031243e-01 6.391044e-01 1 39901134 39901443 310 - 1.416 1.368 -0.168
ENSG00000116990 E006 8.5812768 0.0033605492 1.692376e-01 2.871947e-01 1 39901444 39901807 364 - 1.035 0.883 -0.570
ENSG00000116990 E007 4.4276468 0.0040011339 2.629511e-02 6.454179e-02 1 39901808 39902013 206 - 0.887 0.584 -1.242
ENSG00000116990 E008 0.0000000       1 39902141 39902256 116 -