ENSG00000116984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366576 ENSG00000116984 HEK293_OSMI2_2hA HEK293_TMG_2hB MTR protein_coding protein_coding 16.17194 11.91243 20.3159 1.293311 0.7088803 0.769641 2.4506361 5.27539596 0.2454958 0.22587372 0.2454958 -4.3706401 0.18163750 0.4494333 0.01130000 -0.438133333 1.463531e-03 3.217117e-21 FALSE TRUE
ENST00000366577 ENSG00000116984 HEK293_OSMI2_2hA HEK293_TMG_2hB MTR protein_coding protein_coding 16.17194 11.91243 20.3159 1.293311 0.7088803 0.769641 7.6793927 4.82253329 9.2407985 0.67506352 0.1405042 0.9367982 0.47128750 0.4039333 0.45563333 0.051700000 5.169807e-01 3.217117e-21 FALSE TRUE
ENST00000535889 ENSG00000116984 HEK293_OSMI2_2hA HEK293_TMG_2hB MTR protein_coding protein_coding 16.17194 11.91243 20.3159 1.293311 0.7088803 0.769641 1.1441987 0.07402809 2.4490656 0.03735364 0.4722567 4.8710947 0.05985833 0.0057000 0.11926667 0.113566667 5.623560e-11 3.217117e-21 FALSE TRUE
ENST00000674797 ENSG00000116984 HEK293_OSMI2_2hA HEK293_TMG_2hB MTR protein_coding protein_coding 16.17194 11.91243 20.3159 1.293311 0.7088803 0.769641 0.9223289 0.84655663 1.3105560 0.42794229 0.1036189 0.6245249 0.05441667 0.0662000 0.06493333 -0.001266667 8.859562e-01 3.217117e-21 FALSE TRUE
MSTRG.3345.2 ENSG00000116984 HEK293_OSMI2_2hA HEK293_TMG_2hB MTR protein_coding   16.17194 11.91243 20.3159 1.293311 0.7088803 0.769641 0.9622234 0.00000000 3.2019357 0.00000000 0.2462016 8.3272992 0.04886667 0.0000000 0.15876667 0.158766667 3.217117e-21 3.217117e-21 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116984 E001 1.9302682 0.2185612476 8.869357e-01 9.317044e-01 1 236795260 236795291 32 + 0.438 0.471 0.172
ENSG00000116984 E002 6.8803068 0.0023880099 7.619685e-02 1.534269e-01 1 236795292 236795311 20 + 0.912 0.804 -0.417
ENSG00000116984 E003 13.4439149 0.0013302828 1.710391e-01 2.895348e-01 1 236795312 236795325 14 + 1.140 1.136 -0.014
ENSG00000116984 E004 33.3105625 0.0006144555 4.771450e-04 2.072537e-03 1 236795326 236795386 61 + 1.545 1.452 -0.319
ENSG00000116984 E005 30.0988209 0.0006606533 6.932377e-04 2.874284e-03 1 236795387 236795394 8 + 1.503 1.405 -0.338
ENSG00000116984 E006 39.5657580 0.0005162245 2.116140e-06 1.637180e-05 1 236795395 236795438 44 + 1.635 1.481 -0.525
ENSG00000116984 E007 59.1532923 0.0009352008 5.530457e-10 8.600627e-09 1 236795439 236795614 176 + 1.815 1.628 -0.632
ENSG00000116984 E008 37.5915407 0.0005823004 1.041774e-11 2.162385e-10 1 236795615 236795681 67 + 1.652 1.342 -1.064
ENSG00000116984 E009 34.9018962 0.0005829713 1.393929e-10 2.401560e-09 1 236795682 236795703 22 + 1.619 1.322 -1.021
ENSG00000116984 E010 43.1372511 0.0004916240 1.954867e-16 8.100257e-15 1 236795704 236795737 34 + 1.723 1.342 -1.306
ENSG00000116984 E011 25.4187944 0.0007541964 2.749212e-12 6.283386e-11 1 236803428 236803430 3 + 1.512 1.069 -1.552
ENSG00000116984 E012 100.0516768 0.0003375781 3.188261e-28 4.593205e-26 1 236803431 236803642 212 + 2.071 1.757 -1.058
ENSG00000116984 E013 71.7358876 0.0098061622 7.292541e-10 1.109590e-08 1 236806144 236806233 90 + 1.920 1.639 -0.949
ENSG00000116984 E014 70.8908600 0.0066821178 2.881462e-12 6.559533e-11 1 236808704 236808773 70 + 1.920 1.614 -1.034
ENSG00000116984 E015 2.9094199 0.1953196204 6.159196e-02 1.293085e-01 1 236809462 236810502 1041 + 0.673 0.297 -1.922
ENSG00000116984 E016 75.7525319 0.0005612998 1.836380e-19 1.105136e-17 1 236810503 236810595 93 + 1.945 1.657 -0.971
ENSG00000116984 E017 0.1451727 0.0427804513 7.744215e-01   1 236811645 236811701 57 + 0.085 0.000 -20.955
ENSG00000116984 E018 68.2139326 0.0003777446 6.204219e-09 7.958363e-08 1 236812738 236812844 107 + 1.861 1.726 -0.457
ENSG00000116984 E019 51.3084831 0.0019363472 7.128900e-06 4.898813e-05 1 236815604 236815663 60 + 1.734 1.613 -0.409
ENSG00000116984 E020 70.1399484 0.0007751123 3.200190e-05 1.890912e-04 1 236816449 236816543 95 + 1.849 1.792 -0.192
ENSG00000116984 E021 66.9981552 0.0006588724 3.976157e-06 2.894524e-05 1 236824119 236824219 101 + 1.838 1.757 -0.276
ENSG00000116984 E022 63.5829544 0.0003725019 2.188658e-11 4.313718e-10 1 236825338 236825399 62 + 1.848 1.657 -0.646
ENSG00000116984 E023 74.9667659 0.0010112676 2.004644e-09 2.805243e-08 1 236826829 236826896 68 + 1.903 1.761 -0.481
ENSG00000116984 E024 83.6843447 0.0052837149 1.551364e-07 1.519105e-06 1 236829189 236829268 80 + 1.952 1.801 -0.509
ENSG00000116984 E025 97.5442614 0.0045336168 1.667122e-08 1.972097e-07 1 236831966 236832078 113 + 2.018 1.867 -0.507
ENSG00000116984 E026 81.1202185 0.0177752620 6.360883e-04 2.666512e-03 1 236835547 236835615 69 + 1.930 1.806 -0.416
ENSG00000116984 E027 78.1237122 0.0003220136 6.875108e-10 1.051480e-08 1 236835616 236835687 72 + 1.918 1.785 -0.448
ENSG00000116984 E028 90.2790598 0.0003286188 3.580941e-10 5.757435e-09 1 236838414 236838518 105 + 1.977 1.859 -0.397
ENSG00000116984 E029 93.7797172 0.0002870790 7.465903e-09 9.419239e-08 1 236838519 236838599 81 + 1.985 1.893 -0.309
ENSG00000116984 E030 118.8852129 0.0088043132 3.754574e-07 3.403315e-06 1 236850344 236850523 180 + 2.104 1.952 -0.510
ENSG00000116984 E031 92.9398809 0.0011975820 1.333771e-09 1.931501e-08 1 236852521 236852637 117 + 1.988 1.865 -0.414
ENSG00000116984 E032 106.2248437 0.0003148974 7.400058e-12 1.573422e-10 1 236852948 236853088 141 + 2.046 1.924 -0.408
ENSG00000116984 E033 95.4254141 0.0005358949 1.027549e-08 1.263819e-07 1 236859833 236859922 90 + 1.993 1.901 -0.311
ENSG00000116984 E034 102.8473555 0.0033458201 1.068340e-04 5.535332e-04 1 236861125 236861277 153 + 2.010 1.968 -0.141
ENSG00000116984 E035 87.7402425 0.0043570580 3.611707e-03 1.204307e-02 1 236862236 236862343 108 + 1.931 1.918 -0.047
ENSG00000116984 E036 82.2086628 0.0008677838 1.703440e-04 8.365391e-04 1 236863454 236863554 101 + 1.910 1.884 -0.087
ENSG00000116984 E037 66.8630868 0.0004027860 1.348529e-02 3.704654e-02 1 236873773 236873840 68 + 1.803 1.825 0.075
ENSG00000116984 E038 99.6082043 0.0003113486 1.913174e-03 6.956586e-03 1 236874726 236874846 121 + 1.975 1.994 0.064
ENSG00000116984 E039 101.3033888 0.0002704262 6.834791e-04 2.838607e-03 1 236880755 236880836 82 + 1.985 1.994 0.031
ENSG00000116984 E040 108.5940771 0.0002939983 1.904982e-03 6.930654e-03 1 236885121 236885219 99 + 2.009 2.033 0.079
ENSG00000116984 E041 88.6616698 0.0003064860 2.302305e-03 8.157950e-03 1 236886292 236886367 76 + 1.925 1.939 0.047
ENSG00000116984 E042 8.8872552 0.0226821477 3.478383e-02 8.123188e-02 1 236886368 236889180 2813 + 0.808 1.191 1.422
ENSG00000116984 E043 117.2785668 0.0027758586 1.750632e-02 4.605702e-02 1 236889181 236889336 156 + 2.036 2.071 0.118
ENSG00000116984 E044 85.0886230 0.0015227571 6.192103e-02 1.298511e-01 1 236891133 236891222 90 + 1.894 1.947 0.179
ENSG00000116984 E045 90.4267388 0.0002995621 4.538638e-02 1.009022e-01 1 236891223 236891329 107 + 1.919 1.976 0.191
ENSG00000116984 E046 15.4808815 0.0095215070 5.715895e-01 6.978354e-01 1 236891330 236894356 3027 + 1.173 1.245 0.255
ENSG00000116984 E047 147.0014070 0.0002201730 1.965706e-02 5.075465e-02 1 236894357 236894557 201 + 2.125 2.188 0.213
ENSG00000116984 E048 7.6456571 0.0045145675 8.960084e-01 9.375337e-01 1 236894558 236895357 800 + 0.876 1.011 0.507
ENSG00000116984 E049 130.8238535 0.0021969866 3.923821e-02 8.961928e-02 1 236895358 236895550 193 + 2.077 2.131 0.183
ENSG00000116984 E050 117.2024049 0.0002895007 2.303066e-02 5.781377e-02 1 236897006 236897118 113 + 2.028 2.085 0.189
ENSG00000116984 E051 272.1709666 0.0009344058 4.934950e-01 6.305168e-01 1 236897558 236898003 446 + 2.369 2.488 0.396
ENSG00000116984 E052 288.9012810 0.0032868786 9.316196e-02 1.800687e-01 1 236898004 236898522 519 + 2.360 2.558 0.660
ENSG00000116984 E053 324.4574545 0.0001984812 5.064099e-10 7.916970e-09 1 236898523 236899109 587 + 2.381 2.641 0.869
ENSG00000116984 E054 1665.4596696 0.0088187765 2.227855e-25 2.521269e-23 1 236899110 236903778 4669 + 2.959 3.455 1.649
ENSG00000116984 E055 66.3448169 0.0122000983 2.753004e-19 1.620722e-17 1 236903779 236903981 203 + 1.376 2.147 2.611
ENSG00000116984 E056 3.5158141 0.0182792470 4.866404e-01 6.243529e-01 1 236907045 236907206 162 + 0.557 0.768 0.902
ENSG00000116984 E057 4.4682084 0.0255098203 4.923032e-01 6.294870e-01 1 236913298 236913424 127 + 0.728 0.730 0.010
ENSG00000116984 E058 1.4767686 0.2808302881 4.126068e-01 5.561657e-01 1 236913425 236913430 6 + 0.437 0.290 -0.871
ENSG00000116984 E059 4.5155501 0.0038215967 5.420939e-01 6.729266e-01 1 236916741 236916920 180 + 0.710 0.732 0.091
ENSG00000116984 E060 5.8375916 0.0084853143 6.444585e-01 7.567492e-01 1 236920811 236921278 468 + 0.745 0.920 0.683