ENSG00000116962

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264187 ENSG00000116962 HEK293_OSMI2_2hA HEK293_TMG_2hB NID1 protein_coding protein_coding 30.94076 32.85756 29.26851 2.945056 0.5847532 -0.1668221 26.224306 27.003844 24.5732203 3.1940311 0.68756311 -0.136025 0.8458542 0.8172000 0.8394333 0.02223333 8.133307e-01 2.738392e-11 FALSE TRUE
ENST00000366595 ENSG00000116962 HEK293_OSMI2_2hA HEK293_TMG_2hB NID1 protein_coding protein_coding 30.94076 32.85756 29.26851 2.945056 0.5847532 -0.1668221 1.927094 5.130044 0.5443439 0.4940353 0.02944139 -3.212928 0.0633250 0.1612667 0.0186000 -0.14266667 2.738392e-11 2.738392e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116962 E001 762.2097 0.0066070983 1.441004e-25 1.672757e-23 1 235975830 235976361 532 - 2.542 3.018 1.582
ENSG00000116962 E002 325.5310 0.0006948319 5.401110e-59 5.357194e-56 1 235976362 235976415 54 - 2.184 2.643 1.530
ENSG00000116962 E003 275.1032 0.0022691293 2.480448e-28 3.620289e-26 1 235976416 235976435 20 - 2.147 2.563 1.386
ENSG00000116962 E004 292.5979 0.0037750869 1.613835e-19 9.755463e-18 1 235976436 235976454 19 - 2.194 2.584 1.301
ENSG00000116962 E005 1523.4809 0.0046613767 6.636344e-10 1.017897e-08 1 235976455 235977587 1133 - 3.024 3.260 0.787
ENSG00000116962 E006 495.4930 0.0012219630 5.798500e-01 7.046920e-01 1 235977588 235977988 401 - 2.666 2.702 0.121
ENSG00000116962 E007 247.3781 0.0001726731 5.815364e-03 1.812668e-02 1 235978995 235979107 113 - 2.395 2.378 -0.058
ENSG00000116962 E008 274.1140 0.0002682636 1.592376e-02 4.256078e-02 1 235979822 235979945 124 - 2.435 2.427 -0.025
ENSG00000116962 E009 295.4506 0.0001773934 1.129652e-03 4.403392e-03 1 235980496 235980653 158 - 2.474 2.452 -0.076
ENSG00000116962 E010 281.6742 0.0017956374 6.437190e-03 1.975869e-02 1 235981611 235981782 172 - 2.458 2.429 -0.098
ENSG00000116962 E011 249.9298 0.0008499924 4.674670e-06 3.350239e-05 1 235985379 235985505 127 - 2.430 2.358 -0.240
ENSG00000116962 E012 257.7547 0.0013643523 1.531185e-06 1.221743e-05 1 235990886 235991058 173 - 2.451 2.364 -0.288
ENSG00000116962 E013 259.3584 0.0015988756 1.222682e-05 7.960186e-05 1 235993645 235993872 228 - 2.450 2.371 -0.262
ENSG00000116962 E014 217.8723 0.0018770504 9.663252e-07 8.040679e-06 1 236011921 236012037 117 - 2.389 2.283 -0.356
ENSG00000116962 E015 116.4058 0.0037088471 3.757541e-04 1.680409e-03 1 236012038 236012043 6 - 2.122 2.012 -0.368
ENSG00000116962 E016 206.9979 0.0014586649 1.957056e-06 1.525566e-05 1 236013411 236013560 150 - 2.362 2.265 -0.322
ENSG00000116962 E017 195.1599 0.0007961726 1.952516e-09 2.739428e-08 1 236017148 236017273 126 - 2.349 2.226 -0.411
ENSG00000116962 E018 211.5127 0.0004716580 8.274891e-09 1.035643e-07 1 236024070 236024213 144 - 2.375 2.272 -0.345
ENSG00000116962 E019 283.4086 0.0034138149 9.543611e-09 1.181550e-07 1 236025896 236026141 246 - 2.524 2.377 -0.492
ENSG00000116962 E020 249.5666 0.0025471562 1.617099e-11 3.253207e-10 1 236029550 236029750 201 - 2.482 2.311 -0.569
ENSG00000116962 E021 273.6786 0.0055018877 3.871643e-06 2.826152e-05 1 236032401 236032652 252 - 2.506 2.368 -0.460
ENSG00000116962 E022 184.0273 0.0140921180 2.282242e-03 8.096701e-03 1 236038104 236038253 150 - 2.336 2.196 -0.466
ENSG00000116962 E023 350.5973 0.0053943071 2.012783e-08 2.345837e-07 1 236041910 236042292 383 - 2.628 2.460 -0.560
ENSG00000116962 E024 288.6215 0.0021085517 1.472208e-21 1.118305e-19 1 236045457 236045683 227 - 2.575 2.337 -0.791
ENSG00000116962 E025 304.7013 0.0030021514 1.334575e-15 4.969167e-14 1 236048690 236048989 300 - 2.588 2.375 -0.709
ENSG00000116962 E026 183.4358 0.0066056602 7.934378e-07 6.734818e-06 1 236064855 236065185 331 - 2.353 2.173 -0.601