ENSG00000116922

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358011 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding protein_coding 32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 7.3488118 8.1832960 8.0466525 2.7168943 0.6620996 -0.02426342 0.24600833 0.34143333 0.17793333 -0.16350000 6.256622e-02 8.704957e-20 FALSE  
ENST00000461359 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding protein_coding 32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 0.7677285 1.7204768 0.4836396 1.1546745 0.4836396 -1.80963946 0.03241667 0.06476667 0.01090000 -0.05386667 4.256286e-01 8.704957e-20 FALSE  
ENST00000464178 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding processed_transcript 32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 5.5400557 2.3320497 8.7239267 0.4066960 0.7807399 1.89885874 0.14772500 0.10886667 0.19166667 0.08280000 1.491553e-01 8.704957e-20 FALSE  
ENST00000472584 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding processed_transcript 32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 1.2439653 0.0000000 2.3408367 0.0000000 0.2089900 7.87703053 0.03381250 0.00000000 0.05146667 0.05146667 8.704957e-20 8.704957e-20 TRUE  
ENST00000486637 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding protein_coding 32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 8.0143814 5.2995724 12.3530647 0.3072825 1.0048973 1.21936883 0.23907083 0.23986667 0.27180000 0.03193333 7.016099e-01 8.704957e-20 FALSE  
ENST00000491797 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding processed_transcript 32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 2.0716474 1.1390618 0.8547062 0.7202823 0.4902772 -0.41017445 0.05994583 0.05373333 0.01886667 -0.03486667 9.009613e-01 8.704957e-20 FALSE  
MSTRG.866.13 ENSG00000116922 HEK293_OSMI2_2hA HEK293_TMG_2hB C1orf109 protein_coding   32.96111 22.82212 45.38232 3.738659 1.165705 0.9913832 2.1141207 0.7688475 4.4702292 0.5095589 0.3286352 2.52415973 0.05663750 0.04023333 0.09896667 0.05873333 4.973300e-01 8.704957e-20 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116922 E001 0.3729606 0.0283713581 7.182767e-01 8.134307e-01 1 37681570 37681570 1 - 0.097 0.154 0.772
ENSG00000116922 E002 626.8559043 0.0021371158 1.083613e-13 3.063988e-12 1 37681571 37682735 1165 - 2.708 2.896 0.626
ENSG00000116922 E003 118.4815783 0.0046427780 9.962479e-01 1.000000e+00 1 37682736 37682789 54 - 2.067 2.095 0.093
ENSG00000116922 E004 89.0785633 0.0003796088 6.381870e-01 7.518813e-01 1 37682790 37682796 7 - 1.939 1.981 0.138
ENSG00000116922 E005 82.4419357 0.0003989476 5.316376e-01 6.640589e-01 1 37682797 37682797 1 - 1.924 1.923 -0.004
ENSG00000116922 E006 122.4556995 0.0012106885 6.555680e-01 7.654314e-01 1 37682798 37682812 15 - 2.089 2.095 0.022
ENSG00000116922 E007 397.9892050 0.0004523067 7.113617e-02 1.452260e-01 1 37682813 37683110 298 - 2.605 2.591 -0.048
ENSG00000116922 E008 169.1684220 0.0003367550 8.774470e-02 1.717125e-01 1 37683111 37683160 50 - 2.241 2.216 -0.085
ENSG00000116922 E009 2.1746543 0.0378222294 2.681473e-01 4.065766e-01 1 37683161 37683318 158 - 0.397 0.600 0.995
ENSG00000116922 E010 253.8372717 0.0001942668 1.835261e-06 1.439390e-05 1 37683319 37683437 119 - 2.439 2.353 -0.287
ENSG00000116922 E011 19.9090393 0.0077575747 5.882304e-02 1.246153e-01 1 37683438 37683441 4 - 1.374 1.222 -0.531
ENSG00000116922 E012 5.6048238 0.0076766816 2.096431e-01 3.381374e-01 1 37683442 37683476 35 - 0.874 0.720 -0.609
ENSG00000116922 E013 21.4092928 0.0385512285 9.471385e-01 9.707924e-01 1 37683477 37684192 716 - 1.336 1.345 0.031
ENSG00000116922 E014 137.2333144 0.0002811667 1.742409e-04 8.536626e-04 1 37686273 37686301 29 - 2.175 2.080 -0.318
ENSG00000116922 E015 214.9767701 0.0005897231 2.616796e-02 6.428967e-02 1 37686302 37686452 151 - 2.349 2.311 -0.125
ENSG00000116922 E016 7.9617568 0.0139326647 1.065623e-03 4.186190e-03 1 37689491 37689532 42 - 1.078 0.643 -1.690
ENSG00000116922 E017 5.6123005 0.0032214432 1.700741e-02 4.494980e-02 1 37689533 37689605 73 - 0.915 0.599 -1.280
ENSG00000116922 E018 105.2856192 0.0012122786 6.333755e-01 7.480975e-01 1 37689606 37689645 40 - 2.026 2.030 0.015
ENSG00000116922 E019 78.7385658 0.0004793283 8.999234e-01 9.401502e-01 1 37689646 37689657 12 - 1.895 1.912 0.057
ENSG00000116922 E020 147.5017750 0.0002437502 7.928067e-01 8.675150e-01 1 37689658 37689767 110 - 2.166 2.181 0.050
ENSG00000116922 E021 133.4992401 0.0002457348 6.696192e-01 7.763834e-01 1 37689768 37689883 116 - 2.113 2.149 0.121
ENSG00000116922 E022 20.9392864 0.0009312768 3.594644e-01 5.037911e-01 1 37689884 37689886 3 - 1.360 1.313 -0.167
ENSG00000116922 E023 71.0668737 0.0071095478 3.511461e-02 8.186308e-02 1 37690002 37690215 214 - 1.897 1.781 -0.393
ENSG00000116922 E024 120.5521283 0.0002985534 3.694962e-01 5.139119e-01 1 37690216 37690333 118 - 2.086 2.079 -0.024
ENSG00000116922 E025 125.0849355 0.0004146738 8.018465e-01 8.737442e-01 1 37690334 37690434 101 - 2.093 2.107 0.047
ENSG00000116922 E026 62.3679293 0.0003766992 4.537358e-01 5.944630e-01 1 37690435 37690438 4 - 1.805 1.793 -0.038
ENSG00000116922 E027 58.0895321 0.0005523219 2.321149e-01 3.649462e-01 1 37690439 37690529 91 - 1.784 1.750 -0.116
ENSG00000116922 E028 10.3435662 0.0039592261 4.898791e-01 6.272530e-01 1 37691048 37691458 411 - 1.069 1.015 -0.197
ENSG00000116922 E029 11.7860434 0.0014786358 6.942497e-01 7.951220e-01 1 37691459 37691581 123 - 1.113 1.096 -0.061
ENSG00000116922 E030 2.1002321 0.1011643950 8.334834e-01 8.956935e-01 1 37692026 37692029 4 - 0.511 0.489 -0.105
ENSG00000116922 E031 29.5883176 0.0042796976 4.892142e-01 6.266879e-01 1 37692030 37692188 159 - 1.497 1.468 -0.100
ENSG00000116922 E032 10.9448320 0.0016097165 9.534640e-01 9.748656e-01 1 37692189 37692305 117 - 1.069 1.096 0.097