ENSG00000116885

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000235532 ENSG00000116885 HEK293_OSMI2_2hA HEK293_TMG_2hB OSCP1 protein_coding protein_coding 10.26164 13.00735 9.491269 0.95992 0.8692727 -0.4542435 4.9025108 4.927962 3.8645645 1.1693205 0.47839724 -0.3498816 0.4922667 0.36960000 0.4221667 0.05256667 0.87362145 0.01503271 FALSE TRUE
ENST00000354267 ENSG00000116885 HEK293_OSMI2_2hA HEK293_TMG_2hB OSCP1 protein_coding protein_coding 10.26164 13.00735 9.491269 0.95992 0.8692727 -0.4542435 3.2124843 5.662917 3.3733007 0.4780828 0.28063695 -0.7456594 0.2988542 0.44543333 0.3559667 -0.08946667 0.59585916 0.01503271 FALSE TRUE
MSTRG.854.5 ENSG00000116885 HEK293_OSMI2_2hA HEK293_TMG_2hB OSCP1 protein_coding   10.26164 13.00735 9.491269 0.95992 0.8692727 -0.4542435 0.4322842 1.086748 0.2140764 0.2418241 0.05351649 -2.2911700 0.0395750 0.08446667 0.0221000 -0.06236667 0.01503271 0.01503271 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116885 E001 2.9421194 0.0056591087 0.229851955 0.36228130 1 36415827 36416095 269 - 0.688 0.507 -0.810
ENSG00000116885 E002 1.9865065 0.0252725762 0.343487867 0.48752394 1 36417906 36417909 4 - 0.555 0.394 -0.809
ENSG00000116885 E003 1.8048021 0.0094670641 0.216102543 0.34571411 1 36417910 36417910 1 - 0.555 0.348 -1.073
ENSG00000116885 E004 4.4940779 0.0085742568 0.704587911 0.80309774 1 36417911 36417942 32 - 0.759 0.713 -0.186
ENSG00000116885 E005 20.9402696 0.0268477960 0.372133300 0.51659366 1 36417943 36418059 117 - 1.240 1.357 0.410
ENSG00000116885 E006 47.0643837 0.0131638123 0.351814766 0.49602188 1 36418060 36418255 196 - 1.605 1.682 0.263
ENSG00000116885 E007 31.6720110 0.0090817829 0.486146189 0.62395540 1 36418991 36419054 64 - 1.450 1.511 0.210
ENSG00000116885 E008 1.0611596 0.0272163401 0.008326061 0.02460760 1 36419055 36419293 239 - 0.554 0.095 -3.394
ENSG00000116885 E009 0.7331366 0.0173302333 0.046463250 0.10287294 1 36420333 36420475 143 - 0.435 0.095 -2.812
ENSG00000116885 E010 51.7770789 0.0006436415 0.619593191 0.73695772 1 36420476 36420615 140 - 1.681 1.714 0.112
ENSG00000116885 E011 1.7274844 0.0091807850 0.214851036 0.34427158 1 36422002 36422149 148 - 0.555 0.348 -1.075
ENSG00000116885 E012 41.3900599 0.0155695867 0.870882082 0.92099430 1 36422150 36422219 70 - 1.609 1.606 -0.009
ENSG00000116885 E013 31.2938915 0.0099849439 0.682865123 0.78621126 1 36422768 36422785 18 - 1.462 1.498 0.121
ENSG00000116885 E014 46.8686477 0.0017363491 0.364423120 0.50879474 1 36422786 36422896 111 - 1.689 1.649 -0.135
ENSG00000116885 E015 42.7816536 0.0028628554 0.040728950 0.09237483 1 36423363 36423466 104 - 1.693 1.584 -0.368
ENSG00000116885 E016 0.5922303 0.0179955954 0.115513017 0.21358600 1 36423467 36423471 5 - 0.360 0.095 -2.397
ENSG00000116885 E017 22.1069909 0.0382613645 0.389924844 0.53396721 1 36428299 36428475 177 - 1.261 1.364 0.360
ENSG00000116885 E018 58.3509706 0.0004097990 0.680979245 0.78480555 1 36431802 36431860 59 - 1.732 1.759 0.091
ENSG00000116885 E019 43.9335458 0.0007178056 0.406366652 0.55002603 1 36431861 36431882 22 - 1.657 1.621 -0.124
ENSG00000116885 E020 86.9658342 0.0004946434 0.568602496 0.69523711 1 36432422 36432568 147 - 1.927 1.913 -0.049
ENSG00000116885 E021 47.9488846 0.0006372548 0.815658818 0.88332304 1 36432569 36432589 21 - 1.665 1.660 -0.017
ENSG00000116885 E022 91.1402004 0.0033291100 0.684819390 0.78771112 1 36438756 36438910 155 - 1.923 1.944 0.069
ENSG00000116885 E023 0.1817044 0.0400302138 0.801404727   1 36438911 36439000 90 - 0.000 0.095 8.467
ENSG00000116885 E024 0.0000000       1 36440819 36440975 157 -      
ENSG00000116885 E025 2.1660328 0.0075476722 0.701957122 0.80089417 1 36444004 36444033 30 - 0.435 0.507 0.359
ENSG00000116885 E026 0.6299079 0.0275429467 0.118650519 0.21801305 1 36447813 36447887 75 - 0.360 0.095 -2.395
ENSG00000116885 E027 69.1113994 0.0145827576 0.478873783 0.61729801 1 36450258 36450451 194 - 1.782 1.832 0.170