ENSG00000116874

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000235521 ENSG00000116874 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2 protein_coding protein_coding 13.4683 11.75348 16.90532 0.4191656 0.1675382 0.5240155 8.4744037 8.7785751 10.574098 0.2340665 0.3132059 0.2681972 0.64327500 0.7473333 0.62530000 -0.122033333 0.0009545292 0.0009545292 FALSE TRUE
ENST00000369426 ENSG00000116874 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2 protein_coding protein_coding 13.4683 11.75348 16.90532 0.4191656 0.1675382 0.5240155 0.9920142 0.8148078 1.073671 0.1999555 0.1048998 0.3937969 0.07240000 0.0686000 0.06346667 -0.005133333 0.9617219219 0.0009545292 FALSE TRUE
ENST00000495746 ENSG00000116874 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2 protein_coding processed_transcript 13.4683 11.75348 16.90532 0.4191656 0.1675382 0.5240155 1.5412804 0.6430190 1.740435 0.3215245 0.2806004 1.4225165 0.09921667 0.0530000 0.10313333 0.050133333 0.3408078502 0.0009545292 FALSE TRUE
MSTRG.1911.4 ENSG00000116874 HEK293_OSMI2_2hA HEK293_TMG_2hB WARS2 protein_coding   13.4683 11.75348 16.90532 0.4191656 0.1675382 0.5240155 2.0480696 1.2154591 2.747121 0.1855751 0.1439503 1.1698402 0.15331667 0.1047333 0.16236667 0.057633333 0.1961807321 0.0009545292 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116874 E001 2.2745615 0.1723227123 9.809719e-01 9.921161e-01 1 119026809 119026957 149 - 0.528 0.533 0.022
ENSG00000116874 E002 5.6496822 0.0651051293 6.277305e-01 7.434788e-01 1 119031216 119031233 18 - 0.782 0.866 0.327
ENSG00000116874 E003 498.9105612 0.0008653192 7.432978e-06 5.085246e-05 1 119031234 119032973 1740 - 2.659 2.738 0.265
ENSG00000116874 E004 176.2466138 0.0002332896 4.205917e-04 1.853364e-03 1 119032974 119033296 323 - 2.196 2.295 0.330
ENSG00000116874 E005 96.8076737 0.0010800656 5.001035e-01 6.363681e-01 1 119033297 119033359 63 - 1.995 1.978 -0.058
ENSG00000116874 E006 5.7185559 0.0030118094 9.696589e-01 9.850258e-01 1 119033360 119033388 29 - 0.823 0.826 0.010
ENSG00000116874 E007 82.3990038 0.0003776010 8.676967e-01 9.188934e-01 1 119034095 119034128 34 - 1.918 1.920 0.006
ENSG00000116874 E008 108.7004934 0.0002798560 4.141192e-01 5.575255e-01 1 119034129 119034213 85 - 2.048 2.030 -0.062
ENSG00000116874 E009 102.9384961 0.0003218896 8.831134e-03 2.585894e-02 1 119042264 119042349 86 - 2.054 1.973 -0.273
ENSG00000116874 E010 98.3324353 0.0002781835 1.467616e-02 3.976140e-02 1 119045582 119045662 81 - 2.035 1.959 -0.256
ENSG00000116874 E011 112.7588725 0.0002856261 2.237432e-02 5.645654e-02 1 119076350 119076520 171 - 2.089 2.024 -0.219
ENSG00000116874 E012 75.0872566 0.0004157451 3.294289e-04 1.498558e-03 1 119076521 119076607 87 - 1.947 1.811 -0.459
ENSG00000116874 E013 0.0000000       1 119082340 119082541 202 -      
ENSG00000116874 E014 0.8513531 0.0187565594 7.924334e-01 8.672958e-01 1 119139648 119140267 620 - 0.277 0.234 -0.326
ENSG00000116874 E015 1.9124241 0.1222260559 7.887424e-01 8.647423e-01 1 119140268 119140458 191 - 0.489 0.444 -0.230
ENSG00000116874 E016 52.0037600 0.0004897638 2.332938e-04 1.105362e-03 1 119140555 119140656 102 - 1.801 1.630 -0.579