ENSG00000116871

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373148 ENSG00000116871 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D1 protein_coding processed_transcript 57.48271 99.91559 37.79437 2.592662 1.258975 -1.402301 17.423990 40.707798 5.6302361 3.341830 1.4662342 -2.8518321 0.26528333 0.40810000 0.1468667 -0.261233333 0.0008599133 1.340457e-05 FALSE TRUE
ENST00000373150 ENSG00000116871 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D1 protein_coding protein_coding 57.48271 99.91559 37.79437 2.592662 1.258975 -1.402301 3.180679 7.307279 0.2977305 1.078634 0.2977305 -4.5715677 0.05328333 0.07366667 0.0081000 -0.065566667 0.0543924019 1.340457e-05 FALSE TRUE
ENST00000474796 ENSG00000116871 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D1 protein_coding protein_coding 57.48271 99.91559 37.79437 2.592662 1.258975 -1.402301 21.515743 32.077539 17.8776000 5.015365 1.2098147 -0.8430533 0.38159583 0.31950000 0.4757000 0.156200000 0.1686727328 1.340457e-05 FALSE TRUE
MSTRG.842.7 ENSG00000116871 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D1 protein_coding   57.48271 99.91559 37.79437 2.592662 1.258975 -1.402301 7.576663 13.466664 5.1658371 1.315807 0.3185697 -1.3805993 0.12599167 0.13476667 0.1365333 0.001766667 0.9785692216 1.340457e-05 FALSE TRUE
MSTRG.842.8 ENSG00000116871 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D1 protein_coding   57.48271 99.91559 37.79437 2.592662 1.258975 -1.402301 2.348064 1.906459 4.2261726 0.979825 0.3230162 1.1443185 0.04812083 0.01870000 0.1125000 0.093800000 0.2805684474 1.340457e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116871 E001 0.6234634 0.0196243538 9.544579e-01 9.754601e-01 1 36155579 36155733 155 + 0.187 0.202 0.138
ENSG00000116871 E002 0.1482932 0.0419365076 1.000000e+00   1 36155783 36155950 168 + 0.000 0.078 10.041
ENSG00000116871 E003 0.1482932 0.0419365076 1.000000e+00   1 36155951 36155964 14 + 0.000 0.078 10.041
ENSG00000116871 E004 0.4448795 0.5838767540 6.630417e-01 7.712032e-01 1 36155965 36156057 93 + 0.000 0.192 10.413
ENSG00000116871 E005 4.2843339 0.0118441368 2.188499e-01 3.490319e-01 1 36156058 36156153 96 + 0.804 0.618 -0.768
ENSG00000116871 E006 4.4618736 0.0035598570 5.495926e-02 1.179216e-01 1 36156154 36156159 6 + 0.872 0.598 -1.122
ENSG00000116871 E007 21.9521343 0.0258840773 8.302036e-03 2.454962e-02 1 36156160 36156174 15 + 1.477 1.202 -0.956
ENSG00000116871 E008 61.9449124 0.0240687586 4.633943e-05 2.632186e-04 1 36156175 36156197 23 + 1.960 1.613 -1.171
ENSG00000116871 E009 66.1747433 0.0258020100 9.140188e-05 4.815432e-04 1 36156198 36156201 4 + 1.985 1.645 -1.147
ENSG00000116871 E010 196.7838481 0.0173315495 2.997079e-05 1.783885e-04 1 36156202 36156463 262 + 2.415 2.140 -0.919
ENSG00000116871 E011 0.2955422 0.0297044138 4.670543e-01   1 36157215 36157290 76 + 0.187 0.078 -1.446
ENSG00000116871 E012 598.0501824 0.0013970625 3.937082e-11 7.435633e-10 1 36170971 36171315 345 + 2.814 2.662 -0.505
ENSG00000116871 E013 386.3417917 0.0012968349 2.649071e-05 1.596496e-04 1 36171513 36171581 69 + 2.592 2.484 -0.361
ENSG00000116871 E014 3.9201982 0.1070571377 7.233772e-03 2.183165e-02 1 36171582 36171823 242 + 0.957 0.446 -2.165
ENSG00000116871 E015 6.2535419 0.0034876613 4.002696e-05 2.306893e-04 1 36171968 36172463 496 + 1.125 0.619 -1.968
ENSG00000116871 E016 584.5122827 0.0005201456 1.785267e-01 2.993066e-01 1 36172464 36172627 164 + 2.711 2.685 -0.088
ENSG00000116871 E017 462.5828835 0.0001703725 9.758029e-01 9.889208e-01 1 36173364 36173478 115 + 2.589 2.589 -0.003
ENSG00000116871 E018 1.1125392 0.3963347821 3.242334e-01 4.676056e-01 1 36173479 36173479 1 + 0.417 0.212 -1.355
ENSG00000116871 E019 265.2142365 0.0001807867 3.790827e-02 8.717659e-02 1 36174898 36175008 111 + 2.306 2.358 0.175
ENSG00000116871 E020 315.7353672 0.0009640967 5.756896e-02 1.224501e-01 1 36176199 36176321 123 + 2.462 2.411 -0.169
ENSG00000116871 E021 149.7103621 0.0081079322 7.319591e-05 3.955485e-04 1 36176322 36176417 96 + 2.249 2.044 -0.686
ENSG00000116871 E022 179.4182552 0.0080811520 3.673554e-08 4.064617e-07 1 36176418 36176581 164 + 2.376 2.098 -0.927
ENSG00000116871 E023 114.4762576 0.0037347008 1.392831e-06 1.120838e-05 1 36176697 36176716 20 + 2.144 1.923 -0.741
ENSG00000116871 E024 282.2346777 0.0033393863 2.324940e-04 1.102014e-03 1 36176717 36176805 89 + 2.475 2.343 -0.442
ENSG00000116871 E025 269.6126691 0.0017811858 9.834627e-03 2.835830e-02 1 36176806 36176842 37 + 2.419 2.337 -0.271
ENSG00000116871 E026 2.8096322 0.0056627225 8.159149e-02 1.620428e-01 1 36177469 36177574 106 + 0.724 0.443 -1.274
ENSG00000116871 E027 575.8054233 0.0001494749 2.260291e-02 5.692610e-02 1 36177873 36178201 329 + 2.716 2.675 -0.135
ENSG00000116871 E028 3.7986799 0.0043387732 6.193076e-01 7.367573e-01 1 36178411 36178418 8 + 0.677 0.598 -0.344
ENSG00000116871 E029 96.3361006 0.0003109715 1.798145e-02 4.709236e-02 1 36178419 36178445 27 + 1.833 1.934 0.339
ENSG00000116871 E030 141.6687826 0.0002518094 6.194699e-02 1.298970e-01 1 36178446 36178470 25 + 2.028 2.093 0.216
ENSG00000116871 E031 385.5161202 0.0027196417 1.834021e-01 3.054771e-01 1 36178471 36178596 126 + 2.477 2.522 0.151
ENSG00000116871 E032 2.8753181 0.0055641166 3.424378e-02 8.022484e-02 1 36178597 36178684 88 + 0.187 0.598 2.463
ENSG00000116871 E033 584.7747683 0.0002643294 2.001910e-01 3.264845e-01 1 36178685 36178823 139 + 2.673 2.695 0.075
ENSG00000116871 E034 2.4579043 0.3148597883 1.684322e-01 2.861394e-01 1 36178824 36178920 97 + 0.769 0.364 -1.889
ENSG00000116871 E035 591.9471600 0.0001166955 7.266387e-04 2.994681e-03 1 36178921 36179020 100 + 2.652 2.709 0.191
ENSG00000116871 E036 335.1718812 0.0001427436 1.176952e-03 4.563166e-03 1 36179021 36179025 5 + 2.391 2.465 0.246
ENSG00000116871 E037 2.8409514 0.0317530511 8.712599e-01 9.212053e-01 1 36179026 36179261 236 + 0.498 0.529 0.148
ENSG00000116871 E038 556.4695966 0.0004456579 4.478820e-05 2.553105e-04 1 36179262 36179315 54 + 2.607 2.689 0.272
ENSG00000116871 E039 4.9545619 0.0805862847 1.181619e-01 2.173026e-01 1 36179316 36179511 196 + 0.929 0.634 -1.179
ENSG00000116871 E040 50.1127766 0.0016947708 5.610142e-02 1.198805e-01 1 36179512 36179514 3 + 1.542 1.659 0.400
ENSG00000116871 E041 572.6713342 0.0013666849 5.130120e-04 2.208380e-03 1 36179515 36179557 43 + 2.617 2.703 0.289
ENSG00000116871 E042 717.3601819 0.0017867828 2.147558e-03 7.682765e-03 1 36179666 36179756 91 + 2.721 2.800 0.262
ENSG00000116871 E043 1086.8831335 0.0020956185 6.695489e-03 2.043433e-02 1 36179874 36180067 194 + 2.909 2.978 0.228
ENSG00000116871 E044 1528.5673011 0.0019246712 1.173600e-09 1.716608e-08 1 36180248 36180849 602 + 3.003 3.139 0.452